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Chemical Compound Review

SureCN4506     [2-(3,4-dihydroxyoxolan-2- yl)-2-hydroxy...

Synonyms: Span 80, NSC-406239, AC1NTP1B, NSC406239, AC1Q638Q, ...
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Disease relevance of Sorbitan monooleate


High impact information on Sorbitan monooleate

  • Non-ionic surfactants prevented the interfacially induced aggregation at their critical micelle concentration (cmc) for Pluronic F-68 (polyoxyethylene polyoxypropylene block polymer) and Brij 35 (polyoxyethylene alkyl ether) and above the cmc for Tween 80 (polyoxyethylene sorbitan monooleate) [6].
  • In order to provide a suitable device that would contain water-soluble drugs, highly water-soluble gadolinium diethylenetriaminopentaacetic acid-loaded chitosan microspheres (CMS-Gd-DTPA) were prepared by the emulsion method using glutaraldehyde as a cross-linker and Span 80 as a surfactant for gadolinium neutron-capture therapy of cancer [7].
  • These properties enabled prolonged release of Lys for up to 2 months, characterized by a minimal initial burst of Lys and nearly zero-order protein release kinetics result from co-administration of sorbitan monooleate 80 [8].
  • A total of 48 kg of TPH (about 88% of the initial TPH) was removed from the pilot site with five pore volumes of 2% sorbitan monooleate solution flushing; this total was more than 75 times the amount that was removed when flushing with water alone (less than 640 g) [9].
  • This work evaluated the flushing efficiency of tetrachloroethylene (PCE) using the co-surfactant of non-ionic ethoxylated sorbitan ester (Tween) and oilphilic sorbitan monooleate (Span 80), which formed more hydrophobic micelles than Tween alone [10].

Chemical compound and disease context of Sorbitan monooleate

  • Acid-producing activity and viability of the liquid concentrated culture of Lactobacillus bulgaricus 1067 were markedly improved only when the cells were grown in a medium supplemented with Span 80 and then stored with .1% sodium ascorbate after addition of bubbling N2 into the culture [11].
  • Short-term toxicity study of sorbitan mono-oleate (Span 80) in rats [12].

Biological context of Sorbitan monooleate

  • Thus, the highest skin permeation rate (4.14 micrograms/cm2/hr) was achieved when 2% TS was loaded in DuroTak 87-2516 together with 10% Span 80 and 3% dodecylamine, the permeation enhancer [13].
  • We developed cationic lipid vesicles consisting mainly of sorbitan monooleate (Span 80) and cationic peptide lipid (CPL), and evaluated the CPL vesicles as gene transfection vectors [14].

Anatomical context of Sorbitan monooleate


Associations of Sorbitan monooleate with other chemical compounds

  • Batch experiments were performed to determine the equilibrium solubilization capacity of the surfactant, polyoxyethylene (20) sorbitan monooleate (Tween 80), and to measure fluid viscosity, density and interfacial tension [17].
  • Particle size, shape, and surface morphology were significantly affected by guar gum concentration, glutaraldehyde concentration, emulsifier concentration (Span 80), stirring rate, stirring time, and operating temperature [18].
  • The effects, on loading efficiency, microsphere yield, morphology and drug release, of two dispersing agents, aluminium tristearate and Span 80, in mineral oil were examined [19].

Gene context of Sorbitan monooleate

  • Addition of increasing concentrations of sorbitan monooleate (Span 80) to suspensions of micronized polar solids in model CFC suspensions caused marked changes in aggregate morphology and suspension stability [20].
  • BSA-loaded mcirospheres were prepared by a modified phase separation method, in which petroleum ether (PE) containing a certain amount of Span 80 rather than poly (dimethylsiloxane) (PDMS) was adopted as coacervating agent [21].

Analytical, diagnostic and therapeutic context of Sorbitan monooleate

  • After a 4-h period during which feed was withheld, pigs were force-fed 6 mL of nonemulsified (NE) MCT or 20 mL of a 30% (vol/vol) Tween 80-(polyoxy-ethylene [20] sorbitan monooleate) MCT emulsion, marking time 0, and serial blood samples were drawn throughout 8 h for analysis of medium-chain fatty acid (MCFA) concentrations by HPLC [22].


  1. Possible involvement of a calcium-stimulated ATP-hydrolyzing activity associated with mycobacteriophage I3 in the DNA injection process. Karnik, S.S., Gopinathan, K.P. J. Virol. (1980) [Pubmed]
  2. Effects of surfactant mixtures, including Corexit 9527, on bacterial oxidation of acetate and alkanes in crude oil. Bruheim, P., Bredholt, H., Eimhjellen, K. Appl. Environ. Microbiol. (1999) [Pubmed]
  3. Mycobacteriocins produced by rapidly growing mycobacteria are Tween-hydrolyzing esterases. Saito, H., Tomioka, H., Watanabe, T., Yoneyama, T. J. Bacteriol. (1983) [Pubmed]
  4. Effects of polyoxyethylene (20) sorbitan monooleate on the acute toxicity of linear alkylbenzenesulfonate (C12LAS) to fish. Toshima, Y., Moriya, T., Yoshimura, K. Ecotoxicol. Environ. Saf. (1992) [Pubmed]
  5. Allergic contact dermatitis to sorbitan monooleate (Span 80). Austad, J. Contact Derm. (1982) [Pubmed]
  6. Effect of surfactants on the physical stability of recombinant human growth hormone. Katakam, M., Bell, L.N., Banga, A.K. Journal of pharmaceutical sciences. (1995) [Pubmed]
  7. Gadolinium diethylenetriaminopentaacetic acid-loaded chitosan microspheres for gadolinium neutron-capture therapy. Saha, T.K., Ichikawa, H., Fukumori, Y. Carbohydr. Res. (2006) [Pubmed]
  8. In vitro study of lysozyme in poly(lactide-co-glycolide) microspheres with sucrose acetate isobutyrate. Lee, E.S., Kwon, M.J., Lee, H., Na, K., Kim, J.J. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2006) [Pubmed]
  9. Application of nonionic surfactant-enhanced in situ flushing to a diesel contaminated site. Lee, M., Kang, H., Do, W. Water Res. (2005) [Pubmed]
  10. Co-surfactant of ethoxylated sorbitan ester and sorbitan monooleate for enhanced flushing of tetrachloroethylene. Yeh, C.K., Peng, S.L., Hsu, I.Y. Chemosphere (2002) [Pubmed]
  11. Influences of cellular components and redox potential of liquid concentrated culture of Lactobacillus bulgaricus on acid-producing activity and viability. Kaneko, T., Suzuki, H., Takahashi, T. J. Dairy Sci. (1987) [Pubmed]
  12. Short-term toxicity study of sorbitan mono-oleate (Span 80) in rats. Ingram, A.J., Butterworth, K.R., Gaunt, I.F., Grasso, P., Gangolli, S.D. Food and cosmetics toxicology. (1978) [Pubmed]
  13. The effects of pressure-sensitive adhesives and solubilizers on the skin permeation of testosterone from a matrix-type transdermal delivery system. Zhao, H., Park, D.W., Kim, S.K., Lee, C.H., Kim, D.D. Drug development and industrial pharmacy. (2002) [Pubmed]
  14. Gene transfection into HeLa cells by vesicles containing cationic peptide lipid. Ohama, Y., Heike, Y., Sugahara, T., Sakata, K., Yoshimura, N., Hisaeda, Y., Hosokawa, M., Takashima, S., Kato, K. Biosci. Biotechnol. Biochem. (2005) [Pubmed]
  15. Experimental Corynebacterium pseudotuberculosis infection in lambs. Brogden, K.A., Cutlip, R.C., Lehmkuhl, H.D. Am. J. Vet. Res. (1984) [Pubmed]
  16. Microemulsions of triglyceride-based oils: The effect of co-oil and salinity on phase diagrams. Komesvarakul, N., Sanders, M.D., Szekeres, E., Acosta, E.J., Faller, J.F., Mentlik, T., Fisher, L.B., Nicoll, G., Sabatini, D.A., Scamehorn, J.F. Journal of cosmetic science. (2006) [Pubmed]
  17. Surfactant enhanced recovery of tetrachloroethylene from a porous medium containing low permeability lenses. 1. Experimental studies. Taylor, T.P., Pennell, K.D., Abriola, L.M., Dane, J.H. J. Contam. Hydrol. (2001) [Pubmed]
  18. Cross-linked guar gum microspheres: a viable approach for improved delivery of anticancer drugs for the treatment of colorectal cancer. Chaurasia, M., Chourasia, M.K., Jain, N.K., Jain, A., Soni, V., Gupta, Y., Jain, S.K. AAPS PharmSciTech [electronic resource]. (2006) [Pubmed]
  19. Microencapsulation of ovalbumin in poly(lactide-co-glycolide) by an oil-in-oil (o/o) solvent evaporation method. Uchida, T., Yagi, A., Oda, Y., Goto, S. Journal of microencapsulation. (1996) [Pubmed]
  20. Characterization of surfactant effect on aggregates in model aerosol propellent suspensions. Bower, C., Washington, C., Purewal, T.S. J. Pharm. Pharmacol. (1996) [Pubmed]
  21. Preparation of bovine serum albumin loaded poly (D, L-lactic-co-glycolic acid) microspheres by a modified phase separation technique. Zhang, J.X., Zhu, K.J., Chen, D. Journal of microencapsulation. (2005) [Pubmed]
  22. Emulsification and fatty-acid chain length affect the utilization of medium-chain triglycerides by neonatal pigs. Wieland, T.M., Lin, X., Odle, J. J. Anim. Sci. (1993) [Pubmed]
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