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Chemical Compound Review:

Tropeolin thiocyanatomethylbenzene

Synonyms: Benzylrhodonid, Solvat 14, CPD-65, NSC-1729, ACMC-1CPDD, ...

Reddy, B.S. et al., Fiala, E.S. et al., Nayini, J.R. et al., Lee, T.P. et al.

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Disease relevance of thiocyanatomethylbenzene

The body weight gains of rats fed the 25- and 50-ppm BSC-containing diets for 3 weeks were less (27 and 43%, respectively) than those of rats fed either the control or BTC-containing diets [1].

High impact information on thiocyanatomethylbenzene

While liver microsomes from rats fed the BTC diets metabolized AOM and MAM at rates not significantly different from those obtained with control liver microsomes, the metabolic activation of AOM as well as of MAM was stimulated severalfold when assayed with liver microsomes from rats fed the BSC diets [1].
The effect of feeding benzylselenocyanate (BSC) and its sulfur analogue, benzylthiocyanate (BTC), 2 wk before, during, and until 1 wk after carcinogen administration (initiation phase) on intestinal carcinogenesis induced by azoxymethane (CAS:25843-45-2) was studied in male F344 rats [2].
Tissue and blood plasma glutathione peroxidase activity was measured in vehicle-treated animals fed the control diet and BSC and BTC diets for 5 wk [2].
Selenium-dependent glutathione peroxidase activity was significantly increased in kidneys and colon and small intestinal mucosae of animals fed the BSC diet compared to animals fed the BTC and control diets [2].
The effect of dietary benzylselenocyanate (BSC) and its analogue, benzylthiocyanate (BTC), and sodium selenite during the initiation and postinitiation phases of azoxymethane (AOM)-induced intestinal carcinogenesis was studied in male F344 rats [3].

Anatomical context of thiocyanatomethylbenzene

Higher degrees of inhibition were observed if the lymphocytes were pretreated with pesticides in the absence of serum: pp-DDT inhibited by 73% trithion by 50% and benzylthiocyanate by 30% [4].

References

Mechanism of benzylselenocyanate inhibition of azoxymethane-induced colon carcinogenesis in F344 rats. Fiala, E.S., Joseph, C., Sohn, O.S., el-Bayoumy, K., Reddy, B.S. Cancer Res. (1991) [Pubmed]
Chemoprevention of colon carcinogenesis by dietary organoselenium, benzylselenocyanate, in F344 rats. Reddy, B.S., Sugie, S., Maruyama, H., el-Bayoumy, K., Marra, P. Cancer Res. (1987) [Pubmed]
Effect of dietary benzylselenocyanate on azoxymethane-induced colon carcinogenesis in male F344 rats. Nayini, J.R., Sugie, S., el-Bayoumy, K., Rao, C.V., Rigotty, J., Sohn, O.S., Reddy, B.S. Nutrition and cancer. (1991) [Pubmed]
Effects of pesticides on human leukocyte functions. Lee, T.P., Moscati, R., Park, B.H. Res. Commun. Chem. Pathol. Pharmacol. (1979) [Pubmed]

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