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Chemical Compound Review

Gesamoos     3-[4-(4- chlorophenoxy)phenyl]-1,1- dimethyl...

Synonyms: TENORAN, CHLOROXURON, Norex, Chlorphencarb, SureCN132843, ...
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High impact information on Gesamoos

  • The corrected gene-deduced amino acid sequence has 45% overall identity with alpha 1-protease inhibitor, which is higher than the 42% previously reported (Chandra, T., Stackhouse, R., Kidd, V. J., Robson, J. H., and Woo, S. L. C. (1983) Biochemistry 22, 5055-5060) [1].
  • This protein was shown by peptide mapping and immunological criteria to be identical to the prominent CaM-PK III substrate previously identified in a number of mammalian cells and tissues (Palfrey, H. C. (1983) FEBS Lett. 157, 183-190; Nairn, A.C., Bhagat, B., and Palfrey, H.C. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 7939-7943) [2].
  • Together with the previously published sequence of the mouse 59-kDa type I keratin (Steinert, P. M., Rice, R. H., Roop, D. R., Trus, B. L., and Steven, A. C. (1983) Nature 302, 794-800) these data allow us to make comparisons between two keratins which are coexpressed in an epithelial cell type and which coassemble into the same IF [3].
  • The basic residue, Arg-16, was found to have a strong influence on the kinetics of phosphorylation similar to that reported previously for the three adjacent residues, Lys-11, Lys-12, and Lys-13 (Kemp, B. E., Pearson, R. B., and House, C. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 7471-7475) [4].
  • This is accomplished via activation of an amiloride-sensitive Na+-uptake system ( Rosoff , P. M., and Cantley , L. C. (1983) Proc. Natl. Acad. Sci. U.S.A. 80, 7547-7550) [5].

Anatomical context of Gesamoos

  • A polymerization mechanism similar to that proposed at this pH [Frieden, C. (1983) Proc. Natl. Acad. Sci. U.S.A. 80, 6513-6517] was found to fit the data from 10 to 35 degrees C. From the kinetic data, no evidence for actin filament fragmentation was found at any temperature [6].
  • These data parallel those of an accompanying paper (Cocito, C., Vanlinden, F. and Branlant, C. (1983) Biochim. Biophys. Acta 739, 158-163) showing the intactness of all rRNA species from ribosomes treated in vivo and in vitro with virginiamycin M [7].

Gene context of Gesamoos

  • We demonstrated previously that the hormonal induction in kidney is the result of an increase in ornithine aminotransferase mRNA levels (Mueckler, M. M., and Pitot, H. C. (1983) J. Biol. Chem. 258, 1781-1784) [8].
  • These substrates have been used with the FMN-containing biosynthetic dihydroorotate oxidase from Crithidia fasciculata [Pascal, R., Trang, N., Cerami, A., & Walsh, C. (1983) Biochemistry 22, 171] to probe stereochemistry and mechanism [9].

Analytical, diagnostic and therapeutic context of Gesamoos


  1. Cloning, expression, purification, and biological activity of recombinant native and variant human alpha 1-antichymotrypsins. Rubin, H., Wang, Z.M., Nickbarg, E.B., McLarney, S., Naidoo, N., Schoenberger, O.L., Johnson, J.L., Cooperman, B.S. J. Biol. Chem. (1990) [Pubmed]
  2. Rapid activation of calmodulin-dependent protein kinase III in mitogen-stimulated human fibroblasts. Correlation with intracellular Ca2+ transients. Palfrey, H.C., Nairn, A.C., Muldoon, L.L., Villereal, M.L. J. Biol. Chem. (1987) [Pubmed]
  3. Amino acid sequences of mouse and human epidermal type II keratins of Mr 67,000 provide a systematic basis for the structural and functional diversity of the end domains of keratin intermediate filament subunits. Steinert, P.M., Parry, D.A., Idler, W.W., Johnson, L.D., Steven, A.C., Roop, D.R. J. Biol. Chem. (1985) [Pubmed]
  4. Spatial requirements for location of basic residues in peptide substrates for smooth muscle myosin light chain kinase. Kemp, B.E., Pearson, R.B. J. Biol. Chem. (1985) [Pubmed]
  5. Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange. Rosoff, P.M., Stein, L.F., Cantley, L.C. J. Biol. Chem. (1984) [Pubmed]
  6. Effect of temperature on the mechanism of actin polymerization. Zimmerle, C.T., Frieden, C. Biochemistry (1986) [Pubmed]
  7. The lasting ribosome alteration produced by virginiamycin M disappears upon removal of certain ribosomal proteins. Moureau, P., Di Giambattista, M., Cocito, C. Biochim. Biophys. Acta (1983) [Pubmed]
  8. Transcriptional control of ornithine aminotransferase synthesis in rat kidney by estrogen and thyroid hormone. Mueckler, M.M., Moran, S., Pitot, H.C. J. Biol. Chem. (1984) [Pubmed]
  9. Mechanistic studies with deuterated dihydroorotates on the dihydroorotate oxidase from Crithidia fasciculata. Pascal, R.A., Walsh, C.T. Biochemistry (1984) [Pubmed]
  10. Distribution of plasma kallikrein between C-1 inactivator and alpha 2-macroglobulin in plasma utilizing a new assay for alpha 2-macroglobulin-kallikrein complexes. Harpel, P.C., Lewin, M.F., Kaplan, A.P. J. Biol. Chem. (1985) [Pubmed]
  11. Determination of chloroxuron in strawberries using liquid chromatography with electron-capture detection. Maris, F.A., Geerdink, R.B., van Delft, R., Brinkman, U.A. Bulletin of environmental contamination and toxicology. (1985) [Pubmed]
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