Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Diaphene 3,5-dibromo-N-(4- bromophenyl)-2-hydroxy...

Synonyms: Trisanil, Trisanyl, Agramed, Tuasol, Tribromsalan, ...

Horio, T., Vohr, H.W. et al., De Vries, H. et al., Horio, T.

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Disease relevance of Vancide TBS

Photoallergic contact dermatitis developed in a patient who had used deodorant soaps containing tribromsalan [1].

High impact information on Vancide TBS

Allergic photocontact sensitization could be induced in guinea pigs with 3,3',4',5-tetrachlorosalicylanilide (TCSA), 3,4',5-tribromosalicylanilide (TBS), and bithionol using pretreatment with sodium lauryl sulfate (SLS) and long-wave ultraviolet (UVA) radiation [2].
We found an ultraviolet A (UVA) irradiation-dependent increase in the weights and cell counts of the auricular lymph nodes after application of 8-methoxypsoralen, tribromosalicylanilide, trichlorosalicylanilide, chlorpromazine and promethazine [3].

Chemical compound and disease context of Vancide TBS

In this study attention has been paid to the possible occurrence of a detoxifying action of glutathione on the photoreaction of 3,4',5-tribromosalicylanilide (tbsa), which is notorious for causing photoallergy [4].

References

Actinic reticuloid via persistent light reaction from photoallergic contact dermatitis. Horio, T. Archives of dermatology. (1982) [Pubmed]
The induction of photocontact sensitivity in guinea pigs without UVB radiation. Horio, T. J. Invest. Dermatol. (1976) [Pubmed]
Detection of photoreactivity demonstrated in a modified local lymph node assay in mice. Vohr, H.W., Homey, B., Schuppe, H.C., Kind, P. Photodermatology, photoimmunology & photomedicine. (1994) [Pubmed]
The influence of glutathione on the photoreaction of 3,4',5-tribromosalicylanilide alone and in the presence of serum albumin. De Vries, H., Beijersbergen van Henegouwen, G.M. Pharmaceutisch weekblad. Scientific edition. (1981) [Pubmed]

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