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Gene Review

CDH1  -  cadherin 1, type 1, E-cadherin (epithelial)

Gallus gallus

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Disease relevance of CDH1

  • Mouse L cells, which do not express the known primary cell adhesion molecules (CAMs), were permanently transfected with vectors containing the simian virus 40 early promoter and cDNA sequences encoding chicken liver CAM (L-CAM) or each of the three major polypeptide forms of chicken neural CAM (N-CAM) [1].
  • L-CAM expression induces fibroblast-epidermoid transition in squamous carcinoma cells and down-regulates the endogenous N-cadherin [2].
  • During the period when the otic vesicle differentiated to give rise to the acoustic ganglion and to the differentiated structures of the cochlea, N-CAM increased in the innervated sensory regions while L-CAM increased in the non-sensory areas of the auditory epithelium adjacent to the sensory regions [3].
  • As endothelial cadherins are thought to play a role in the dynamic response to acute lung injury, we utilized Western blot analysis to assess lung cadherin content and Northern blot analysis to assess pulmonary vascular endothelial (VE) cadherin expression following drug administration [4].
  • Chicken intestine epithelial cells typically expressed keratin and chicken E-cadherin, in contrast to chicken embryo fibroblasts, and they increased cell surface MHC II after activation with crude IFN-gamma containing supernatants, obtained from chicken spleen cells stimulated with concanavalin A or transformed by reticuloendotheliosis virus [5].

High impact information on CDH1


Biological context of CDH1


Anatomical context of CDH1

  • The profound effects of v-src on intercellular adhesion were not linked to changes in the levels of expression of the epithelial cell adhesion molecule E-cadherin [12].
  • The collar epithelium was both N-CAM- and L-CAM-positive [13].
  • N-CAM was found to be enriched in the dermal papilla, which was closely apposed to L-CAM-positive papillar ectoderm [14].
  • N-CAM-positive dermal condensations were distributed periodically under L-CAM-positive feather placodes at those sites where basement membranes are known to be disrupted [13].
  • In S180L cells and S180cadN cells, L-CAM and N-cadherin were seen at sites of adherens junctions but were not restricted to these areas [15].

Associations of CDH1 with chemical compounds

  • Rather, we observed an increase in tyrosine phosphorylation of E-cadherin and, in particular, of the associated protein beta-catenin [12].
  • When hepatocytes were grown in the presence of 32PO4, 32P was detected in phosphoserine and phosphothreonine residues of intact L-CAM, but little or no 32P was detected in Ft1, suggesting that L-CAM is phosphorylated in the carboxyl-terminal region [16].
  • In transient cotransfection experiments of NIH 3T3 cells, we observed that both HoxD9 and liver-enriched POU-homeodomain transcription factor, HNF-1, activated chloramphenicol acetyltransferase gene reporter constructs containing the L-CAM promoter and an enhancer present in the second intron of the chicken L-CAM gene [17].
  • The altered feather pattern obtained by disrupting proteoglycan structure is highly similar to that obtained when skins are cultured in the presence of antibodies to L-CAM (W.J. Gallin, C.-M., Chuong, L.H. Finkel, and G.M. Edelman (1986), Proc. Natl. Acad. Sci. USA 83, 8235-8239) [18].
  • In contrast, in the mesonephroi cultured in the presence of TDG and lactose, the epithelial tubular cells expressing E-cadherin also express vimentin [19].

Other interactions of CDH1

  • R-cadherin is a newly identified member of the cadherin family of cell adhesion receptors [20].
  • We then compared the primary structure of N-cadherin with that of other molecules defined as cadherin subclasses [21].
  • The sequence of the predicted gene product was nearly identical to that of the chicken B-cadherin cDNA, although the distribution of the K-CAM gene transcript differed from that reported for the cadherin [22].
  • During feather follicle formation, N-CAM was expressed in the dermal papilla and was closely apposed to the L-CAM-positive papillar ectoderm, while the dermal papilla showed no evidence of laminin or fibronectin [13].
  • Neural CAM (N-CAM), liver CAM (L-CAM), and neuron-glia CAM (Ng-CAM), as well as substrate molecules (laminin and fibronectin), were compared in newborn chicken skin by immunohistochemical means [14].

Analytical, diagnostic and therapeutic context of CDH1


  1. Cellular expression of liver and neural cell adhesion molecules after transfection with their cDNAs results in specific cell-cell binding. Edelman, G.M., Murray, B.A., Mege, R.M., Cunningham, B.A., Gallin, W.J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. L-CAM expression induces fibroblast-epidermoid transition in squamous carcinoma cells and down-regulates the endogenous N-cadherin. Li, Z., Gallin, W.J., Lauzon, G., Pasdar, M. J. Cell. Sci. (1998) [Pubmed]
  3. Expression of cell adhesion molecules during embryonic induction. III. Development of the otic placode. Richardson, G.P., Crossin, K.L., Chuong, C.M., Edelman, G.M. Dev. Biol. (1987) [Pubmed]
  4. Measurement of the filtration coefficient (Kfc) in the lung of Gallus domesticus and the effects of increased microvascular permeability. Weidner, W.J., Waddell, D.S., Furlow, J.D. J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. (2006) [Pubmed]
  5. Chicken primary enterocytes: inhibition of Eimeria tenella replication after activation with crude interferon-gamma supernatants. Dimier-Poisson, I.H., Bout, D.T., Quéré, P. Avian Dis. (2004) [Pubmed]
  6. Formation of heterotypic adherens-type junctions between L-CAM-containing liver cells and A-CAM-containing lens cells. Volk, T., Cohen, O., Geiger, B. Cell (1987) [Pubmed]
  7. Guidance of optic nerve fibres by N-cadherin adhesion molecules. Matsunaga, M., Hatta, K., Nagafuchi, A., Takeichi, M. Nature (1988) [Pubmed]
  8. Cadherins promote skeletal muscle differentiation in three-dimensional cultures. Redfield, A., Nieman, M.T., Knudsen, K.A. J. Cell Biol. (1997) [Pubmed]
  9. The cadherin-binding specificities of B-cadherin and LCAM. Murphy-Erdosh, C., Yoshida, C.K., Paradies, N., Reichardt, L.F. J. Cell Biol. (1995) [Pubmed]
  10. Structure of the gene for the liver cell adhesion molecule, L-CAM. Sorkin, B.C., Hemperly, J.J., Edelman, G.M., Cunningham, B.A. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  11. Sequence analysis of a cDNA clone encoding the liver cell adhesion molecule, L-CAM. Gallin, W.J., Sorkin, B.C., Edelman, G.M., Cunningham, B.A. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  12. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. Behrens, J., Vakaet, L., Friis, R., Winterhager, E., Van Roy, F., Mareel, M.M., Birchmeier, W. J. Cell Biol. (1993) [Pubmed]
  13. Expression of cell-adhesion molecules in embryonic induction. I. Morphogenesis of nestling feathers. Chuong, C.M., Edelman, G.M. J. Cell Biol. (1985) [Pubmed]
  14. Expression of cell-adhesion molecules in embryonic induction. II. Morphogenesis of adult feathers. Chuong, C.M., Edelman, G.M. J. Cell Biol. (1985) [Pubmed]
  15. cDNAs of cell adhesion molecules of different specificity induce changes in cell shape and border formation in cultured S180 cells. Matsuzaki, F., Mège, R.M., Jaffe, S.H., Friedlander, D.R., Gallin, W.J., Goldberg, J.I., Cunningham, B.A., Edelman, G.M. J. Cell Biol. (1990) [Pubmed]
  16. Linear organization of the liver cell adhesion molecule L-CAM. Cunningham, B.A., Leutzinger, Y., Gallin, W.J., Sorkin, B.C., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  17. Regulation in vitro of an L-CAM enhancer by homeobox genes HoxD9 and HNF-1. Goomer, R.S., Holst, B.D., Wood, I.C., Jones, F.S., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  18. Altered proteoglycan synthesis disrupts feather pattern formation in chick embryonic skin. Goetinck, P.F., Carlone, D.L. Dev. Biol. (1988) [Pubmed]
  19. Endogenous galectins and effect of galectin hapten inhibitors on the differentiation of the chick mesonephros. Murphy, K.M., Zalik, S.E. Dev. Dyn. (1999) [Pubmed]
  20. Differential expression of R- and N-cadherin in neural and mesodermal tissues during early chicken development. Inuzuka, H., Redies, C., Takeichi, M. Development (1991) [Pubmed]
  21. Cloning and expression of cDNA encoding a neural calcium-dependent cell adhesion molecule: its identity in the cadherin gene family. Hatta, K., Nose, A., Nagafuchi, A., Takeichi, M. J. Cell Biol. (1988) [Pubmed]
  22. Genes for two calcium-dependent cell adhesion molecules have similar structures and are arranged in tandem in the chicken genome. Sorkin, B.C., Gallin, W.J., Edelman, G.M., Cunningham, B.A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  23. Isolation of a cDNA clone for the liver cell adhesion molecule (L-CAM). Gallin, W.J., Prediger, E.A., Edelman, G.M., Cunningham, B.A. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  24. Early epochal maps of two different cell adhesion molecules. Edelman, G.M., Gallin, W.J., Delouvée, A., Cunningham, B.A., Thiery, J.P. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  25. Cell sorting-out is modulated by both the specificity and amount of different cell adhesion molecules (CAMs) expressed on cell surfaces. Friedlander, D.R., Mège, R.M., Cunningham, B.A., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  26. Occludin is a functional component of the tight junction. McCarthy, K.M., Skare, I.B., Stankewich, M.C., Furuse, M., Tsukita, S., Rogers, R.A., Lynch, R.D., Schneeberger, E.E. J. Cell. Sci. (1996) [Pubmed]
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