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Chemical Compound Review:

PICLORAM 4-amino-3,5,6-trichloro- pyridine-2...

Synonyms: Borolin, Piclorame, Access, Grazon, Tordon, ...

Oakes, D.J. et al., Pereira, L.F. et al., Mayes, M.A. et al.

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Disease relevance of PICLORAM

Toxicity of picloram (4-amino-3,5,6-trichloropicolinic acid) to life stages of the rainbow trout [1].

High impact information on PICLORAM

The results show that the toxic effects of Tordon 75D on SMPs (at the EC50) and intact rat liver mitochondria were not due to any additive or synergistic actions of a mixture of its active and other components, but rather were caused solely by the proprietary surfactant [2].
The results showed that Tordon 75D (a mixture of the triisopropanolamine salts of 2,4-dichlorophenoxy acetic acid (2,4-D) and 4-amino-3,5,6-trichloropicolinic acid (picloram) and its other components) impaired the oxidative functions of submitochondrial particles (SMPs) [2].
Effects of a herbicide formulation, Tordon 75D, and its individual components on the oxidative functions of mitochondria [2].
These results characterize an interaction of Tordon with complex I of the respiratory chain and also a partial collapse of the proton motive force of the mitochondrial inner membrane without affecting its elasticity [3].

References

Toxicity of picloram (4-amino-3,5,6-trichloropicolinic acid) to life stages of the rainbow trout. Mayes, M.A., Hopkins, D.L., Dill, D.C. Bulletin of environmental contamination and toxicology. (1987) [Pubmed]
Effects of a herbicide formulation, Tordon 75D, and its individual components on the oxidative functions of mitochondria. Oakes, D.J., Pollack, J.K. Toxicology (1999) [Pubmed]
Effect of Tordon 2,4-D 64/240 triethanolamine BR on the energy metabolism of rat liver mitochondria. Pereira, L.F., Campello, A.P., Silveira, O. Journal of applied toxicology : JAT. (1994) [Pubmed]

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