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Chemical Compound Review

Agrocinopine     [(2R,3S,4S,5S)-4-hydroxy- 2,5...

Synonyms: Agrocinopine A, KST-1A8374, AR-1A3000, AC1L2S6H, AC1Q6A86, ...
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Disease relevance of Agrocinopine


High impact information on Agrocinopine

  • We have identified the gene responsible for synthesis in transformed cells of the phosphorylated sugar, agrocinopine, and at least three additional genes controlling the morphology of plant tumors [2].
  • We have cloned and sequenced a gene from the Ti plasmid pTiC58, whose product mediates the opine-dependent regulation of conjugal transfer and catabolism of the conjugal opines, agrocinopines A and B. The gene, accR, is closely linked to the agrocinopine catabolic locus [3].
  • Co-evolution of the agrocinopine opines and the agrocinopine-mediated control of TraR, the quorum-sensing activator of the Ti plasmid conjugation system [4].
  • We conclude that the agrocinopine opines and the corresponding opine-meditated conjugal regulatory regions of pTiChry5 and pTiC58 share a common origin, but that the opine signals for the two Ti plasmids have evolved divergently through changes in the opine synthase enzymes [4].
  • Two o/c Ti plasmids that are closely related to pTiTm4, pTiHm1, and pTiAB3, have a mutated acs gene; whereas Hm1 can still take up agrocinopine A, AB3 cannot [5].

Associations of Agrocinopine with other chemical compounds


Gene context of Agrocinopine

  • While the spontaneous Trac mutant Ti plasmids were also derepressed for agrocinopine catabolism, those generated by Tn5 insertions remained inducible, indicating that this apparent cis-acting site is different from that affected in the spontaneous mutants [6].


  1. Genetic analysis of the agrocinopine catabolic region of Agrobacterium tumefaciens Ti plasmid pTiC58, which encodes genes required for opine and agrocin 84 transport. Hayman, G.T., Beck von Bodman, S., Kim, H., Jiang, P., Farrand, S.K. J. Bacteriol. (1993) [Pubmed]
  2. Genetic analysis of T-DNA transcripts in nopaline crown galls. Joos, H., Inzé, D., Caplan, A., Sormann, M., Van Montagu, M., Schell, J. Cell (1983) [Pubmed]
  3. Opine catabolism and conjugal transfer of the nopaline Ti plasmid pTiC58 are coordinately regulated by a single repressor. Beck von Bodman, S., Hayman, G.T., Farrand, S.K. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. Co-evolution of the agrocinopine opines and the agrocinopine-mediated control of TraR, the quorum-sensing activator of the Ti plasmid conjugation system. Oger, P., Farrand, S.K. Mol. Microbiol. (2001) [Pubmed]
  5. Functional and mutated agrocinopine synthase genes on octopine T-DNAs. Paulus, F., Otten, L. Mol. Plant Microbe Interact. (1993) [Pubmed]
  6. Characterization of conjugal transfer functions of Agrobacterium tumefaciens Ti plasmid pTiC58. von Bodman, S.B., McCutchan, J.E., Farrand, S.K. J. Bacteriol. (1989) [Pubmed]
  7. Genetic analysis of agrocin 84 production and immunity in Agrobacterium spp. Ryder, M.H., Slota, J.E., Scarim, A., Farrand, S.K. J. Bacteriol. (1987) [Pubmed]
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