Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CL-42A 2-[5-(3,5- dichlorophenyl)carbonyl-2...

Synonyms: KST-1A0244, AC1L2RUM, AC1Q3QDP, CTK8E0631, AR-1A9112, ...

Tornhamre, S. et al., Pruzanski, W. et al.

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High impact information on CL-42A

The effect of sulfasalazine and CL 42A was evident regardless of whether the cells were stimulated with IL-1beta/TNF-alpha, lipopolysaccharide/forskolin, or dibutyryl-cAMP [1].
Sulfasalazine and CL 42A markedly inhibited extracellular release of sPLA2 [1].
However, while CL 42A inhibited cyclooxygenase, the inhibitory effect of sulfasalazine was exerted mainly on thromboxane synthase [2].
Furthermore, CL 42A had no inhibitory effect on the production of 15-hydroxyeicosatetraenoic acid after incubation of human leukocytes with ionophore A23187 in the presence of exogenous arachidonic acid [2].

Associations of CL-42A with other chemical compounds

Sulfasalazine and CL 42A did not alter the level of sPLA2 mRNA [1].

References

Inhibition of extracellular release of proinflammatory secretory phospholipase A2 (sPLA2) by sulfasalazine: a novel mechanism of anti-inflammatory activity. Pruzanski, W., Stefanski, E., Vadas, P., Ramamurthy, N.S. Biochem. Pharmacol. (1997) [Pubmed]
Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products. Tornhamre, S., Edenius, C., Smedegård, G., Sjöquist, B., Lindgren, J.A. Eur. J. Pharmacol. (1989) [Pubmed]

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