Disease relevance of Dilatation and Curettage

• A D&C is necessary to differentiate an ectopic pregnancy from a miscarriage before a woman is presumptively treated with methotrexate [1].
• CASE: A 40-year-old woman with endometrial complex atypical hyperplasia diagnosed by dilatation and curettage was managed conservatively with progestin therapy (initially, megesterol acetate; then, a combination oral contraceptive) [2].
• The efficacy of lidocaine 1 mg.kg-1 for prevention of methohexitone-induced hiccups was assessed in a double-blind fashion in 200 patients undergoing dilatation and curettage for pregnancy interruption [3].
• In animals sensitized with 1% commercial-grade D&C Green No. 6 (Quinizarin Green SS, CI61565), subsequent challenge with the same dye showed a dose-dependent hypersensitivity reaction, whereas challenge with D&C Green No. 6 purified by recrystallization did not [4].
• CONCLUSIONS: We conclude that dexamethasone (8 mg) alone does not prevent PONV in women undergoing dilatation and curettage [5].

High impact information on Dilatation and Curettage

• Lipsticks containing D&C Orange No. 17 and those labeled with the words "may contain" D&C Orange No. 17 should be suspected of being mutagenic for S. typhimurium TA98 [6].
• Drug and Cosmetic (D&C) Orange No. 17, a monoazo dye with two nitro groups, was highly mutagenic in the absence of S-9 [6].
• Significantly fewer anastrozole patients required a repeat hysteroscopy and D&C compared with those on tamoxifen [4 of 83 (4.8%) and 29 of 88 (33.0%), respectively; P < 0.0001] [7].
• The D&C controls had a higher frequency of estrogen use than either of the other control groups or the cases [8].
• The present work describes (a) the identification and characterization of an impurity, 2,4,5,7-tetrabromo-6-hydroxy-9-(2,3,4,5-tetrachlorophenyl)-3H-xanthen-3-one (BCPX), in the color additives D&C Red Nos. 27 and 28 (phloxine B) and (b) the determination of the extent and level of BCPX contamination in certified lots of these colors [9].

Chemical compound and disease context of Dilatation and Curettage

• This study was designed to evaluate and characterize any subacute toxicity of 1-carboxy-5,7-dibromo-6-hydroxy-2,3,4-trichloroxanthone (HXCA), an impurity of Phloxine B (Food Red No. 104 in Japan, D&C Red No. 28 in the USA), when administered to both sexes of F344 rats at dietary levels of 0 (control), 0.005, 0.05 and 0.5% [10].
• Dexamethasone alone does not prevent postoperative nausea and vomiting in women undergoing dilatation and curettage: a comparison with droperidol and saline [5].
• The rate of retained placenta requiring D&C was significantly greater in the PGF2alpha group (22.4% vs. 3.4%, P = 0.002) [11].

Biological context of Dilatation and Curettage

• We believe more precise criteria for combining dilatation and curettage with conization are required, and these include: patients in the peri- or postmenopausal period, suspected intrauterine abnormalities, and the presence of abnormal glandular cells in a cytologic sample [12].

Anatomical context of Dilatation and Curettage

• BACKGROUND AND OBJECTIVE: This study was designed to determine which single bolus dose of remifentanil in combination with propofol and nitrous oxide is best to control the haemodynamic, autonomous and somatic responses in patients scheduled for dilatation and curettage of the uterine cervix [13].

Associations of Dilatation and Curettage with chemical compounds

• Two containing D&C Orange No. 17 were directly mutagenic [6].
• A centrifugal counter-current chromatographic method for preparative purification of commercial tetrabromotetrachlorofluorescein and Phloxine B (D&C Red Nos. 27 and 28, respectively) was developed [14].
• One participant in the misoprostol group had an emergency D&C for heavy bleeding [15].
• Sixty patients who presented for day-case dilatation and curettage were allocated randomly to receive either thiopentone or propofol for induction and maintenance of anaesthesia [16].
• CONCLUSION: Low-dose droperidol 0.625 mg i.v. for anti-emetic prophylaxis can cause balance disturbances in females after gynaecological dilatation and curettage procedures [17].

Gene context of Dilatation and Curettage

• In 68 patients undergoing voluntary abortion, prolactin levels were measured to study the effect of anesthetics and of dilatation and curettage on hormonal secretion [18].
• Analysis of these women's obstetric history revealed that those at risk for pregnancy in a Caesarean scar appear to have a history of dilatation and curettage, placental pathology, ectopic pregnancy, and IVF [19].
• BACKGROUND: Dilatation and curettage (D&C) has been the usual treatment for early pregnancy failure (EPF) [20].
• If the latter group is excluded, the Mi Mark procedure could replace D&C in 47% of cases [21].
• In this review, four patients with pseudogestational sacs had internal echoes within the sac, and two of them ultimately underwent dilatation and curettage, which revealed blood clots [22].

Analytical, diagnostic and therapeutic context of Dilatation and Curettage

• We conclude that preoperative prophylactic administration of ondansetron is superior to droperidol or metoclopramide in the prevention of emetic sequelae after general anesthesia for dilatation and curettage [23].
• The effects of different premedication (i.m. and i.v.) on the usefulness of midazolam or thiopentone as induction agents for minor surgery was studied in 194 women undergoing either dilatation and curettage or explorative fractionate curettage [24].
• Alfentanil - nitrous oxide and fentanyl - nitrous oxide techniques were compared in outpatients undergoing therapeutic abortion or dilatation and curettage [25].
• Subsequent evaluation in suspicious cases may require a variety of tests including serial HCG determinations, repeat ultrasound examination, uterine dilatation and curettage, culdocentesis, or laparoscopy [26].
• A method is described for the determination of the intermediates in D&C Orange No. 17 by reverse phase liquid chromatography [27].

References