Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL87568 1,4,5,8-tetraaminoanthracene- 9,10-dione

Synonyms: SureCN125495, CCRIS 1419, NCI-C54900, AG-E-74290, Acetate Blue 6, ...

Haws, L.C. et al., Harrington-Brock, K. et al., Yourick, J.J. et al.

Yourick, Koenig, Yourick, Bronaugh,

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Disease relevance of Cilla Blue Extra

Dietary administration of Disperse Blue 1 in a National Toxicology Program (NTP) carcinogenesis bioassay produced transitional- and squamous-cell tumors, leiomyomas, and leiomyosarcomas of the urinary bladders of male and female F344/N rats [1].

High impact information on Cilla Blue Extra

The present study investigated the fate of three chemicals [dihydroxyacetone (DHA), 7-(2H-naphtho[1,2-d]triazol-2-yl)-3-phenylcoumarin (7NTPC), and disperse blue 1 (DB1)] in an in vitro absorption study [2].
Disperse Blue 1 is an anthraquinone dye used at low levels in semipermanent hair color formulations [1].
Compounds which were not evaluated either with or without S9 activation because of their insolubility in the culture medium include 1-amino-2,4-dibromoanthraquinone, D&C Green, Disperse Blue 1, Disperse Red 60, Vat Blue 4, Vat Blue 20, Vat Brown 1 and Vat Brown 3 [3].

References

Two approaches for assessing human safety of disperse blue 1. Haws, L.C., Jackson, B.A., Turnbull, D., Dressler, W.E. Regulatory toxicology and pharmacology : RTP. (1994) [Pubmed]
Fate of chemicals in skin after dermal application: does the in vitro skin reservoir affect the estimate of systemic absorption? Yourick, J.J., Koenig, M.L., Yourick, D.L., Bronaugh, R.L. Toxicol. Appl. Pharmacol. (2004) [Pubmed]
Analysis of the genotoxicity of anthraquinone dyes in the mouse lymphoma assay. Harrington-Brock, K., Parker, L., Doerr, C., Cimino, M.C., Moore, M.M. Mutagenesis (1991) [Pubmed]

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