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Gene Review:

PMT6 - dolichyl-phosphate-mannose-protein...

Saccharomyces cerevisiae S288c

Synonyms: Dolichyl-phosphate-mannose--protein mannosyltransferase 6, G7722, YGR199W

Timpel, C. et al., Shaw, B.D. et al.

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High impact information on PMT6

Mutants lacking both PMT1 and PMT6 are viable and show pmt1 mutant phenotypes and an additional sensitivity to the iron chelator ethylenediamine-di(o-hydroxyphenylacetic acid) [1].
Mutants lacking one or two PMT6 alleles grow normally and contain normal Pmt enzymatic activities in cell extracts but show phenotypes including a partial block of hyphal formation (dimorphism) and a supersensitivity to hygromycin B [1].
The lack of Pmt6p significantly reduces adherence to endothelial cells and overall virulence in a mouse model of systemic infection [1].
Morphogenesis, adhesive properties, and antifungal resistance depend on the Pmt6 protein mannosyltransferase in the fungal pathogen candida albicans [1].
Phylogenetic analysis indicates that PmtA is most closely related to the S. cerevisiae sub-family of PMTs containing Pmt2, Pmt3 and Pmt6 [2].

Regulatory relationships of PMT6

The results suggest that Pmt6p regulates a more narrow subclass of proteins in C. albicans than Pmt1p, including secreted proteins responsible for morphogenesis and antifungal sensitivities [1].

References

Morphogenesis, adhesive properties, and antifungal resistance depend on the Pmt6 protein mannosyltransferase in the fungal pathogen candida albicans. Timpel, C., Zink, S., Strahl-Bolsinger, S., Schröppel, K., Ernst, J. J. Bacteriol. (2000) [Pubmed]
Aspergillus nidulans polarity mutant swoA is complemented by protein O-mannosyltransferase pmtA. Shaw, B.D., Momany, M. Fungal Genet. Biol. (2002) [Pubmed]

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