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Chemical Compound Review:

TCSA 3,5-dichloro-N-(3,4- dichlorophenyl)-2...

Synonyms: CHEMBL291338, SureCN168748, BS-200, Irgasan BS-200, HSDB 7730, ...

Wakabayashi, S. et al., Barratt, M.D. et al., Tokura, Y. et al., Tokura, Y. et al., Hamaide, F. et al., et al.

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Disease relevance of BS-200

Murine contact photosensitivity (CPS) to 3,3',4',5-tetrachlorosalicylanilide (TCSA) is a cutaneous delayed-type hypersensitivity reaction in which both positive and negative regulatory pathways exist [1].
Photosensitization to 3,3',4',5-tetrachlorosalicylanilide (TCSA) was significantly suppressed by the pretreatment of mice with L-SOD [2].
Several antibacterial halogenated salicylanilides, including 3,3',4',5-tetrachlorosalicylanilide (TCSA) and 3,4',5-tribromosalicylanilide (TBSA) are known to cause photoallergy [3].

High impact information on BS-200

Mechanism for 3,3',4',5-tetrachlorosalicylanilide-induced activation of sarcoplasmic reticulum ATPase [4].
Microsomes were enriched in the enzyme marker gamma-glutamyl transferase and contained an ATP-dependent proton pump, as evidenced by ATP-dependent, 3,3',4',5-tetrachlorosalicylanilide-reversible quenching of acridine orange fluorescence [5].
Growth in complex medium at pH 8.5 was prevented by a high concentration (50 microM) of carbonyl cyanide m-chlorophenyl-hydrazone (CCCP) or a low concentration (5 microM) of another protonophore, 3,3',4',5-tetrachlorosalicylanilide (TCS) [6].
This study was conducted to investigate in vivo evaluation of protectiveness by sunscreens in the UVA range using a mouse model of contact photoallergy (CPS) to 3,3',4',5-tetrachlorosalicylanilide (TCSA) [7].
In murine contact photosensitivity (CPS) to 3,3',4',5-tetrachlorosalicylanilide, we have reported that antigen-specific suppressor T cells and factor(s) (TsF) are induced by preexposure of the photosensitizing site to low doses of ultraviolet B [8].

Biological context of BS-200

Effects of 3,3',4',5-tetrachlorosalicylanilide (TCS), a lipophilic weak acid, on Ca2+ uptake and ATP hydrolysis by the sarcoplasmic reticulum calcium pump were characterized to obtain insight into the possible role of hydrophobic portions of the Ca2+-ATPase in the catalytic mechanism of the enzyme [4].

Associations of BS-200 with other chemical compounds

1. The interaction of the germicide 3,3',4',5-tetrachlorosalicylanilide (T4CS) with vesicles and dispersions of egg phosphatidylcholine has been studied by gel permeation chromatography, electron microscopy, electron spin resonance spin labelling and ion permeability measurements [9].

Analytical, diagnostic and therapeutic context of BS-200

We studied the genetic control of murine contact photosensitivity (CPS)1 to 3,3',4',5-tetrachlorosalicylanilide (TCSA) that was induced by subcutaneous injection of TCSA-photomodified epidermal cells (photoTCSA-EC) and spleen cells (photoTCSA-SC) [10].

References

Th2 suppressor cells are more susceptible to sphingosine than Th1 cells in murine contact photosensitivity. Tokura, Y., Wakita, H., Yagi, H., Nishimura, K., Furukawa, F., Takigawa, M. J. Invest. Dermatol. (1996) [Pubmed]
Mechanisms of contact photosensitivity in mice. VI. Oxygen intermediates are involved in contact photosensitization but not in ordinary contact sensitization. Miyachi, Y., Imamura, S., Niwa, Y., Tokura, Y., Takigawa, M. J. Invest. Dermatol. (1986) [Pubmed]
Spectroscopic studies of cutaneous photosensitizing agents--XIV. The spin trapping of free radicals formed during the photolysis of halogenated salicylanilide antibacterial agents. Chignell, C.F., Sik, R.H. Photochem. Photobiol. (1989) [Pubmed]
Mechanism for 3,3',4',5-tetrachlorosalicylanilide-induced activation of sarcoplasmic reticulum ATPase. Wakabayashi, S., Ogurusu, T., Shigekawa, M. J. Biol. Chem. (1988) [Pubmed]
Characterization of an electrogenic ATP and chloride-dependent proton translocating pump from rat renal medulla. Kaunitz, J.D., Gunther, R.D., Sachs, G. J. Biol. Chem. (1985) [Pubmed]
Proton circulation in Vibrio costicola. Hamaide, F., Kushner, D.J., Sprott, G.D. J. Bacteriol. (1985) [Pubmed]
Evaluation of ultraviolet-A protection by sunscreen agents using a mouse model of contact photoallergy. Tokura, Y., Yagi, H., Ihda, H., Takigawa, M. J. Dermatol. Sci. (1994) [Pubmed]
Ultraviolet-induced suppressor T cells and factor(s) in murine contact photosensitivity. II. Igh-V restriction of T-cell-suppressor factor. Tokura, Y., Takigawa, M., Satoh, T., Sugimoto, H., Yamada, M. Clin. Immunol. Immunopathol. (1989) [Pubmed]
The interaction of 3,3',4',5-tetrachlorosalicylanilide with phosphatidylcholine bilayers. Barratt, M.D., Weaver, A.C. Biochim. Biophys. Acta (1979) [Pubmed]
Genetic control of contact photosensitivity to tetrachlorosalicylanilide. II. Igh complex controls the sensitivity induced by photohapten-modified spleen cells but not epidermal cells. Tokura, Y., Satoh, T., Yamada, M., Takigawa, M. Cell. Immunol. (1991) [Pubmed]

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