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Gene Review

NTS  -  neurotensin

Gallus gallus

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Disease relevance of NTS

  • These data demonstrate the presence in chicken liver of large amounts of high-affinity NT receptor(s) coupled to pertussis toxin-sensitive G-protein(s) [1].
  • Neurotensin (NT), given intravenously at 10-50 pmol/kg per min to anesthetized female chickens equipped with a bile duct fistula, dose-dependently elevated hepatic bile flow and bile acid output but only when the enterohepatic circulation was maintained by returning the bile to the intestinal lumen [2].

High impact information on NTS

  • Substance P (SP), neurotensin (NT), bombesin (BB), serotonin (5HT), and carbamylcholine (CCH) transiently increase electrogenic anion secretion in chinchilla and chicken ileum [3].
  • Loperamide (LP) inhibits the short-circuit current responses caused by SP, NT, and BB, but not those caused by CCH, 5HT, Ca ionophore, or cyclic nucleotides [3].
  • Hence pancreatic mesenchyme did not materially affect the proportions of these three cell types in experimental grafts, induced no specific pancreatic (insulin) cell type and allowed the differentiation of the characteristic proventricular endocrine cell types, neurotensin and bombesin/GRP cells [4].
  • Distribution of neurotensin-containing neurons in the central nervous system of the pigeon and the chicken [5].
  • Our observations suggest the presence of a very wide network of neurotensin-containing neurons in the avian brain and spinal cord, which is also the case in mammals [5].

Biological context of NTS

  • Membrane potential and current responses to neurotensin in the longitudinal muscle of the rectum of the fowl [6].
  • 5. The apparent Kd (approximately 91 pM) for this single class of binding sites was similar to Kds reported for the high-affinity components of NT binding to mammalian brain and intestinal membranes [1].
  • Neurotensin produced a contractile response in ileal muscle strips pretreated with apamin (50 nM) and in isolated chick rectums and both contractile effects were inhibited by SR 48692 with IC50 of 31.6+/-9.5 nM and Kh of 3.2+/-0.9 nM (n = 6) and with IC50 of 28.9+/-6.9 nM and Kb of 5.4+/-1.0 nM (n = 7), respectively [7].
  • Neurotensin decreases pepsin output and gastrointestinal motility in chickens [8].
  • The amino acid sequence of a smooth muscle-contracting peptide from chicken rectum. Identity to chicken neurotensin [9].

Anatomical context of NTS


Associations of NTS with chemical compounds


Other interactions of NTS


Analytical, diagnostic and therapeutic context of NTS


  1. Chicken liver contains a large quantity of a G-protein-linked neurotensin receptor. Mitra, S.P., Carraway, R.E. Peptides (1995) [Pubmed]
  2. Neurotensin elevates hepatic bile acid secretion in chickens by a mechanism requiring an intact enterohepatic circulation. Gui, X., Degolier, T.F., Duke, G.E., Carraway, R.E. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2000) [Pubmed]
  3. Secretagogue-induced changes in membrane calcium permeability in chicken and chinchilla ileal mucosa. Selective inhibition by loperamide. Chang, E.B., Brown, D.R., Wang, N.S., Field, M. J. Clin. Invest. (1986) [Pubmed]
  4. The effect of pancreatic mesenchyme on the differentiation of endocrine cells from gastric endoderm. Kramer, B., Andrew, A., Rawdon, B.B., Becker, P. Development (1987) [Pubmed]
  5. Distribution of neurotensin-containing neurons in the central nervous system of the pigeon and the chicken. Atoji, Y., Shibata, N., Yamamoto, Y., Suzuki, Y. J. Comp. Neurol. (1996) [Pubmed]
  6. Membrane potential and current responses to neurotensin in the longitudinal muscle of the rectum of the fowl. Komori, S., Matsuoka, T., Kwon, S.C., Takewaki, T., Ohashi, H. Br. J. Pharmacol. (1992) [Pubmed]
  7. Characterization of neurotensin receptors in intestinal smooth muscle using a nonpeptide antagonist. Unno, T., Komori, S., Ohashi, H. Eur. J. Pharmacol. (1999) [Pubmed]
  8. Neurotensin decreases pepsin output and gastrointestinal motility in chickens. Degolier, T.F., Duke, G.E., Carraway, R.E. Poult. Sci. (1997) [Pubmed]
  9. The amino acid sequence of a smooth muscle-contracting peptide from chicken rectum. Identity to chicken neurotensin. Iwabuchi, H., Komori, S., Ohashi, H., Kimura, S. Jpn. J. Pharmacol. (1987) [Pubmed]
  10. Distribution of vasoactive intestinal polypeptide-, substance P-, enkephalin and neurotensin-like immunoreactive nerves in the chicken gut during development. Saffrey, M.J., Polak, J.M., Burnstock, G. Neuroscience (1982) [Pubmed]
  11. The coexistence of three neuroactive substances in amacrine cells of the chicken retina. Wu, S.M., Lam, D.M. Brain Res. (1988) [Pubmed]
  12. An immunocytochemical survey of endocrine cells in the gastrointestinal tract of chicks at hatching. Rawdon, B.B., Andrew, A. Cell Tissue Res. (1981) [Pubmed]
  13. Alterations in retinal neurotransmitter receptors and neuropeptides of the chick by kainic acid and acrylamide. Ali, S.F., Hong, J.S., Bondy, S.C. Brain Res. (1983) [Pubmed]
  14. Quantitative studies of enkephalin's coexistence with gamma-aminobutyric acid, glycine and neurotensin in amacrine cells of the chicken retina. Watt, C.B., Li, T., Lam, D.M., Wu, S.M. Brain Res. (1988) [Pubmed]
  15. Ontogeny, distribution and amine/peptide colocalization of chromogranin A- and B-immunoreactive cells in the chicken gizzard and antrum. Salvi, E., Buffa, R., Renda, T.G. Anat. Embryol. (1995) [Pubmed]
  16. An immunohistochemical study of the ontogeny of the neuroendocrine system in the chicken oesophagus. Salvi, E., Vaccaro, R., Renda, T.G. Anat. Embryol. (1998) [Pubmed]
  17. Localization of vasoactive intestinal polypeptide and neurotensin immunoreactivities in the avian retina. Fukuda, M., Kuwayama, Y., Shiosaka, S., Inagaki, S., Ishimoto, I., Shimizu, Y., Takagi, H., Sakanaka, M., Takatsuki, K., Senba, E., Tohyama, M. Curr. Eye Res. (1981) [Pubmed]
  18. A common precursor to neurotensin and LANT6 and its differential processing in chicken tissues. Carraway, R.E., Mitra, S.P., Duke, G.E. Peptides (1993) [Pubmed]
  19. Development of the enkephalin-, neurotensin- and somatostatin-like (ENSLI) amacrine cells in the chicken retina. Yang, D.S., Boelen, M.K., Morgan, I.G. Brain Res. Dev. Brain Res. (1997) [Pubmed]
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