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Chemical Compound Review:

Guanoxan 2-(7,10- dioxabicyclo[4.4.0]deca- 1,3,5...

Synonyms: Guanoxon, Envacar, Guanoxane, Guanoxano, Guanoxanum, ...

Vigne, P. et al., Joshi, M. et al., Arglebe, C. et al., Otton, S.V. et al.

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High impact information on Envacar

Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes [1].
These binding sites may be the normal target of a series of imidazolidines derivatives (guanabenz, guanochlor, guanoxan), which are known for their antihypertensive properties [1].
The results of such in vitro testing implicated the involvement of guanoxan, nortriptyline, desipramine, imipramine, amitriptyline and chlorpromazine with this enzyme [2].
Studies on the sympathomimetic effects of guanoxan on smooth muscles of rat [3].
In anococcygeus muscle and vas deferens preparations of rat, guanidinomethyl-2-benzo-(1,4)-dioxane (guanoxan) potentiated responses to norepinephrine (NF) in concentrations which exerted a neurone blocking effect [3].

Anatomical context of Envacar

The influence of guanoxane on the submaxillary glands of rats. Another model of neurogenic sialoses [4].

Associations of Envacar with other chemical compounds

In extracts of submaxillary glands of rats, treated with the guanethidine derivative, guanoxane (Envacar), alpha-amylase activity and protein concentration were measured [4].

References

Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes. Vigne, P., Lazdunski, M., Frelin, C. Eur. J. Pharmacol. (1989) [Pubmed]
Inhibition of sparteine oxidation in human liver by tricyclic antidepressants and other drugs. Otton, S.V., Inaba, T., Kalow, W. Life Sci. (1983) [Pubmed]
Studies on the sympathomimetic effects of guanoxan on smooth muscles of rat. Joshi, M., Joshi, N.J., Shah, D.S., Hemavathi, K.G., Gulati, O.D. Arzneimittel-Forschung. (1978) [Pubmed]
The influence of guanoxane on the submaxillary glands of rats. Another model of neurogenic sialoses. Arglebe, C., Krause, A., Chilla, R. Acta Otolaryngol. (1976) [Pubmed]

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