The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Luffa

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Luffa

  • This is consistent with LcIMS1 encoding isomultiflorenol synthase, an oxidosqualene cyclase involved in bryonolic acid biosynthesis in cultured Luffa cells [1].
  • An oxidosqualene cyclase cDNA, LcIMS1, was isolated from cultured cells of Luffa cylindrica Roem. by heterologous hybridization with cDNA of Glycyrrhiza glabra beta-amyrin synthase [1].
  • Competitive inhibition studies indicate no immunological crossreactivity between the inhibitory protein from Luffa aegyptiaca, pokeweed antiviral protein (PAP) and recombinant ricin A chain [2].
  • However, there was a small degree of resemblance to cyclophilins and a considerable extent of identity to the 6.5 kDa arginine/glutamate-rich polypeptide from Luffa cylindrica seeds [3].
  • The dried alcoholic (50%) extract of the plant Luffa echinata was investigated for inhibition of lipid peroxidation, for hydroxyl radical scavenging activity and interaction with 1,1-diphenyl-2-picrylhydrazyl stable free radical (DPPH) [4].
 

Biological context of Luffa

  • Identification of lysine residue at or near active site of luffin-a, a ribosome-inactivating protein from seeds of Luffa cylindrica [5].
 

Anatomical context of Luffa

 

Associations of Luffa with chemical compounds

  • Anti-allergic effect of bryonolic acid from Luffa cylindrica cell suspension cultures [6].
  • High fidelity calcium carbonate and hydroxyapatite (bio) inorganic replicas of the fibrous network of the dried fruit of Luffa cylindrica are described, utilizing a facile synthetic route [9].
  • Chlorella sorokiniana immobilized on the biomatrix of vegetable sponge of Luffa cylindrica: a new system to remove cadmium from contaminated aqueous medium [10].
  • The homeopathic remedy (Luffa comp.-Heel trade mark Nasal Spray, dosage: 0.14 ml per application, 4 times per a day / naris) consisted of a fixed combination made up of Luffa operculata, Galphimia glauca, histamine, and sulfur [11].
  • Luffin from Luffa cylindrica seeds has been successfully incorporated into lecithin/cholesterol and lecithin/cholesterol/dicetylphosphate negatively charged liposomes [12].
 

Gene context of Luffa

 

Analytical, diagnostic and therapeutic context of Luffa

  • Molecular cloning and characterization of isomultiflorenol synthase, a new triterpene synthase from Luffa cylindrica, involved in biosynthesis of bryonolic acid [1].
  • The levels of isomultiflorenol synthase and cycloartenol synthase mRNAs, which were measured with gene-specific probes, correlated with the accumulation of bryonolic acid and phytosterols over a growth cycle of the Luffa cell cultures [1].
  • A glycoprotein with a molecular weight of 28,000 as estimated by SDS-polyacrylamide gel electrophoresis was isolated from seeds of Luffa acutangula using a procedure that involved acetone precipitation, ion exchange chromatography on CM Sepharose CL-6B and gel filtration on Sephadex G-50 [16].

References

  1. Molecular cloning and characterization of isomultiflorenol synthase, a new triterpene synthase from Luffa cylindrica, involved in biosynthesis of bryonolic acid. Hayashi, H., Huang, P., Inoue, K., Hiraoka, N., Ikeshiro, Y., Yazaki, K., Tanaka, S., Kushiro, T., Shibuya, M., Ebizuka, Y. Eur. J. Biochem. (2001) [Pubmed]
  2. Characterization of a translation inhibitory protein from Luffa aegyptiaca. Ramakrishnan, S., Enghlid, J.J., Bryant, H.L., Xu, F.J. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  3. Isolation of lilin, a novel arginine- and glutamate-rich protein with potent antifungal and mitogenic activities from lily bulbs. Wang, H., Ng, T.B. Life Sci. (2002) [Pubmed]
  4. Effect of Luffa echinata on lipid peroxidation and free radical scavenging activity. Kumar, V.P., Shashidhara, S., Kumar, M.M., Sridhara, B.Y. J. Pharm. Pharmacol. (2000) [Pubmed]
  5. Identification of lysine residue at or near active site of luffin-a, a ribosome-inactivating protein from seeds of Luffa cylindrica. Watanabe, K., Suemasu, Y., Funatsu, G. J. Biochem. (1989) [Pubmed]
  6. Anti-allergic effect of bryonolic acid from Luffa cylindrica cell suspension cultures. Tanaka, S., Uno, C., Akimoto, M., Tabata, M., Honda, C., Kamisako, W. Planta Med. (1991) [Pubmed]
  7. Anti-complement activity of oleanolic acid: an inhibitor of C3-convertase of the classical complement pathway. Kapil, A., Sharma, S. J. Pharm. Pharmacol. (1994) [Pubmed]
  8. Production of an anti-allergic triterpene bryonolic acid, by plant cell cultures. Tabata, M., Tanaka, S., Cho, H.J., Uno, C., Shimakura, J., Ito, M., Kamisako, W., Honda, C. J. Nat. Prod. (1993) [Pubmed]
  9. Morphosynthesis: high fidelity inorganic replica of the fibrous network of loofa sponge (Luffa cylindrica). Mazali, I.O., Alves, O.L. An. Acad. Bras. Cienc. (2005) [Pubmed]
  10. Chlorella sorokiniana immobilized on the biomatrix of vegetable sponge of Luffa cylindrica: a new system to remove cadmium from contaminated aqueous medium. Akhtar, N., Saeed, A., Iqbal, M. Bioresour. Technol. (2003) [Pubmed]
  11. A randomized equivalence trial comparing the efficacy and safety of Luffa comp.-Heel nasal spray with cromolyn sodium spray in the treatment of seasonal allergic rhinitis. Weiser, M., Gegenheimer, L.H., Klein, P. Forschende Komplementärmedizin. (1999) [Pubmed]
  12. Antiproliferative effect and apoptotic response in vitro of human melanoma cells to liposomes containing the ribosome-inactivating protein luffin. Poma, A., Marcozzi, G., Cesare, P., Carmignani, M., Spanò, L. Biochim. Biophys. Acta (1999) [Pubmed]
  13. Isolation and fusion studies on protoplasts from pollen tetrads. Deka, P.C., Mehar, A.K., Pathak, N.N., Sen, S.K. Experientia (1977) [Pubmed]
  14. Continuous methane fermentation and the production of vitamin B12 in a fixed-bed reactor packed with loofah. Yang, Y., Zhang, Z., Lu, J., Maekawa, T. Bioresour. Technol. (2004) [Pubmed]
  15. Primary structure of 6.5k-arginine/glutamate-rich polypeptide from the seeds of sponge gourd (Luffa cylindrica). Kimura, M., Park, S.S., Sakai, R., Yamasaki, N., Funatsu, G. Biosci. Biotechnol. Biochem. (1997) [Pubmed]
  16. Isolation of a ribosome-inactivating and abortifacient protein from seeds of Luffa acutangula. Yeung, H.W., Li, W.W., Ng, T.B. Int. J. Pept. Protein Res. (1991) [Pubmed]
 
WikiGenes - Universities