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Chemical Compound Review

SureCN6806973     (13S,14R)-3,4-dihydroxy-13- methyl-12,14,15...

Synonyms: LS-64745, AR-1E9217, AC1L33BC, AC1Q6OA1, 4-Hydroxyequilenin
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Disease relevance of 4-Hydroxyequilenin


High impact information on 4-Hydroxyequilenin


Analytical, diagnostic and therapeutic context of 4-Hydroxyequilenin

  • In order to be able to analyze these adducts in in vivo samples a method based upon the coupling of miniaturized liquid chromatography (LC) to electrospray tandem mass spectrometry (ES-MS/MS) was developed for the analysis of the adducts formed with 4-hydroxyequilenin [6].


  1. A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines. Chen, Y., Liu, X., Pisha, E., Constantinou, A.I., Hua, Y., Shen, L., van Breemen, R.B., Elguindi, E.C., Blond, S.Y., Zhang, F., Bolton, J.L. Chem. Res. Toxicol. (2000) [Pubmed]
  2. Mutagenic events induced by 4-hydroxyequilin in supF shuttle vector plasmid propagated in human cells. Yasui, M., Matsui, S., Laxmi, Y.R., Suzuki, N., Kim, S.Y., Shibutani, S., Matsuda, T. Carcinogenesis (2003) [Pubmed]
  3. The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone. Zhang, F., Chen, Y., Pisha, E., Shen, L., Xiong, Y., van Breemen, R.B., Bolton, J.L. Chem. Res. Toxicol. (1999) [Pubmed]
  4. Response of human mammary epithelial cells to DNA damage induced by 4-hydroxyequilenin: Lack of p53-mediated G1 arrest. Cuendet, M., Bolton, J.L. Chem. Biol. Interact. (2006) [Pubmed]
  5. Characterization of two new variants of human catechol O-methyltransferase in vitro. Li, Y., Yang, X., van Breemen, R.B., Bolton, J.L. Cancer Lett. (2005) [Pubmed]
  6. Equilenin-2'-deoxynucleoside adducts: analysis with nano-liquid chromatography coupled to nano-electrospray tandem mass spectrometry. Embrechts, J., Lemière, F., Van Dongen, W., Esmans, E.L. Journal of mass spectrometry : JMS. (2001) [Pubmed]
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