Gene Review:
SERPINA1 - serpin peptidase inhibitor, clade A (alpha...
Homo sapiens
Synonyms:
A1A, A1AT, AAT, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, ...
- Epstein-Barr virus/human vector provides high-level, long-term expression of alpha1-antitrypsin in mice. Stoll, S.M., Sclimenti, C.R., Baba, E.J., Meuse, L., Kay, M.A., Calos, M.P. Mol. Ther. (2001)
- Emphysema associated with complete absence of alpha 1- antitrypsin in serum and the homozygous inheritance [corrected] of a stop codon in an alpha 1-antitrypsin-coding exon. Satoh, K., Nukiwa, T., Brantly, M., Garver, R.I., Hofker, M., Courtney, M., Crystal, R.G. Am. J. Hum. Genet. (1988)
- Identification of a serpin-enzyme complex receptor on human hepatoma cells and human monocytes. Perlmutter, D.H., Glover, G.I., Rivetna, M., Schasteen, C.S., Fallon, R.J. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant. Anderson, E.D., Thomas, L., Hayflick, J.S., Thomas, G. J. Biol. Chem. (1993)
- Proteolytic inactivation of alpha 1-antitrypsin and alpha 1-antichymotrypsin by neutrophils in arthritic joints. Abbink, J.J., Kamp, A.M., Nuijens, J.H., Swaak, T.J., Hack, C.E. Arthritis Rheum. (1993)
- Immunohistochemical localization of lysozyme, lactoferrin, alpha 1-antichymotrypsin, and alpha 1-antitrypsin in salivary gland of human fetuses. Lee, S.K., Lim, C.Y., Chi, J.G., Yamada, K., Kunikata, M., Hashimura, K., Mori, M. Acta Histochem. (1990)
- Association between the PI*M3 allele of alpha 1-antitrypsin and Alzheimer's disease? A preliminary report. Kowalska, A., Danker-Hopfe, H., Wender, M., Florczak, J., Walter, H. Hum. Genet. (1996)
- Survival in relation to lung function and smoking cessation in patients with severe hereditary alpha 1-antitrypsin deficiency. Seersholm, N., Kok-Jensen, A. Am. J. Respir. Crit. Care Med. (1995)
- Antiproteases and Down's syndrome in an Australian population. McPhee, H., Ananthakrishnan, R., Taft, L.I. J. Med. Genet. (1980)
- Long-term follow-up of a cohort of children with alpha-1-antitrypsin deficiency. Wall, M., Moe, E., Eisenberg, J., Powers, M., Buist, N., Buist, A.S. J. Pediatr. (1990)
- Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Jaffe, H.A., Danel, C., Longenecker, G., Metzger, M., Setoguchi, Y., Rosenfeld, M.A., Gant, T.W., Thorgeirsson, S.S., Stratford-Perricaudet, L.D., Perricaudet, M. Nat. Genet. (1992)
- Replacement therapy for alpha 1-antitrypsin deficiency associated with emphysema. Wewers, M.D., Casolaro, M.A., Sellers, S.E., Swayze, S.C., McPhaul, K.M., Wittes, J.T., Crystal, R.G. N. Engl. J. Med. (1987)
- Risk of cirrhosis and primary liver cancer in alpha 1-antitrypsin deficiency. Eriksson, S., Carlson, J., Velez, R. N. Engl. J. Med. (1986)
- Role of alpha-1-antichymotrypsin deficiency in promoting cirrhosis in two siblings with heterozygous alpha-1-antitrypsin deficiency phenotype SZ. Yoon, D., Kueppers, F., Genta, R.M., Klintmalm, G.B., Khaoustov, V.I., Yoffe, B. Gut (2002)
- Immunohistochemical localization of alpha 1-antitrypsin and alpha 1-antichymotrypsin in salivary pleomorphic adenomas. Murase, N., Kobayashi, K., Mitani, H., Mori, M. Virchows Archiv. A, Pathological anatomy and histopathology. (1985)
- Alpha-1-antitrypsin deficiency: a new paradigm for hepatocellular carcinoma in genetic liver disease. Rudnick, D.A., Perlmutter, D.H. Hepatology (2005)
- Recombinant alpha 1-antitrypsin Pittsburgh (Met 358----Arg) is a potent inhibitor of plasma kallikrein and activated factor XII fragment. Schapira, M., Ramus, M.A., Jallat, S., Carvallo, D., Courtney, M. J. Clin. Invest. (1986)
- Glucose removal from N-linked oligosaccharides is required for efficient maturation of certain secretory glycoproteins from the rough endoplasmic reticulum to the Golgi complex. Lodish, H.F., Kong, N. J. Cell Biol. (1984)
- Sequence homology and structural comparison between the chromosomal human alpha 1-antitrypsin and chicken ovalbumin genes. Leicht, M., Long, G.L., Chandra, T., Kurachi, K., Kidd, V.J., Mace, M., Davie, E.W., Woo, S.L. Nature (1982)
- Characterization of the normal alpha 1-antitrypsin allele Vmunich: a variant associated with a unique protein isoelectric focusing pattern. Holmes, M.D., Brantly, M.L., Curiel, D.T., Weidinger, S., Crystal, R.G. Am. J. Hum. Genet. (1990)
- Characterization of the molecular basis of the alpha 1-antitrypsin F allele. Okayama, H., Brantly, M., Holmes, M., Crystal, R.G. Am. J. Hum. Genet. (1991)
- Characterization of the gene and protein of the common alpha 1-antitrypsin normal M2 allele. Nukiwa, T., Brantly, M.L., Ogushi, F., Fells, G.A., Crystal, R.G. Am. J. Hum. Genet. (1988)
- Molecular basis of alpha 1-antitrypsin deficiency and emphysema associated with the alpha 1-antitrypsin Mmineral springs allele. Curiel, D.T., Vogelmeier, C., Hubbard, R.C., Stier, L.E., Crystal, R.G. Mol. Cell. Biol. (1990)
- The acute-phase protein alpha 1-antitrypsin inhibits growth and proliferation of human early erythroid progenitor cells (burst-forming units-erythroid) and of human erythroleukemic cells (K562) in vitro by interfering with transferrin iron uptake. Graziadei, I., Gaggl, S., Kaserbacher, R., Braunsteiner, H., Vogel, W. Blood (1994)
- Development of a transgenic mouse system for the analysis of stages in liver carcinogenesis using tissue-specific expression of SV40 large T-antigen controlled by regulatory elements of the human alpha-1-antitrypsin gene. Sepulveda, A.R., Finegold, M.J., Smith, B., Slagle, B.L., DeMayo, J.L., Shen, R.F., Woo, S.L., Butel, J.S. Cancer Res. (1989)
- Oncostatin M induced alpha1-antitrypsin (AAT) gene expression in Hep G2 cells is mediated by a 3' enhancer. Morgan, K., Marsters, P., Morley, S., van Gent, D., Hejazi, A., Backx, M., Thorpe, E.R., Kalsheker, N. Biochem. J. (2002)
- alpha 1-Antitrypsin- and anchorage-independent growth of MCF-7 breast cancer cells. Finlay, T.H., Tamir, S., Kadner, S.S., Cruz, M.R., Yavelow, J., Levitz, M. Endocrinology (1993)
- Molecular pathology of alpha 1-antitrypsin deficiency and its significance to clinical medicine. Kalsheker, N.A. QJM : monthly journal of the Association of Physicians. (1994)
- Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector. Lu, Y., Choi, Y.K., Campbell-Thompson, M., Li, C., Tang, Q., Crawford, J.M., Flotte, T.R., Song, S. The journal of gene medicine. (2006)
- The hepatic acute-phase proteins alpha 1-antitrypsin and alpha 2-macroglobulin inhibit binding of transferrin to its receptor. Graziadei, I., Kaserbacher, R., Braunsteiner, H., Vogel, W. Biochem. J. (1993)
- Within-subject variation of elastase/alpha 1-protease inhibitor complexes and lactoferrin in plasma. Antonsen, S. Scand. J. Clin. Lab. Invest. (1993)
- Safety and efficacy of recombinant alpha(1)-antitrypsin therapy in cystic fibrosis. Martin, S.L., Downey, D., Bilton, D., Keogan, M.T., Edgar, J., Elborn, J.S. Pediatric pulmonology. (2006)
- Turnover of *I-protein C inhibitor and *I-alpha 1-antitrypsin and their complexes with activated protein C. Laurell, M., Stenflo, J., Carlson, T.H. Blood (1990)
- A method for screening hypochlorous acid scavengers by inhibition of the oxidation of 5-thio-2-nitrobenzoic acid: application to anti-asthmatic drugs. Ching, T.L., de Jong, J., Bast, A. Anal. Biochem. (1994)
- Oxidation of plasma alpha 1-antitrypsin in smokers and nonsmokers and by an oxidizing agent. Cox, D.W., Billingsley, G.D. Am. Rev. Respir. Dis. (1984)
- Function of a rare variant of alpha-1-antitrypsin, phenotype P(i) EFranklin S, a poor inhibitor of human neutrophil elastase. Cook, L., Knight, K.R., Burdon, J.G., Brenton, S., Hunt, J.M. Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. (1997)
- The acute-phase protein alpha 1-antitrypsin inhibits transferrin-receptor binding and proliferation of human skin fibroblasts. Graziadei, I., Kähler, C.M., Wiedermann, C.J., Vogel, W. Biochim. Biophys. Acta (1998)
- SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins. Pak, S.C., Kumar, V., Tsu, C., Luke, C.J., Askew, Y.S., Askew, D.J., Mills, D.R., Brömme, D., Silverman, G.A. J. Biol. Chem. (2004)
- Activated neutrophils secrete stored alpha 1-antitrypsin. Pääkkö, P., Kirby, M., du Bois, R.M., Gillissen, A., Ferrans, V.J., Crystal, R.G. Am. J. Respir. Crit. Care Med. (1996)
- Protease-antiprotease imbalance in the lungs of children with cystic fibrosis. Birrer, P., McElvaney, N.G., Rüdeberg, A., Sommer, C.W., Liechti-Gallati, S., Kraemer, R., Hubbard, R., Crystal, R.G. Am. J. Respir. Crit. Care Med. (1994)