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Chemical Compound Review

Nopaline     (2R)-2-[[(1S)-1-carboxy-4...

Synonyms: Isonopaline, D-Nopaline, AG-J-20238, CHEBI:17249, CTK7D2127, ...
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Disease relevance of D-Nopaline


High impact information on D-Nopaline

  • We have determined which sequences at the right border of the T-DNA region of the nopaline C58 Ti plasmid are required for transfer and/or integration of the T-DNA into the plant cell genome [1].
  • To study the function of the genes of the T-DNA of the nopaline Ti plasmid, pTiC58, a collection of mutants was isolated so that T-DNA genes are inactivated either separately or in various combinations [6].
  • Size, location and polarity of T-DNA-encoded transcripts in nopaline crown gall tumors; common transcripts in octopine and nopaline tumors [2].
  • Transgenic N. glauca plants expressing bacterial virulence gene virF are converted into hosts for nopaline strains of A. tumefaciens [7].
  • To analyze relationships between RNA signals, DNA methylation and chromatin modifications, we performed a genetic screen to recover Arabidopsis mutants defective in RNA-directed transcriptional silencing and methylation of a nopaline synthase promoter-neomycinphosphotransferase II (NOSpro- NPTII) target gene [8].

Chemical compound and disease context of D-Nopaline


Biological context of D-Nopaline


Anatomical context of D-Nopaline

  • No complementation resulted when a nopaline virD2 clone containing a region similar to eukaryotic nuclear envelope transport sequences was deleted from the 3' end [18].

Associations of D-Nopaline with other chemical compounds


Gene context of D-Nopaline


Analytical, diagnostic and therapeutic context of D-Nopaline


  1. Right 25 bp terminus sequence of the nopaline T-DNA is essential for and determines direction of DNA transfer from agrobacterium to the plant genome. Wang, K., Herrera-Estrella, L., Van Montagu, M., Zambryski, P. Cell (1984) [Pubmed]
  2. Size, location and polarity of T-DNA-encoded transcripts in nopaline crown gall tumors; common transcripts in octopine and nopaline tumors. Willmitzer, L., Dhaese, P., Schreier, P.H., Schmalenbach, W., Van Montagu, M., Schell, J. Cell (1983) [Pubmed]
  3. In vitro DNA methylation inhibits gene expression in transgenic tobacco. Weber, H., Ziechmann, C., Graessmann, A. EMBO J. (1990) [Pubmed]
  4. Intron insertion facilitates amplification of cloned virus cDNA in Escherichia coli while biological activity is reestablished after transcription in vivo. Johansen, I.E. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. A cDNA clone of tomato mosaic virus is infectious in plants. Weber, H., Haeckel, P., Pfitzner, A.J. J. Virol. (1992) [Pubmed]
  6. Genetic analysis of T-DNA transcripts in nopaline crown galls. Joos, H., Inzé, D., Caplan, A., Sormann, M., Van Montagu, M., Schell, J. Cell (1983) [Pubmed]
  7. Transgenic N. glauca plants expressing bacterial virulence gene virF are converted into hosts for nopaline strains of A. tumefaciens. Regensburg-Tuïnk, A.J., Hooykaas, P.J. Nature (1993) [Pubmed]
  8. HDA6, a putative histone deacetylase needed to enhance DNA methylation induced by double-stranded RNA. Aufsatz, W., Mette, M.F., van der Winden, J., Matzke, M., Matzke, A.J. EMBO J. (2002) [Pubmed]
  9. Methylation of the T-DNA in Agrobacterium tumefaciens and in several crown gall tumors. Gelvin, S.B., Karcher, S.J., DiRita, V.J. Nucleic Acids Res. (1983) [Pubmed]
  10. Spontaneous mutation conferring the ability to catabolize mannopine in Agrobacterium tumefaciens. LaPointe, G., Nautiyal, C.S., Chilton, W.S., Farrand, S.K., Dion, P. J. Bacteriol. (1992) [Pubmed]
  11. Characterization and mapping of the agrocinopine-agrocin 84 locus on the nopaline Ti plasmid pTiC58. Hayman, G.T., Farrand, S.K. J. Bacteriol. (1988) [Pubmed]
  12. Expression of an Agrobacterium Ti plasmid gene involved in cytokinin biosynthesis is regulated by virulence loci and induced by plant phenolic compounds. John, M.C., Amasino, R.M. J. Bacteriol. (1988) [Pubmed]
  13. New class of limited-host-range Agrobacterium mega-tumor-inducing plasmids lacking homology to the transferred DNA of a wide-host-range, tumor-inducing plasmid. Unger, L., Ziegler, S.F., Huffman, G.A., Knauf, V.C., Peet, R., Moore, L.W., Gordon, M.P., Nester, E.W. J. Bacteriol. (1985) [Pubmed]
  14. Tumour genes in plants: T-DNA encoded cytokinin biosynthesis. Buchmann, I., Marner, F.J., Schröder, G., Waffenschmidt, S., Schröder, J. EMBO J. (1985) [Pubmed]
  15. Both positive and negative regulatory elements mediate expression of a photoregulated CAB gene from Nicotiana plumbaginifolia. Castresana, C., Garcia-Luque, I., Alonso, E., Malik, V.S., Cashmore, A.R. EMBO J. (1988) [Pubmed]
  16. The conserved part of the T-region in Ti-plasmids expresses four proteins in bacteria. Schröder, G., Klipp, W., Hillebrand, A., Ehring, R., Koncz, C., Schröder, J. EMBO J. (1983) [Pubmed]
  17. Absence of detectable transgenes in local landraces of maize in Oaxaca, Mexico (2003-2004). Ortiz-García, S., Ezcurra, E., Schoel, B., Acevedo, F., Soberón, J., Snow, A.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  18. VirD2 gene product from the nopaline plasmid pTiC58 has at least two activities required for virulence. Steck, T.R., Lin, T.S., Kado, C.I. Nucleic Acids Res. (1990) [Pubmed]
  19. Retention of tumor markers in F1 progeny plants from in vitro induced octopine and nopaline tumor tissues. Wullems, G.J., Molendijk, L., Ooms, G., Schilperoort, R.A. Cell (1981) [Pubmed]
  20. Sequence and mutational analysis of a tartrate utilization operon from Agrobacterium vitis. Crouzet, P., Otten, L. J. Bacteriol. (1995) [Pubmed]
  21. Factors influencing Agrobacterium-mediated transient expression of gusA in rice. Li, X.Q., Liu, C.N., Ritchie, S.W., Peng, J.Y., Gelvin, S.B., Hodges, T.K. Plant Mol. Biol. (1992) [Pubmed]
  22. Ornithine cyclodeaminase from octopine Ti plasmid Ach5: identification, DNA sequence, enzyme properties, and comparison with gene and enzyme from nopaline Ti plasmid C58. Schindler, U., Sans, N., Schröder, J. J. Bacteriol. (1989) [Pubmed]
  23. Plasmids in avirulent strains of Agrobacterium. Merlo, D.J., Nester, E.W. J. Bacteriol. (1977) [Pubmed]
  24. Nucleotide sequence of the virG locus of the Agrobacterium tumefaciens plasmid pTiC58. Powell, B.S., Powell, G.K., Morris, R.O., Rogowsky, P.M., Kado, C.I. Mol. Microbiol. (1987) [Pubmed]
  25. Characterization of the virA virulence gene of the nopaline plasmid, pTiC58, of Agrobacterium tumefaciens. Morel, P., Powell, B.S., Rogowsky, P.M., Kado, C.I. Mol. Microbiol. (1989) [Pubmed]
  26. Octopine and nopaline strains of Agrobacterium tumefaciens differ in virulence; molecular characterization of the virF locus. Melchers, L.S., Maroney, M.J., den Dulk-Ras, A., Thompson, D.V., van Vuuren, H.A., Schilperoort, R.A., Hooykaas, P.J. Plant Mol. Biol. (1990) [Pubmed]
  27. virG, an Agrobacterium tumefaciens transcriptional activator, initiates translation at a UUG codon and is a sequence-specific DNA-binding protein. Pazour, G.J., Das, A. J. Bacteriol. (1990) [Pubmed]
  28. The octopine-type Ti plasmid pTiA6 of Agrobacterium tumefaciens contains a gene homologous to the chromosomal virulence gene acvB. Kalogeraki, V.S., Winans, S.C. J. Bacteriol. (1995) [Pubmed]
  29. Cooperative interaction of Agrobacterium VirE2 protein with single-stranded DNA: implications for the T-DNA transfer process. Citovsky, V., Wong, M.L., Zambryski, P. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  30. A new opine derived from nopaline. Hall, L.M., Schrimsher, J.L., Taylor, K.B. J. Biol. Chem. (1983) [Pubmed]
  31. Relationship between Nif plasmids of fast-growing Rhizobium species and Ti plasmids of Agrobacterium tumefaciens. Prakash, R.K., Schilperoort, R.A. J. Bacteriol. (1982) [Pubmed]
  32. Cell-free cloning and biolistic inoculation of an infectious cDNA of potato virus Y. Fakhfakh, H., Vilaine, F., Makni, M., Robaglia, C. J. Gen. Virol. (1996) [Pubmed]
  33. Sequence analysis of an insertion element, IS1131, isolated from the nopaline-type Ti plasmid of Agrobacterium tumefaciens. Wabiko, H. Gene (1992) [Pubmed]
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