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Chemical Compound Review

Baicelein     5,6,7-trihydroxy-2-phenyl- chromen-4-one

Synonyms: Biacalein, Noroxylin, baicalein, Sho-saiko-to, Tocris-1761, ...
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Disease relevance of C10023


Psychiatry related information on C10023


High impact information on C10023


Chemical compound and disease context of C10023

  • Collectively, these data suggest contribution of PGI2 to the acute antihypertensive effect of baicalein in rats with angiotensin II-induced hypertension [11].
  • Herbal medicine Sho-saiko-to (TJ-9) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet [12].
  • To evaluate the protective effects of baicalein and wogonin against benzo[a]pyrene- and aflatoxin (AF) B(1)-induced toxicities, the effects of these flavonoids on the genotoxicities and oxidation of benzo[a]pyrene and AFB(1) were studied in C57BL/6J mice [13].
  • To further this work, we studied the antioxidative effects of baicalein, a flavonoid component of S. baicalensis, in a chick cardiomyocyte model of reactive oxygen species (ROS) generation during hypoxia, simulated ischemia-reperfusion, or mitochondrial complex III inhibition with antimycin A [14].
  • Several agents have been suggested to possess chemopreventive potential against the development of HCC in chronic HCV-associated liver disease, including herbal medicines, such as Stronger-Neo-Minophagen C (glycyrrhizin) and Sho-saiko-to (TJ-9) [15].

Biological context of C10023


Anatomical context of C10023


Associations of C10023 with other chemical compounds


Gene context of C10023


Analytical, diagnostic and therapeutic context of C10023


  1. Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats. Shimizu, I., Ma, Y.R., Mizobuchi, Y., Liu, F., Miura, T., Nakai, Y., Yasuda, M., Shiba, M., Horie, T., Amagaya, S., Kawada, N., Hori, H., Ito, S. Hepatology (1999) [Pubmed]
  2. Effects of Sho-Saiko-to on hepatocarcinogenesis and 8-hydroxy-2'-deoxyguanosine formation. Shiota, G., Maeta, Y., Mukoyama, T., Yanagidani, A., Udagawa, A., Oyama, K., Yashima, K., Kishimoto, Y., Nakai, Y., Miura, T., Ito, H., Murawaki, Y., Kawasaki, H. Hepatology (2002) [Pubmed]
  3. The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase. Yano, H., Mizoguchi, A., Fukuda, K., Haramaki, M., Ogasawara, S., Momosaki, S., Kojiro, M. Cancer Res. (1994) [Pubmed]
  4. Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells. Nie, D., Krishnamoorthy, S., Jin, R., Tang, K., Chen, Y., Qiao, Y., Zacharek, A., Guo, Y., Milanini, J., Pages, G., Honn, K.V. J. Biol. Chem. (2006) [Pubmed]
  5. Effects of baicalein on beta-amyloid peptide-(25-35)-induced amnesia in mice. Wang, S.Y., Wang, H.H., Chi, C.W., Chen, C.F., Liao, J.F. Eur. J. Pharmacol. (2004) [Pubmed]
  6. Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats. Liu, C., Wu, J., Gu, J., Xiong, Z., Wang, F., Wang, J., Wang, W., Chen, J. Pharmacol. Biochem. Behav. (2007) [Pubmed]
  7. Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. Ma, Z., Otsuyama, K., Liu, S., Abroun, S., Ishikawa, H., Tsuyama, N., Obata, M., Li, F.J., Zheng, X., Maki, Y., Miyamoto, K., Kawano, M.M. Blood (2005) [Pubmed]
  8. Overexpression of platelet-type 12-lipoxygenase promotes tumor cell survival by enhancing alpha(v)beta(3) and alpha(v)beta(5) integrin expression. Pidgeon, G.P., Tang, K., Cai, Y.L., Piasentin, E., Honn, K.V. Cancer Res. (2003) [Pubmed]
  9. Hepatitis C and liver fibrosis. Schuppan, D., Krebs, A., Bauer, M., Hahn, E.G. Cell Death Differ. (2003) [Pubmed]
  10. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Zhang, D.Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., Li, X. Cancer Res. (2003) [Pubmed]
  11. Prostaglandin I2 contributes to the vasodepressor effect of baicalein in hypertensive rats. Takizawa, H., DelliPizzi, A.M., Nasjletti, A. Hypertension (1998) [Pubmed]
  12. Herbal medicine Sho-saiko-to (TJ-9) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. Sakaida, I., Matsumura, Y., Akiyama, S., Hayashi, K., Ishige, A., Okita, K. J. Hepatol. (1998) [Pubmed]
  13. Protective effects of baicalein and wogonin against benzo[a]pyrene- and aflatoxin B(1)-induced genotoxicities. Ueng, Y.F., Shyu, C.C., Liu, T.Y., Oda, Y., Lin, Y.L., Liao, J.F., Chen, C.F. Biochem. Pharmacol. (2001) [Pubmed]
  14. Baicalein attenuates oxidant stress in cardiomyocytes. Shao, Z.H., Vanden Hoek, T.L., Qin, Y., Becker, L.B., Schumacker, P.T., Li, C.Q., Dey, L., Barth, E., Halpern, H., Rosen, G.M., Yuan, C.S. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
  15. Ursodiol use is possibly associated with lower incidence of hepatocellular carcinoma in hepatitis C virus-associated liver cirrhosis. Tarao, K., Fujiyama, S., Ohkawa, S., Miyakawa, K., Tamai, S., Hirokawa, S., Masaki, T., Tanaka, K. Cancer Epidemiol. Biomarkers Prev. (2005) [Pubmed]
  16. Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells. Pidgeon, G.P., Kandouz, M., Meram, A., Honn, K.V. Cancer Res. (2002) [Pubmed]
  17. Novel hydrogen peroxide metabolism in suspension cells of Scutellaria baicalensis Georgi. Morimoto, S., Tateishi, N., Matsuda, T., Tanaka, H., Taura, F., Furuya, N., Matsuyama, N., Shoyama, Y. J. Biol. Chem. (1998) [Pubmed]
  18. Activation of 12-lipoxygenase in proinflammatory cytokine-mediated beta cell toxicity. Chen, M., Yang, Z.D., Smith, K.M., Carter, J.D., Nadler, J.L. Diabetologia (2005) [Pubmed]
  19. Sho-saiko-To: the right blend of traditional Oriental medicine and liver cell biology. Geerts, A., Rogiers, V. Hepatology (1999) [Pubmed]
  20. Cellular mechanism for potentiation of Ca2+-mediated Cl- secretion by the flavonoid baicalein in intestinal epithelia. Yue, G.G., Yip, T.W., Huang, Y., Ko, W.H. J. Biol. Chem. (2004) [Pubmed]
  21. Synergy of epidermal growth factor and 12(S)-hydroxyeicosatetraenoate on protein kinase C activation in lens epithelial cells. Zhou, J., Fariss, R.N., Zelenka, P.S. J. Biol. Chem. (2003) [Pubmed]
  22. Arachidonic acid metabolites in bFGF-, PDGF-, and serum-stimulated vascular cell growth. Dethlefsen, S.M., Shepro, D., D'Amore, P.A. Exp. Cell Res. (1994) [Pubmed]
  23. Mechanism of selective killing by dilinoleoylglycerol of cells transformed by the E1A gene of adenovirus type 12. Matsuzaki, A., Shimura, H., Okuda, A., Ohtsu, M., Sasaki, M., Onodera, K., Kimura, G. Cancer Res. (1989) [Pubmed]
  24. Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation. Alonso-Galicia, M., Hudetz, A.G., Shen, H., Harder, D.R., Roman, R.J. Stroke (1999) [Pubmed]
  25. Role of the lipoxygenase pathway in angiotensin II-induced vasoconstriction in the human placenta. Kisch, E.S., Jaffe, A., Knoll, E., Stern, N. Hypertension (1997) [Pubmed]
  26. Role of the lipoxygenase pathway in angiotensin II-mediated aldosterone biosynthesis in human adrenal glomerulosa cells. Natarajan, R., Stern, N., Hsueh, W., Do, Y., Nadler, J. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  27. Effects of the Japanese herbal medicine "Sho-saiko-to" (TJ-9) on in vitro interleukin-10 production by peripheral blood mononuclear cells of patients with chronic hepatitis C. Yamashiki, M., Nishimura, A., Suzuki, H., Sakaguchi, S., Kosaka, Y. Hepatology (1997) [Pubmed]
  28. The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics. Sugatani, J., Yamakawa, K., Tonda, E., Nishitani, S., Yoshinari, K., Degawa, M., Abe, I., Noguchi, H., Miwa, M. Biochem. Pharmacol. (2004) [Pubmed]
  29. Inhibition of cyclic strain-induced endothelin-1 secretion by baicalein in human umbilical vein endothelial cells. Chen, H.H., Hong, H.J., Chou, Y.H., Cheng, T.H., Chen, J.J., Lin, H. Planta Med. (2006) [Pubmed]
  30. Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells. Nakahata, N., Tsuchiya, C., Nakatani, K., Ohizumi, Y., Ohkubo, S. Eur. J. Pharmacol. (2003) [Pubmed]
  31. Baicalein inhibition of oxidative-stress-induced apoptosis via modulation of ERKs activation and induction of HO-1 gene expression in rat glioma cells C6. Chen, Y.C., Chow, J.M., Lin, C.W., Wu, C.Y., Shen, S.C. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  32. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Bonham, M., Posakony, J., Coleman, I., Montgomery, B., Simon, J., Nelson, P.S. Clin. Cancer Res. (2005) [Pubmed]
  33. Cloning and expression of UDP-glucose: flavonoid 7-O-glucosyltransferase from hairy root cultures of Scutellaria baicalensis. Hirotani, M., Kuroda, R., Suzuki, H., Yoshikawa, T. Planta (2000) [Pubmed]
  34. The effects of the cyclosporin A, a P-glycoprotein inhibitor, on the pharmacokinetics of baicalein in the rat: a microdialysis study. Tsai, T.H., Liu, S.C., Tsai, P.L., Ho, L.K., Shum, A.Y., Chen, C.F. Br. J. Pharmacol. (2002) [Pubmed]
  35. Inhibition of inducible nitric oxide synthase expression by baicalein in endotoxin/cytokine-stimulated microglia. Chen, C.J., Raung, S.L., Liao, S.L., Chen, S.Y. Biochem. Pharmacol. (2004) [Pubmed]
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