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Chemical Compound Review:

Arlacel-20 [2-[(2R,3S,4R)-3,4- dihydroxyoxolan-2-yl]-2...

Synonyms: Glycomul L, Glycomul LC, Arlacel 20, Armotan ML, Montane 20, ...

López-Castellano, A. et al., Naskar, M.K. et al., Lin, S.Y. et al., Varshosaz, J. et al., Cater, B.R. et al.

Varshosaz, Pardakhty, Hajhashemi, Najafabadi, López-Castellano, Cortell-Ivars, López-Carballo, Herráez-Domínguez,

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Disease relevance of Arlacel-20

Short-term toxicity study of sorbitan monolaurate (Span 20) in rats [1].

High impact information on Arlacel-20

The Span 20 with the higher HLB value of 8.6 has been found to be highly suitable in synthesizing TEA-capped ZnS nanoparticles of smaller size and higher photophysical characteristics compared to that of the Span 80 of lower HLB value of 4 [2].
Addition of sorbitan laurate (Span 20) in the whey protein coating solution up to the critical micelle concentration (cmc) of 0.05% (w/w) significantly improved coating coverage to 88% of the peanut surface [3].
Recently we have proved that Span 20 has the same enhancer effect as Azone on in vitro percutaneous penetration of lipophilic compounds (logP(oct) from 1.34 to 2.33) [4].
Niosomes of sorbitan monoesters (Span 20, 40, 60, and 80) were prepared using the film hydration method without sonication [5].

Biological context of Arlacel-20

To quantify and compare the effect of Span 20 and Azone, the compressibility of enhancer-lipid model mixed monolayers was calculated, and expressed as a function of mole fraction of enhancer present on the films [4].

References

Short-term toxicity study of sorbitan monolaurate (Span 20) in rats. Cater, B.R., Butterworth, K.R., Gaunt, I.F., Hooson, J., Grasso, P., Gangolli, S.D. Food and cosmetics toxicology. (1978) [Pubmed]
Understanding the role of surfactants on the preparation of ZnS nanocrystals. Naskar, M.K., Patra, A., Chatterjee, M. Journal of colloid and interface science. (2006) [Pubmed]
Whey protein coating efficiency on surfactant-modified hydrophobic surfaces. Lin, S.Y., Krochta, J.M. J. Agric. Food Chem. (2005) [Pubmed]
The influence of Span20 on stratum corneum lipids in langmuir monolayers: comparison with Azone. López-Castellano, A., Cortell-Ivars, C., López-Carballo, G., Herráez-Domínguez, M. International journal of pharmaceutics. (2000) [Pubmed]
Development and physical characterization of sorbitan monoester niosomes for insulin oral delivery. Varshosaz, J., Pardakhty, A., Hajhashemi, V.I., Najafabadi, A.R. Drug delivery. (2003) [Pubmed]

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