Disease relevance of Bryonolic acid

• Bryonolic acid showed strong inhibition of the growth of B-16 melanoma cells [1].
• Bryonolic acid production in hairy roots of Trichosanthes kirilowii Max. var Japonica Kitam. Transformed with Agrobacterium rhizogenes and its cytotoxic activity [1].

High impact information on Bryonolic acid

• The anti-allergic activity of bryonolic acid (1) isolated from the cultured cells of Luffa cylindrica L [2].
• Furthermore, cell fractionation and electron microscopic studies on subcellular structures of luffa cells suggested that minute vesicles originating from elongated, rough endoplasmic reticulum probably play an important role in the transport of bryonolic acid which largely accumulates in the cell wall of cultured cells [3].
• The appearance of a DNA ladder was detected in the bryonolic acid-treated HL-60RG cells, indicating that cell death triggered by bryonolic acid is due to apoptosis [4].
• Normal cells such as rat hepatocytes are less sensitive to bryonolic acid [4].

Analytical, diagnostic and therapeutic context of Bryonolic acid

• The levels of isomultiflorenol synthase and cycloartenol synthase mRNAs, which were measured with gene-specific probes, correlated with the accumulation of bryonolic acid and phytosterols over a growth cycle of the Luffa cell cultures [5].
• Molecular cloning and characterization of isomultiflorenol synthase, a new triterpene synthase from Luffa cylindrica, involved in biosynthesis of bryonolic acid [5].

References