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MeSH Review

Dilatation and Curettage

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Disease relevance of Dilatation and Curettage


High impact information on Dilatation and Curettage

  • Lipsticks containing D&C Orange No. 17 and those labeled with the words "may contain" D&C Orange No. 17 should be suspected of being mutagenic for S. typhimurium TA98 [6].
  • Drug and Cosmetic (D&C) Orange No. 17, a monoazo dye with two nitro groups, was highly mutagenic in the absence of S-9 [6].
  • Significantly fewer anastrozole patients required a repeat hysteroscopy and D&C compared with those on tamoxifen [4 of 83 (4.8%) and 29 of 88 (33.0%), respectively; P < 0.0001] [7].
  • The D&C controls had a higher frequency of estrogen use than either of the other control groups or the cases [8].
  • The present work describes (a) the identification and characterization of an impurity, 2,4,5,7-tetrabromo-6-hydroxy-9-(2,3,4,5-tetrachlorophenyl)-3H-xanthen-3-one (BCPX), in the color additives D&C Red Nos. 27 and 28 (phloxine B) and (b) the determination of the extent and level of BCPX contamination in certified lots of these colors [9].

Chemical compound and disease context of Dilatation and Curettage


Biological context of Dilatation and Curettage


Anatomical context of Dilatation and Curettage


Associations of Dilatation and Curettage with chemical compounds

  • Two containing D&C Orange No. 17 were directly mutagenic [6].
  • A centrifugal counter-current chromatographic method for preparative purification of commercial tetrabromotetrachlorofluorescein and Phloxine B (D&C Red Nos. 27 and 28, respectively) was developed [14].
  • One participant in the misoprostol group had an emergency D&C for heavy bleeding [15].
  • Sixty patients who presented for day-case dilatation and curettage were allocated randomly to receive either thiopentone or propofol for induction and maintenance of anaesthesia [16].
  • CONCLUSION: Low-dose droperidol 0.625 mg i.v. for anti-emetic prophylaxis can cause balance disturbances in females after gynaecological dilatation and curettage procedures [17].

Gene context of Dilatation and Curettage

  • In 68 patients undergoing voluntary abortion, prolactin levels were measured to study the effect of anesthetics and of dilatation and curettage on hormonal secretion [18].
  • Analysis of these women's obstetric history revealed that those at risk for pregnancy in a Caesarean scar appear to have a history of dilatation and curettage, placental pathology, ectopic pregnancy, and IVF [19].
  • BACKGROUND: Dilatation and curettage (D&C) has been the usual treatment for early pregnancy failure (EPF) [20].
  • If the latter group is excluded, the Mi Mark procedure could replace D&C in 47% of cases [21].
  • In this review, four patients with pseudogestational sacs had internal echoes within the sac, and two of them ultimately underwent dilatation and curettage, which revealed blood clots [22].

Analytical, diagnostic and therapeutic context of Dilatation and Curettage


  1. Presumed diagnosis of ectopic pregnancy. Barnhart, K.T., Katz, I., Hummel, A., Gracia, C.R. Obstetrics and gynecology. (2002) [Pubmed]
  2. Development of metastatic endometrial endometrioid adenocarcinoma while on progestin therapy for endometrial hyperplasia. Rubatt, J.M., Slomovitz, B.M., Burke, T.W., Broaddus, R.R. Gynecol. Oncol. (2005) [Pubmed]
  3. Lidocaine pretreatment effectively decreases the incidence of hiccups during methohexitone administration for dilatation and curettage. Weksler, N., Stav, A., Ovadia, L., Berman, M., Segal, A., Ribac, L., Lemberg, L. Acta anaesthesiologica Scandinavica. (1992) [Pubmed]
  4. Evaluation of hypersensitivity to anthraquinone-related substances. Fujii, S. Toxicology (2003) [Pubmed]
  5. Dexamethasone alone does not prevent postoperative nausea and vomiting in women undergoing dilatation and curettage: a comparison with droperidol and saline. Tzeng, J.I., Tswei, T.S., Tang, C.S., Ho, S.T., Wang, J.J. Acta Anaesthesiol. Sin. (2000) [Pubmed]
  6. Mutagenicity of some lipsticks and their dyes. Green, M.R., Pastewka, J.V. J. Natl. Cancer Inst. (1980) [Pubmed]
  7. Anastrozole versus tamoxifen treatment in postmenopausal women with endocrine-responsive breast cancer and tamoxifen-induced endometrial pathology. Gerber, B., Krause, A., Reimer, T., Mylonas, I., Makovitzky, J., Kundt, G., Janni, W. Clin. Cancer Res. (2006) [Pubmed]
  8. "Alternative" controls in a case-control study of endometrial cancer and exogenous estrogen. Hulka, B.S., Grimson, R.C., Greenberg, B.G., Kaufman, D.G., Fowler, W.C., Hogue, C.J., Berger, G.S., Pulliam, C.C. Am. J. Epidemiol. (1980) [Pubmed]
  9. Identification of the decarboxylated analog of tetrabromotetrachloro-fluorescein and its quantification in the color additives D&C Red Nos. 27 and 28 (phloxine B) using high-performance liquid chromatography. Weisz, A., Wright, P.R., Andrzejewski, D., Meyers, M.B., Glaze, K., Mazzola, E.J. Journal of chromatography. A. (2006) [Pubmed]
  10. Four-week oral toxicity study of 1-carboxy-5,7-dibromo-6-hydroxy-2,3,4-trichloroxanthone (HXCA), an impurity of Phloxine B, in F344 rats. Hagiwara, A., Sano, M., Ichihara, T., Yoshino, H., Miyata, E., Tamano, S., Aoki, H., Yukawa, C., Koda, T., Nakamura, M., Shirai, T. The Journal of toxicological sciences. (2003) [Pubmed]
  11. A randomized trial comparing oral misoprostol with intra-amniotic prostaglandin F2alpha for second trimester terminations. Marquette, G.P., Skoll, M.A., Dontigny, L. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC. (2005) [Pubmed]
  12. Cervical conization: when is uterine dilatation and curettage also indicated? Helmkamp, B.F., Denslow, B.L., Bonfiglio, T.A., Beecham, J.B. Am. J. Obstet. Gynecol. (1983) [Pubmed]
  13. Bolus application of remifentanil with propofol for dilatation and curettage. Castillo, T., Avellanal, M., Garcia de Lucas, E. European journal of anaesthesiology. (2004) [Pubmed]
  14. Preparative purification of tetrabromotetrachlorofluorescein and phloxine B by centrifugal counter-current chromatography. Weisz, A., Langowski, A.J., Meyers, M.B., Thieken, M.A., Ito, Y. J. Chromatogr. (1991) [Pubmed]
  15. Medical management of missed abortion: a randomized clinical trial. Wood, S.L., Brain, P.H. Obstetrics and gynecology. (2002) [Pubmed]
  16. Recovery after day-case anaesthesia. A 24-hour comparison of recovery after thiopentone or propofol anaesthesia. Heath, P.J., Ogg, T.W., Gilks, W.R. Anaesthesia. (1990) [Pubmed]
  17. Evaluation of postural stability after low-dose droperidol in outpatients undergoing gynaecological dilatation and curettage procedure. Song, D., Chung, F., Yogendran, S., Wong, J. British journal of anaesthesia. (2002) [Pubmed]
  18. Prolactin and certain obstetric stress conditions. Volpe, A., Mazza, V., Di Renzo, G.C. International journal of biological research in pregnancy. (1982) [Pubmed]
  19. Ectopic pregnancies in a Caesarean scar: review of the medical approach to an iatrogenic complication. Maymon, R., Halperin, R., Mendlovic, S., Schneider, D., Herman, A. Hum. Reprod. Update (2004) [Pubmed]
  20. Bleeding patterns after vaginal misoprostol for treatment of early pregnancy failure. Davis, A.R., Robilotto, C.M., Westhoff, C.L., Forman, S., Zhang, J. Hum. Reprod. (2004) [Pubmed]
  21. Endometrial sampling using the Mi Mark procedure as a primary routine: first year's experience. Uvebrant, M., Bergström, H., Hansson, G., Mattsson, L.A. Maturitas. (1989) [Pubmed]
  22. The echoic pseudogestational sac of ectopic pregnancy simulating early intrauterine pregnancy. Schaffer, R.M., Stein, K., Shih, Y.H., Goodman, J.D. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. (1983) [Pubmed]
  23. Ondansetron in the treatment of postoperative vomiting: a randomized, double-blind comparison with droperidol and metoclopramide. Alon, E., Himmelseher, S. Anesth. Analg. (1992) [Pubmed]
  24. Effect of different kinds of premedication on the induction properties of midazolam. Kanto, J., Sjövall, S., Vuori, A. British journal of anaesthesia. (1982) [Pubmed]
  25. Double blind comparison of alfentanil N2O and fentanyl N2O for outpatient surgical procedures. Enright, A.B., Parker, J.B. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1988) [Pubmed]
  26. Ultrasound evaluation of ectopic pregnancy. Laing, F.C., Jeffrey, R.B. Radiol. Clin. North Am. (1982) [Pubmed]
  27. Liquid chromatographic determination of 2,4-dinitroaniline and 2-naphthol in D&C Orange No. 17. Scher, A.L. Journal - Association of Official Analytical Chemists. (1985) [Pubmed]
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