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Chemical Compound Review

Hypnadh     [[(2R,3S,4R,5R)-5-(3- aminocarbonyl-4H...

Synonyms: Deamino-NADH, KST-1A7340, AR-1A8558, AC1L511N, 22052-73-9, ...
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Disease relevance of Deamino-NADH

  • The reconstituted complex I from Klebsiella pneumoniae catalyzed deamino-NADH oxidation, Q1 reduction, and Na(+) translocation with specific activities of 2.6 units mg(-1), 2.4 units mg(-1), and 4.7 units mg(-1), respectively, which indicate a Na(+)/electron stoichiometry of one [1].
  • Inside-out membrane vesicles from E. coli GR19N generate a H+ electrochemical gradient (interior positive and acid) during electron transfer from deamino-NADH to ubiquinone 1 that is large and stable relative to that observed with NADH as substrate [2].
  • Membrane vesicles prepared from Zymomonas mobilis oxidized NADH exclusively, whereas deamino-NADH was little oxidized [3].
  • Membranes prepared from Bacillus cereus KCTC 3674, grown aerobically on a complex medium, oxidized NADH exclusively, whereas deamino-NADH was little oxidized [4].
  • Membranes of Pseudomonas nautica, grown aerobically on a complex medium, oxidized both NADH and deamino-NADH as substrates [5].

High impact information on Deamino-NADH


  1. The respiratory complex I (NDH I) from Klebsiella pneumoniae, a sodium pump. Gemperli, A.C., Dimroth, P., Steuber, J. J. Biol. Chem. (2002) [Pubmed]
  2. NADH-ubiquinone oxidoreductases of the Escherichia coli aerobic respiratory chain. Matsushita, K., Ohnishi, T., Kaback, H.R. Biochemistry (1987) [Pubmed]
  3. A novel aerobic respiratory chain-linked NADH oxidase system in Zymomonas mobilis. Kim, Y.J., Song, K.B., Rhee, S.K. J. Bacteriol. (1995) [Pubmed]
  4. Enzymatic properties of the membrane-bound NADH oxidase system in the aerobic respiratory chain of Bacillus cereus. Kim, M.S., Kim, Y.J. J. Biochem. Mol. Biol. (2004) [Pubmed]
  5. Enzymatic and energetic properties of the aerobic respiratory chain-linked NADH oxidase system in the marine bacterium Pseudomonas nautica. Cho, K.H., Kim, Y.J. Mol. Cells (2000) [Pubmed]
  6. Expression and characterization of the flavoprotein subcomplex composed of 50-kDa (NQO1) and 25-kDa (NQO2) subunits of the proton-translocating NADH-quinone oxidoreductase of Paracoccus denitrificans. Yano, T., Sled', V.D., Ohnishi, T., Yagi, T. J. Biol. Chem. (1996) [Pubmed]
  7. Mutagenesis of subunit N of the Escherichia coli complex I. Identification of the initiation codon and the sensitivity of mutants to decylubiquinone. Amarneh, B., Vik, S.B. Biochemistry (2003) [Pubmed]
  8. Purification of the 45 kDa, membrane bound NADH dehydrogenase of Escherichia coli (NDH-2) and analysis of its interaction with ubiquinone analogues. Björklöf, K., Zickermann, V., Finel, M. FEBS Lett. (2000) [Pubmed]
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