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Chemical Compound Review:

Lant-6 (2S)-2-[[(2S,3S)-2-[[(2S)-2- [[(2S)-1-[(2S)...

Synonyms: CTK8D8724, AR-1J3319, AC1L2U5O, 85213-84-9, 91284-28-5, ...

Reiner, A. et al., Eldred, W.D. et al., Veenman, C.L. et al., Eldred, W.D. et al., Carraway, R.E. et al., et al.

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High impact information on Neurotensin-related hexapeptide

This study investigated the presence of the neurotensin-related hexapeptide, LANT-6, in retinal ganglion cells and their central projections in the turtle Pseudemys scripta elegans [1].
Isolation, biological and chemical characterization, and synthesis of a neurotensin-related hexapeptide from chicken intestine [2].
The distribution of the neurotensin-related hexapeptide LANT6 within the basal ganglia and its projection targets was studied in turtles, pigeons, and hamsters by using immunohistochemical techniques, radioimmunoassay (RIA), gel chromatography, and high performance liquid chromatography (HPLC) [3].
LANT-6 is a hexapeptide (H-Lys-Asn-Pro-Tyr-Ile-Leu-OH) isolated from chicken small intestine, which resembles the COOH-terminal half of neurotensin, except for the amino acid substitutions Lys/Arg and Asn/Arg [4].
Phylogenetic conservatism in the presence of a neurotensin-related hexapeptide in neurons of globus pallidus [5].

Gene context of Neurotensin-related hexapeptide

Single-labeling experiments showed that many neurons in the dorsal thalamic zone are immunoreactive for neurotensin and the neurotensin-related hexapeptide, (Lys8,Asn9)NT(8-13) (LANT6) [6].

References

Ganglion cells in the turtle retina contain the neuropeptide LANT-6. Eldred, W.D., Isayama, T., Reiner, A., Carraway, R. J. Neurosci. (1988) [Pubmed]
Isolation, biological and chemical characterization, and synthesis of a neurotensin-related hexapeptide from chicken intestine. Carraway, R.E., Ferris, C.F. J. Biol. Chem. (1983) [Pubmed]
Immunohistochemical and biochemical studies on Lys8-Asn9-neurotensin8-13 (LANT6)-related peptides in the basal ganglia of pigeons, turtles, and hamsters. Reiner, A., Carraway, R.E. J. Comp. Neurol. (1987) [Pubmed]
Immunocytochemical localization of LANT-6-like immunoreactivity within neurons in the inner nuclear and ganglion cell layers in vertebrate retinas. Eldred, W.D., Li, H.B., Carraway, R.E., Dowling, J.E. Brain Res. (1987) [Pubmed]
Phylogenetic conservatism in the presence of a neurotensin-related hexapeptide in neurons of globus pallidus. Reiner, A., Carraway, R.E. Brain Res. (1985) [Pubmed]
Thalamostriatal projection neurons in birds utilize LANT6 and neurotensin: a light and electron microscopic double-labeling study. Veenman, C.L., Karle, E.J., Anderson, K.D., Reiner, A. J. Chem. Neuroanat. (1995) [Pubmed]

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