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Chemical Compound Review

CHEBI:73271     3-amino-9-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: AC1L31O3, 148608-52-0, G*, 7-formamidino-7-deazaguanosine
 
 
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High impact information on Archaeosine

  • The RNA-binding PUA domain of archaeal tRNA-guanine transglycosylase is not required for archaeosine formation [1].
  • From homology searching of the Methanococcus jannaschii genome, a gene coding for an enzyme in the biosynthesis of archaeosine (tgt) was identified and cloned [2].
  • The C-terminal one-third of YebU contains a domain similar to that in pseudouridine synthases and archaeosine-specific transglycosylases (PUA-domain), which was not predicted by sequence alignments [3].
  • In archaebacteria, TGT is responsible for the introduction of archaeosine into the D-loop of the appropriate tRNAs [4].
  • Structure-based homology analysis with DALI revealed that the C domain of KD93 matches the PUA domain of some RNA modification enzymes, especially that of archaeosine tRNA-ribosyltransferase (ArcTGT), which suggests that its possible molecular function is related to RNA binding [5].
 

Analytical, diagnostic and therapeutic context of Archaeosine

References

  1. The RNA-binding PUA domain of archaeal tRNA-guanine transglycosylase is not required for archaeosine formation. Sabina, J., Söll, D. J. Biol. Chem. (2006) [Pubmed]
  2. Hypermodification of tRNA in Thermophilic archaea. Cloning, overexpression, and characterization of tRNA-guanine transglycosylase from Methanococcus jannaschii. Bai, Y., Fox, D.T., Lacy, J.A., Van Lanen, S.G., Iwata-Reuyl, D. J. Biol. Chem. (2000) [Pubmed]
  3. The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain. Hallberg, B.M., Ericsson, U.B., Johnson, K.A., Andersen, N.M., Douthwaite, S., Nordlund, P., Beuscher, A.E., Erlandsen, H. J. Mol. Biol. (2006) [Pubmed]
  4. tRNA-guanine transglycosylase from Escherichia coli: recognition of noncognate-cognate chimeric tRNA and discovery of a novel recognition site within the TpsiC arm of tRNA(Phe). Kung, F.L., Nonekowski, S., Garcia, G.A. RNA (2000) [Pubmed]
  5. Crystal structure of KD93, a novel protein expressed in human hematopoietic stem/progenitor cells. Liu, J.F., Wang, X.Q., Wang, Z.X., Chen, J.R., Jiang, T., An, X.M., Chang, W.R., Liang, D.C. J. Struct. Biol. (2004) [Pubmed]
  6. Crystallization and preliminary X-ray analysis of the archaeosine tRNA-guanine transglycosylase from Pyrococcus horikoshii. Ishitani, R., Nureki, O., Kijimoto, T., Watanabe, M., Kondo, H., Nameki, N., Okada, N., Nishimura, S., Yokoyama, S. Acta Crystallogr. D Biol. Crystallogr. (2001) [Pubmed]
 
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