The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

Table of contents

About

Terms

 

Chemical Compound Review: 

Org-9935     6-(5,6- dimethoxybenzothiophen-2-yl)- 5...

Synonyms: CHEMBL2074862, SureCN4943014, AC1L2YKU, Org 9935, 129425-83-8
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Org 9935

  • This study evaluated the impact of meiosis arrest by PDE3 inhibitor, Org 9935, on developmental competence of geminal vesicle (GV)-stage oocytes from small antral follicles [1].
  • Making use of a selective PDE 3 inhibitor, Org 9935 (10 microM), oocytes retrieved from immature follicles were arrested in prophase I with a high efficiency for up to 72 h [2].
  • 4 PDE IV-selective (rolipram), PDE III-selective (Org 9935) and dual PDE III/IV (Org 30029) inhibitors were effective relaxants of human bronchial smooth muscle [3].
  • Infiltration of lymphocytes and macrophages was significantly inhibited by Org 9935 only (P<0.05 and P<0.01, respectively), whereas neutrophil influx was not significantly affected [4].
  • Although the shape of the concentration-inhibition curve for Org 30029 precluded estimation of an IC50 value, this drug was clearly much less potent than Org 9935 (IC50 about 50 nM) in inhibiting islet phosphodiesterase activity [5].

References

  1. Effect of phosphodiesterase type 3 inhibitor on developmental competence of immature mouse oocytes in vitro. Nogueira, D., Cortvrindt, R., De Matos, D.G., Vanhoutte, L., Smitz, J. Biol. Reprod. (2003) [Pubmed]
  2. Human oocytes reversibly arrested in prophase I by phosphodiesterase type 3 inhibitor in vitro. Nogueira, D., Albano, C., Adriaenssens, T., Cortvrindt, R., Bourgain, C., Devroey, P., Smitz, J. Biol. Reprod. (2003) [Pubmed]
  3. Human bronchial cyclic nucleotide phosphodiesterase isoenzymes: biochemical and pharmacological analysis using selective inhibitors. de Boer, J., Philpott, A.J., van Amsterdam, R.G., Shahid, M., Zaagsma, J., Nicholson, C.D. Br. J. Pharmacol. (1992) [Pubmed]
  4. Bronchodilatory and anti-inflammatory properties of inhaled selective phosphodiesterase inhibitors in a guinea pig model of allergic asthma. Santing, R.E., de Boer, J., Rohof, A., van der Zee, N.M., Zaagsma, J. Eur. J. Pharmacol. (2001) [Pubmed]
  5. The effect of selective phosphodiesterase inhibitors on plasma insulin concentrations and insulin secretion in vitro in the rat. El-Metwally, M., Shafiee-Nick, R., Pyne, N.J., Furman, B.L. Eur. J. Pharmacol. (1997) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities