Disease relevance of Edbpha

• Brucella abortus grown in low-iron medium or in the presence of iron chelators [ethylenediamine-di(o-hydroxyphenylacetic acid) and 2,2-dipyridyl] showed reduced cell yields and released a material positive in chemical and biological assays for catechols [1].
• Pseudomonas aeruginosa K437 lacks the ferripyoverdine receptor and, as a result, grows poorly on an iron-deficient minimal medium supplemented with ethylenediamine-di(o-hydroxyphenylacetic acid) (EDDHA) and pyroverdine [2].
• The concentration of ethylenediamine di(o-hydroxyphenylacetic acid) (EDDA) required to inhibit the growth of individual Citrobacter strains by depleting free iron ranged from 250 micrograms/ml to 100 micrograms/ml [3].
• The use of EDBPHA as a potential iron chelator in cases of hemochromatosis provided impetus for investigating its toxicology [4].

High impact information on Edbpha

• Mutants lacking both PMT1 and PMT6 are viable and show pmt1 mutant phenotypes and an additional sensitivity to the iron chelator ethylenediamine-di(o-hydroxyphenylacetic acid) [5].
• When grown under iron restricted-conditions in the presence of ethylenediamine di(o-hydroxyphenylacetic acid), hemoglobin, hematin and hemin were found to stimulate growth in both liquid and agar bioassays [6].
• In the absence of hemoglobin and hematocrit changes, i.v. EDBPHA reduced renal iron 40% and hepatic iron 15% to 25% without altering splenic iron [4].

References