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Chemical Compound Review

PubChem9845     7,8-dihydroxy-2-phenyl- chromen-4-one

Synonyms: SPECTRUM201315, CHEMBL75267, SureCN419316, ACMC-1AFU3, AG-F-34505, ...
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High impact information on FLAVONE

  • Applying this method to determine the inhibitory effects of reported in vitro NQO1 inhibitors (dicoumarol, 7,8-dihydroxyflavone, chrysin) showed that for all inhibitors tested, the IC50 in intact cells was at least 3 orders of magnitude higher than the IC50 in cell lysates [1].
  • Overall, the best in vitro trypanocidal activity for T. brucei rhodesiense was exerted by 7,8-dihydroxyflavone (50% inhibitory concentration [IC(50)], 68 ng/ml), followed by 3-hydroxyflavone, rhamnetin, and 7,8,3',4'-tetrahydroxyflavone (IC(50)s, 0.5 mug/ml) and catechol (IC(50), 0.8 mug/ml) [2].
  • Possible tumor-promoting activity of four flavonoids, quercetin (QC), tangeretin (TG), flavone (FO), and flavanone (FN), was examined in a rat liver short-term carcinogenesis assay as well as with in vivo and in vitro assays of inhibition of gap junctional intercellular communication (GJIC) [3].
  • Conversely, protective properties were seen for some of the compounds in antipromotion in vitro studies, because TG and FN enhanced the dye transfer in REL cells and FO, TG, and QC partly prevented the inhibition of metabolic cooperation by 12-O-tetradecanoylphorbol-13-acetate [3].
  • In cell cycle analysis, all the flavonoids tested, except F01 and F04, reduced the G0/G1 population of SF295 cells at growth inhibitory concentrations, and increased G2/M (F02, F03 and F06) or S (F05 and F07) populations [4].

Associations of FLAVONE with other chemical compounds


  1. Human NAD(P)H:quinone oxidoreductase inhibition by flavonoids in living cells. Lee, Y.Y., Westphal, A.H., de Haan, L.H., Aarts, J.M., Rietjens, I.M., van Berkel, W.J. Free Radic. Biol. Med. (2005) [Pubmed]
  2. Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. Tasdemir, D., Kaiser, M., Brun, R., Yardley, V., Schmidt, T.J., Tosun, F., Rüedi, P. Antimicrob. Agents Chemother. (2006) [Pubmed]
  3. Lack of tumor-promoting effects of flavonoids: studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication. Chaumontet, C., Suschetet, M., Honikman-Leban, E., Krutovskikh, V.A., Berges, R., Le Bon, A.M., Heberden, C., Shahin, M.M., Yamasaki, H., Martel, P. Nutrition and cancer. (1996) [Pubmed]
  4. Effects of flavonoids on the growth and cell cycle of cancer cells. Choi, S.U., Ryu, S.Y., Yoon, S.K., Jung, N.P., Park, S.H., Kim, K.H., Choi, E.J., Lee, C.O. Anticancer Res. (1999) [Pubmed]
  5. Inhibition of mitochondrial respiration and cyanide-stimulated generation of reactive oxygen species by selected flavonoids. Hodnick, W.F., Duval, D.L., Pardini, R.S. Biochem. Pharmacol. (1994) [Pubmed]
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