The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Mergepta     2-[2- (diaminomethylideneamino) ethylsulfany...

Synonyms: Mergetpa, AG-L-65449, CTK8D5675, AR-1E5742, LS-177336, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Mergetpa

 

High impact information on Mergetpa

  • The nasal carboxypeptidase was activated 475% by 0.1 mM CoCl2 and was inhibited by the carboxypeptidase N inhibitor, MERGETPA (D-L-mercaptomethyl-3-guanidino-ethylthiopropanoic acid) (IC50 = 10 microM) [2].
  • The carboxypeptidase N inhibitor MERGETPA (D-L-mercaptoethanol-3-guanidino-ethylthiopropanoic acid) inhibited the plasma membrane bound carboxypeptidase with an I50 of 0.3 microM [3].
  • 3) The elimination of C3a plus C3adesArg immunoreactivity during a single liver passage was around 67%, irrespective of the perfusion direction and the presence of the carboxypeptidase inhibitor MERGETPA; however, less C3adesArg and more intact C3a appeared in the perfusate in the presence of MERGETPA in orthograde and retrogade perfusions [4].
  • In rat duodenum, an almost complete blockade of kininase activity was achieved when bacitracin and mergetpa were used together with enalaprilat [5].

References

  1. Inhibition of carboxypeptidase U (TAFIa) activity improves rt-PA induced thrombolysis in a dog model of coronary artery thrombosis. Björkman, J.A., Abrahamsson, T.I., Nerme, V.K., Mattsson, C.J. Thromb. Res. (2005) [Pubmed]
  2. Kinin metabolism in human nasal secretions during experimentally induced allergic rhinitis. Proud, D., Baumgarten, C.R., Naclerio, R.M., Ward, P.E. J. Immunol. (1987) [Pubmed]
  3. Kinin and enkephalin conversion by an endothelial, plasma membrane carboxypeptidase. Palmieri, F.E., Bausback, H.H., Churchill, L., Ward, P.E. Biochem. Pharmacol. (1986) [Pubmed]
  4. Differential effects of human anaphylatoxin C3a on glucose output and flow in rat liver during orthograde and retrograde perfusion: the periportal scavenger cell hypothesis. Püschel, G.P., Oppermann, M., Neuschäfer-Rube, F., Götze, O., Jungermann, K. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  5. Potentiation of bradykinin effects and inhibition of kininase activity in isolated smooth muscle. Schaffel, R., Rodrigues, M.S., Assreuy, J. Can. J. Physiol. Pharmacol. (1991) [Pubmed]
 
WikiGenes - Universities