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Chemical Compound Review:

SureCN399281 [(2S,3R,5S,6R)-2,3,4,5,6...

Synonyms: AG-K-71466, SureCN3472015, SureCN7947628, CHEBI:37493, CHEBI:62383, ...

Ross, T.S. et al., Perron, B. et al., Ross, T.S. et al., Miyazawa, A. et al., Smith, C.D. et al., et al.

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Disease relevance of L-myo-Inositol 5-phosphate

Mammalian cells that express Bacillus cereus phosphatidylinositol-specific phospholipase C have increased levels of inositol cyclic 1:2-phosphate, inositol 1-phosphate, and inositol 2-phosphate [1].
Histologic study of the inhibition of bone resorption in organ cultures by myo-inositol-2-monophosphate [2].

High impact information on L-myo-Inositol 5-phosphate

Annexin III, a putative inositol (1,2)-phosphohydrolase, was co-crystallized with inositol 2-phosphate, the inhibitor of the reaction, and its structure was solved to 1.95 A resolution [3].
The enzyme was inhibited by inositol 2-phosphate (IC50 = 4 microM) and to a lesser degree by inositol 1-phosphate (IC50 = 2 mM) and inositol (IC50 = 4 mM) [4].
Hydrolysis was stimulated by putrescine, and was inhibited by inositol 2-phosphate, spermidine, spermine, and neomycin [5].
No cross-reaction with other structural analogs such as inositol 1-monophosphate and inositol 2-monophosphate was observed [6].

References

Mammalian cells that express Bacillus cereus phosphatidylinositol-specific phospholipase C have increased levels of inositol cyclic 1:2-phosphate, inositol 1-phosphate, and inositol 2-phosphate. Ross, T.S., Wang, F.P., Majerus, P.W. J. Biol. Chem. (1992) [Pubmed]
Histologic study of the inhibition of bone resorption in organ cultures by myo-inositol-2-monophosphate. Gomes, B.C., Kaufman, H.W., Archard, H.O., Cangemi, C., Guerra, A. J. Oral Pathol. (1986) [Pubmed]
Can enzymatic activity, or otherwise, be inferred from structural studies of annexin III? Perron, B., Lewit-Bentley, A., Geny, B., Russo-Marie, F. J. Biol. Chem. (1997) [Pubmed]
Isolation of D-myo-inositol 1:2-cyclic phosphate 2-inositolphosphohydrolase from human placenta. Ross, T.S., Majerus, P.W. J. Biol. Chem. (1986) [Pubmed]
Characterization of a phosphatidylinositol 4-phosphate-specific phosphomonoesterase in rat liver nuclear envelopes. Smith, C.D., Wells, W.W. Arch. Biochem. Biophys. (1984) [Pubmed]
Production and characterization of monoclonal antibodies that bind to phosphatidylinositol 4,5-bisphosphate. Miyazawa, A., Umeda, M., Horikoshi, T., Yanagisawa, K., Yoshioka, T., Inoue, K. Mol. Immunol. (1988) [Pubmed]

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