Disease relevance of Rhamnetin

• This clone (pBFST3) was expressed in Escherichia coli and produced an F3-ST with high affinity for the flavonol aglycones, quercetin, and its 7-methyl derivative, rhamnetin [1].

High impact information on Rhamnetin

• Quercetin, rhamnetin, isohamnetin, apigenin and luteolin were isolated from medicinal herbs: Erigeron canadensis L., Anthyllis vulneraria L. and Pyrola chloranta L [2].
• Results show that a high concentration of phenolic coumarins and the presence of quercetin and rhamnetin in the exudates could account for the protection of the plant against oxidative stress [3].
• The enzyme inhibition was also indicated in the cultured Caco-2 cells by the significantly reduced conversion of beta-carotene to retinol when incubated with BHT and rhamnetin at 2 microM and 5 microM, respectively [4].
• From the berries of Rhamnus petiolaris a new acylated flavonol glycoside was isolated and identified as rhamnetin 3-O-[3""-O-(p-coumaroyl)-alpha-L-rhamnopyranosyl(1-->3)- alpha-L-rhamnopyranosyl(1-->6)]-beta-D-galactopyranoside [5].
• In another assay only rhamnetin inhibited peroxidation of phospholipid liposomes (IC50 = 2.4 microM) [6].

Chemical compound and disease context of Rhamnetin

• The alkylation of bacterial DNA by two flavonoids: rhamnetin and isorhamnetin was examined using of strains Escherichia coli K-12: AB1157 (ada+) and (ada3) [7].

Associations of Rhamnetin with other chemical compounds

• The mutagenic compounds were purified, and 2 flavonols, quercetin and rhamnetin, were identified as the major mutagens in the pickles by gas chromatography-mass spectrometry [8].

Analytical, diagnostic and therapeutic context of Rhamnetin

• Two compounds were isolated by preparative HPLC, and their structures were elucidated on the basis of ESI-MS as well as NMR spectroscopy, establishing the two compounds as rhamnetin 3-O-beta-galactopyranoside and rhamnetin 3-O-beta-glucopyranoside, respectively [9].

References