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Chemical Compound Review:

Conopressin G (2S)-1-[[(4S,7S,10S,16S,19S)- 19-amino-7...

Synonyms: AG-K-64507, KST-1B0094, AC1L4TPY, CTK4A7300, AR-1B9560, ...

van Kesteren, R.E. et al., McMaster, D. et al., Martínez-Padrón, M. et al., Kanda, A. et al., Van Soest, P.F. et al.

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Disease relevance of Lys-conopressin

Superfusion of an invertebrate vasopressin structural analogue, conopressin G, over the abdominal ganglion of an in vitro preparation of Aplysia californica has significant neurophysiological and behavioral effects [1].

High impact information on Lys-conopressin

We have cloned a receptor, named LSCPR, for vasopressin-related Lys-conopressin in Lymnaea stagnalis [2].
Upon application of Lys-conopressin, both neurons and muscle cells depolarize owing to an enhancement of voltage-dependent Ca2+ currents and start firing action potentials [2].
Lys-conopressin evokes Ca(2+)-dependent Cl- currents in Xenopus oocytes injected with LSCPR cRNA [2].
Lys-conopressin also induces a depolarizing response in LSCPR-expressing neuroendocrine cells that control carbohydrate metabolism [2].
Based on sequence homologies, Lymnaea conopressin receptors are thought to couple to Q-type G proteins and protein kinase C (PKC) [3].

Biological context of Lys-conopressin

Two genes of the oxytocin/vasopressin superfamily in the cephalopod Octopus vulgaris, cephalotocin (CT) and octopressin (OP), lack introns and consist of a single exon in their protein-coding regions, which is unlike the 2 intron-3 exon structures in most vertebrates and Lys-conopressin in a pond snail Lymnaea stagnalis [4].

Anatomical context of Lys-conopressin

A vasotocin-like peptide in Aplysia kurodai ganglia: HPLC and RIA evidence for its identity with Lys-conopressin G [5].
Both the amplitude of the siphon-evoked gill withdrawal reflux and concomitant activity in gill motor neurons are reduced in the presence of conopressin G [1].

Analytical, diagnostic and therapeutic context of Lys-conopressin

The HPLC/RIA results suggest that (i) based on the properties of the solvent systems used, the A. kurodai peptide has two basic amino acids (like the conopressins but unlike the vertebrate peptides), and (ii) there is a high probability that the A. kurodai peptide is identical with Lys-conopressin G [5].

References

Conopressin G, a molluscan vasopressin-like peptide, alters gill behaviors in Aplysia. Martínez-Padrón, M., Gray, W.R., Lukowiak, K. Can. J. Physiol. Pharmacol. (1992) [Pubmed]
A novel G protein-coupled receptor mediating both vasopressin- and oxytocin-like functions of Lys-conopressin in Lymnaea stagnalis. van Kesteren, R.E., Tensen, C.P., Smit, A.B., van Minnen, J., van Soest, P.F., Kits, K.S., Meyerhof, W., Richter, D., van Heerikhuizen, H., Vreugdenhil, E. Neuron (1995) [Pubmed]
Activation of protein kinase C by oxytocin-related conopressin underlies pacemaker current in Lymnaea central neurons. Van Soest, P.F., Lodder, J.C., Kits, K.S. J. Neurophysiol. (2000) [Pubmed]
Single exon structures of the oxytocin/vasopressin superfamily peptides of octopus. Kanda, A., Takuwa-Kuroda, K., Iwakoshi-Ukena, E., Minakata, H. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
A vasotocin-like peptide in Aplysia kurodai ganglia: HPLC and RIA evidence for its identity with Lys-conopressin G. McMaster, D., Kobayashi, Y., Lederis, K. Peptides (1992) [Pubmed]

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