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Chemical Compound Review

SELENIOUS ACID     selenous acid

Synonyms: Selenous acid, CCRIS 5530, NCIMech_000026, AG-H-11803, AG-L-18585, ...
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Disease relevance of SODIUM SELENITE


Psychiatry related information on SODIUM SELENITE


High impact information on SODIUM SELENITE


Chemical compound and disease context of SODIUM SELENITE


Biological context of SODIUM SELENITE


Anatomical context of SODIUM SELENITE

  • This hypothesis was indirectly supported by tissue selenium measurements showing that 0.5 or 0.25% of vitamin C in the diet completely negated in blood, liver, and mammary gland the accumulation of selenium induced by 3 ppm of selenite supplementation [22].
  • We found that the addition of sodium selenite and sodium selenate inhibited the growth of human 3B6 and BL41 lymphocytes [23].
  • After chronic exposure to selenite, cells showed growth inhibition caused by cell cycle arrest, increased numbers of mitochondria and levels of mitochondrial enzymes, and only minimal induction of apoptosis [21].
  • Brief pre-exposure of HeLa cells to micromolar concentrations of selenite resulted in a dose-dependent decrease in the rate of their subsequent attachment to a solid matrix (tissue culture dish) [24].
  • LNCaP cells treated with selenite also showed p53 translocation to mitochondria, cytochrome c release into the cytosol, and activation of caspase-9 [25].

Associations of SODIUM SELENITE with other chemical compounds


Gene context of SODIUM SELENITE


Analytical, diagnostic and therapeutic context of SODIUM SELENITE


  1. Oxidation of elemental selenium to selenite by Bacillus megaterium. Sarathchandra, S.U., Watkinson, J.H. Science (1981) [Pubmed]
  2. Phase-separation inhibitors and prevention of selenite cataract. Clark, J.I., Steele, J.E. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Direct detection of potential selenium delivery proteins by using an Escherichia coli strain unable to incorporate selenium from selenite into proteins. Lacourciere, G.M., Levine, R.L., Stadtman, T.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Inhibition of NF-kappaB DNA binding and nitric oxide induction in human T cells and lung adenocarcinoma cells by selenite treatment. Kim, I.Y., Stadtman, T.C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  5. Influence of intracellular glutathione on selenite-mediated growth inhibition of canine mammary tumor cells. Kuchan, M.J., Milner, J.A. Cancer Res. (1992) [Pubmed]
  6. Transient hypothermia and hyperphagia induced by selenium and tellurium compounds in mice. Watanabe, C., Suzuki, T., Ohba, T., Dejima, Y. Toxicol. Lett. (1990) [Pubmed]
  7. Selenium-induced alteration of lipids, lipid peroxidation, and thiol group in circadian rhythm centers of rat. Islam, F., Zia, S., Sayeed, I., Zafar, K.S., Ahmad, A.S. Biological trace element research. (2002) [Pubmed]
  8. Neuroprotective effect of antioxidants on ischaemia and reperfusion-induced cerebral injury. Gupta, R., Singh, M., Sharma, A. Pharmacol. Res. (2003) [Pubmed]
  9. Radioprotection by metals: selenium. Weiss, J.F., Srinivasan, V., Kumar, K.S., Landauer, M.R. Advances in space research : the official journal of the Committee on Space Research (COSPAR). (1992) [Pubmed]
  10. Partial replacement of serum by selenite, transferrin, albumin and lecithin in haemopoietic cell cultures. Guilbert, L.J., Iscove, N.N. Nature (1976) [Pubmed]
  11. New approaches to cancer chemoprevention with difluoromethylornithine and selenite. Ip, C., Thompson, H.J. J. Natl. Cancer Inst. (1989) [Pubmed]
  12. Properties of mouse mammary epithelial cell lines characterized by in vivo transplantation and in vitro immunocytochemical methods. Medina, D., Oborn, C.J., Kittrell, F.S., Ullrich, R.L. J. Natl. Cancer Inst. (1986) [Pubmed]
  13. Decreased antioxidant defence and increased oxidant stress during dexamethasone-induced apoptosis: bcl-2 prevents the loss of antioxidant enzyme activity. Baker, A.F., Briehl, M.M., Dorr, R., Powis, G. Cell Death Differ. (1996) [Pubmed]
  14. Similarities between the abiotic reduction of selenite with glutathione and the dissimilatory reaction mediated by Rhodospirillum rubrum and Escherichia coli. Kessi, J., Hanselmann, K.W. J. Biol. Chem. (2004) [Pubmed]
  15. Extracellular Production of Hydrogen Selenide Accounts for Thiol-assisted Toxicity of Selenite against Saccharomyces cerevisiae. Tarze, A., Dauplais, M., Grigoras, I., Lazard, M., Ha-Duong, N.T., Barbier, F., Blanquet, S., Plateau, P. J. Biol. Chem. (2007) [Pubmed]
  16. Selenite induces apoptosis in sarcomatoid malignant mesothelioma cells through oxidative stress. Nilsonne, G., Sun, X., Nyström, C., Rundlöf, A.K., Potamitou Fernandes, A., Björnstedt, M., Dobra, K. Free Radic. Biol. Med. (2006) [Pubmed]
  17. Redox modulation of human prostate carcinoma cells by selenite increases radiation-induced cell killing. Husbeck, B., Peehl, D.M., Knox, S.J. Free Radic. Biol. Med. (2005) [Pubmed]
  18. Effects of antioxidants on oxidant-induced sister chromatid exchange formation. Weitberg, A.B., Weitzman, S.A., Clark, E.P., Stossel, T.P. J. Clin. Invest. (1985) [Pubmed]
  19. Inhibition of AP-1 binding and transcription by gold and selenium involving conserved cysteine residues in Jun and Fos. Handel, M.L., Watts, C.K., deFazio, A., Day, R.O., Sutherland, R.L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  20. Methanococcus vannielii selenium-binding protein (SeBP): chemical reactivity of recombinant SeBP produced in Escherichia coli. Patteson, K.G., Trivedi, N., Stadtman, T.C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  21. Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line. Zhong, W., Oberley, T.D. Cancer Res. (2001) [Pubmed]
  22. Interaction of vitamin C and selenium supplementation in the modification of mammary carcinogenesis in rats. Ip, C. J. Natl. Cancer Inst. (1986) [Pubmed]
  23. Selenite and selenate inhibit human lymphocyte growth via different mechanisms. Spyrou, G., Björnstedt, M., Skog, S., Holmgren, A. Cancer Res. (1996) [Pubmed]
  24. Inhibition of cell attachment by selenite. Yan, L., Frenkel, G.D. Cancer Res. (1992) [Pubmed]
  25. Expression of p53 enhances selenite-induced superoxide production and apoptosis in human prostate cancer cells. Zhao, R., Xiang, N., Domann, F.E., Zhong, W. Cancer Res. (2006) [Pubmed]
  26. Formation of a selenium-substituted rhodanese by reaction with selenite and glutathione: possible role of a protein perselenide in a selenium delivery system. Ogasawara, Y., Lacourciere, G., Stadtman, T.C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  27. Effect of an inorganic and organic form of dietary selenium on the promotional stage of mammary carcinogenesis in the rat. Thompson, H.J., Meeker, L.D., Kokoska, S. Cancer Res. (1984) [Pubmed]
  28. Enhanced sensitivity of human oral carcinomas to induction of apoptosis by selenium compounds: involvement of mitogen-activated protein kinase and Fas pathways. Ghose, A., Fleming, J., El-Bayoumy, K., Harrison, P.R. Cancer Res. (2001) [Pubmed]
  29. Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation. Tamura, T., Yamamoto, S., Takahata, M., Sakaguchi, H., Tanaka, H., Stadtman, T.C., Inagaki, K. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  30. Mechanisms of the regulation of thioredoxin reductase activity in cancer cells by the chemopreventive agent selenium. Gallegos, A., Berggren, M., Gasdaska, J.R., Powis, G. Cancer Res. (1997) [Pubmed]
  31. Selenite inhibits the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) through a thiol redox mechanism. Park, H.S., Park, E., Kim, M.S., Ahn, K., Kim, I.Y., Choi, E.J. J. Biol. Chem. (2000) [Pubmed]
  32. Low affinity orthophosphate carriers regulate PHO gene expression independently of internal orthophosphate concentration in Saccharomyces cerevisiae. Pinson, B., Merle, M., Franconi, J.M., Daignan-Fornier, B. J. Biol. Chem. (2004) [Pubmed]
  33. Utilizing selenious acid to reverse selenium deficiency in total parenteral nutrition patients. Baptista, R.J., Bistrian, B.R., Blackburn, G.L., Miller, D.G., Champagne, C.D., Buchanan, L. Am. J. Clin. Nutr. (1984) [Pubmed]
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