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Chemical Compound Review

Sorbitan     (3S)-2-(1,2- dihydroxyethyl)oxolane-3,4- diol

Synonyms: SureCN1387, KST-1B4800, AR-1B7445, AC1L2U2Y, AC1Q774T, ...
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Disease relevance of Sorbitan


Psychiatry related information on Sorbitan


High impact information on Sorbitan


Chemical compound and disease context of Sorbitan


Biological context of Sorbitan

  • The effects of an ethoxylated sorbitan fatty ester nonionic surfactant (Tween 80) on the bioavailability of polycyclic aromatic hydrocarbons (PAHs) were examined by using soil-free and dense-slurry (67% solids content, by wt) systems containing a creosote-contaminated field soil [12].
  • Effect of oxyethylene moiety in polyoxyethylene sorbitan esters on the pharmacokinetics of menatetrenone incorporated in O/W lipid emulsions prepared with polyoxyethylene sorbitan esters and soybean oil in rats [13].

Anatomical context of Sorbitan

  • In an attempt to explain the rather short half-life of molecules at the injection site after their intra-muscular administration in a sorbitan monostearate organogel, in vitro studies were carried out to study the effects of an aqueous medium (simulating interstitial fluid at injection site) on the physical form of the organogel [14].
  • Cationic niosomes of sorbitan monoesters were prepared using film hydration method and tested for their effect on delivery of antisense oligonucleotides (OND) in a COS-7 cell line [15].
  • The ester linkage of PEG Sorbitan fatty acid esters was hydrolyzed after oral administration, and the PEG Sorbitan moiety was poorly absorbed from the gastrointestinal tract [16].

Associations of Sorbitan with other chemical compounds

  • Sorbitan trioleate (Span 85) modified by Cibacron Blue F-3GA (CB) was prepared and used as an affinity surfactant to formulate a reversed micellar system for Candida rugosa lipase (CRL) solubilization [17].
  • NSVs were prepared from polyoxyethylene sorbitan monolaurate (Tween20) and cholesterol [18].
  • In niosomes containing PGDS, myristyl alcohol (MA), and polysorbate, the fatty acid chain length of polyoxyethylene sorbitan ester-type surfactants has influenced the release rate and encapsulation efficiency [19].
  • The effects of alkyl chain length of fatty alcohols (C(12), C(14), C(16), C(18), and C(16+18)), of acyl chain length of polyoxyethylene sorbitan monoester surfactants, and of the molar ratio of lipid mixture on the release rate of ketorolac from niosomes were assessed by employing modified dissolution-dialysis method [19].
  • In this study, we investigated the optimum conditions under which the enzymatic synthesis of sorbitan methacrylate can be affected using Novozym 435 in t-butanol from sorbitan and several acyl donors (ethyl methacrylate, methyl methacrylate, and vinyl methacrylate) [6].

Gene context of Sorbitan

  • The displacement of a globular protein (bovine serum albumin, BSA) from the surface of oil droplets in concentrated oil-in-water emulsions by a nonionic surfactant (polyoxyethylene sorbitan monolauarate, Tween 20) was studied using front-face fluorescence spectroscopy (FFFS) [20].

Analytical, diagnostic and therapeutic context of Sorbitan


  1. A test for measuring growth responses of mollicutes to serum and polyoxyethylene sorbitan. Rose, D.L., Tully, J.G., Bové, J.M., Whitcomb, R.F. Int. J. Syst. Bacteriol. (1993) [Pubmed]
  2. Contact urticaria syndrome from sorbitan sesquioleate in a corticosteroid ointment. Hardy, M.P., Maibach, H.I. Contact Derm. (1995) [Pubmed]
  3. Contact dermatitis due to sorbitan monolaurate. Finn, O.A., Forsyth, A. Contact Derm. (1975) [Pubmed]
  4. Effects of polyoxyethylene (20) sorbitan monooleate on the acute toxicity of linear alkylbenzenesulfonate (C12LAS) to fish. Toshima, Y., Moriya, T., Yoshimura, K. Ecotoxicol. Environ. Saf. (1992) [Pubmed]
  5. Emulsifier content and side effects of oil-based adjuvant vaccine in swine. Oda, K., Tsukahara, F., Kubota, S., Kida, K., Kitajima, T., Hashimoto, S. Res. Vet. Sci. (2006) [Pubmed]
  6. Enzymatic synthesis of sorbitan methacrylate according to acyl donors. Jeong, G.T., Lee, H.J., Kim, H.S., Park, D.H. Appl. Biochem. Biotechnol. (2006) [Pubmed]
  7. Online concentration by field-amplified sample injection in acidic buffer for analysis of fangchinoline and tetrandrine in herbal medicine by flow injection-micellar electrokinetic capillary chromatography. Liu, L., Chen, X., Hu, Z. Electrophoresis (2005) [Pubmed]
  8. Flavin mononucleotide sensitized and polyoxyethylene (20) sorbitan trioleate micelle-enhanced gas/solution chemiluminescence for direct continuous monitoring of sulfur dioxide in the atmosphere. Kato, M., Yamada, M., Suzuki, S. Anal. Chem. (1984) [Pubmed]
  9. Tween 20 detaches cardiolipin from ELISA plates and makes anticardiolipin antibodies undetectable regardless of the presence of beta 2-glycoprotein-I. Cabral, A.R., Cabiedes, J., Alarcón-Segovia, D. J. Immunol. Methods (1994) [Pubmed]
  10. Percutaneous absorption of flufenamic acid in rabbits: effect of dimethyl sulfoxide and various nonionic surface-active agents. Hwang, C.C., Danti, A.G. Journal of pharmaceutical sciences. (1983) [Pubmed]
  11. Prevalence and sources of sensitization to emulsifiers: a clinical study. Tosti, A., Guerra, L., Morelli, R., Bardazzi, F. Contact Derm. (1990) [Pubmed]
  12. Polycyclic aromatic hydrocarbon behavior in bioactive soil slurry reactors amended with a nonionic surfactant. Kim, H.S., Weber, W.J. Environ. Toxicol. Chem. (2005) [Pubmed]
  13. Effect of oxyethylene moiety in polyoxyethylene sorbitan esters on the pharmacokinetics of menatetrenone incorporated in O/W lipid emulsions prepared with polyoxyethylene sorbitan esters and soybean oil in rats. Ueda, K., Fujimoto, M., Noto, H., Kawaguchi, Y., Sakaeda, T., Iwakawa, S. J. Pharm. Pharmacol. (2002) [Pubmed]
  14. Interaction of a nonionic surfactant-based organogel with aqueous media. Murdan, S., Gregoriadis, G., Florence, A.T. International journal of pharmaceutics. (1999) [Pubmed]
  15. Cationic niosomes as gene carriers: preparation and cellular uptake in vitro. Huang, Y.Z., Han, G., Wang, H., Liang, W.Q. Die Pharmazie. (2005) [Pubmed]
  16. Final report on the safety assessment of PEG-6, -8, and -20 sorbitan beeswax. Lanigan, R.S., Yamarik, T.A. International journal of toxicology. (2001) [Pubmed]
  17. Characterization of Lipase in Reversed Micelles Formulated with Cibacron Blue F-3GA Modified Span 85. Zhang, D.H., Guo, Z., Dong, X.Y., Sun, Y. Biotechnol. Prog. (2007) [Pubmed]
  18. Lidocaine-loaded non-ionic surfactant vesicles: characterization and in vitro permeation studies. Carafa, M., Santucci, E., Lucania, G. International journal of pharmaceutics. (2002) [Pubmed]
  19. Release studies on niosomes containing Fatty alcohols as bilayer stabilizers instead of cholesterol. Devaraj, G.N., Parakh, S.R., Devraj, R., Apte, S.S., Rao, B.R., Rambhau, D. Journal of colloid and interface science. (2002) [Pubmed]
  20. Front-face fluorescence spectroscopy study of globular proteins in emulsions: displacement of BSA by a nonionic surfactant. Rampon, V., Genot, C., Riaublanc, A., Anton, M., Axelos, M.A., McClements, D.J. J. Agric. Food Chem. (2003) [Pubmed]
  21. Sorbitan tristearate layers at the air/water interface studied by shear and dilatational interfacial rheology. Erni, P., Fischer, P., Windhab, E.J. Langmuir : the ACS journal of surfaces and colloids. (2005) [Pubmed]
  22. Testing with fragrance mix. Is the addition of sorbitan sesquioleate to the constituents useful? Frosch, P.J., Pilz, B., Burrows, D., Camarasa, J.G., Lachapelle, J.M., Lahti, A., Menné, T., Wilkinson, J.D. Contact Derm. (1995) [Pubmed]
  23. Determination of sorbitan trioleate in metered-dose inhalers by supercritical-fluid chromatography. Di Maso, M., Purdy, W.C., McClintock, S.A., Cotton, M.L. Journal of pharmaceutical and biomedical analysis. (1990) [Pubmed]
  24. Effects of sorbitan sesquioleate on non-immunologic immediate contact reactions to benzoic acid. Larmi, E., Lahti, A., Hannuksela, M. Contact Derm. (1988) [Pubmed]
  25. Particle size and loading efficiency of poly(D,L-lactic-co-glycolic acid) multiphase microspheres containing water soluble substances prepared by the hydrous and anhydrous solvent evaporation methods. Iwata, M., Nakamura, Y., McGinity, J.W. Journal of microencapsulation. (1999) [Pubmed]
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