Disease relevance of Pgaipg

• PGAIPG, a repeated hexapeptide of bovine and human tropoelastin, is chemotactic for neutrophils and Lewis lung carcinoma cells [1].

High impact information on Pgaipg

• pH- and thermal-dependent conformational transition of PGAIPG, a repeated hexapeptide sequence from tropoelastin [2].
• VGVAPG desensitized neutrophils to migration induced by PGAIPG confirming that PGAIPG was binding to the 67-kDa receptor [1].
• Recently, studies utilizing recombinant tropoelastin deletion proteins in conjunction with synthetic peptides identified a second fibroblast receptor binding site, PGAIPG [1].
• PGAIPG, a repeated hexapeptide of bovine tropoelastin, is a ligand for the 67-kDa bovine elastin receptor [3].
• Experiments using synthetic peptides contained within these proteins identify a chemotactic peptide, PGAIPG, and a chemokinetic peptide, GAIPG, PGAIPG was identified as a ligand for the bovine elastin receptor [3].

Gene context of Pgaipg

• To evaluate whether PGAIPG is a ligand for elastin receptors of other cells, the chemotactic response of neutrophils and Lewis lung carcinoma tumor cells (M27) was studied [1].

Analytical, diagnostic and therapeutic context of Pgaipg

• The thermal-dependent structural change of PGAIPG in aqueous solution or in solid state was also examined by thermal FTIR microspectroscopy [2].

References