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Chemical Compound Review

Vgvapg     2-[[(2S)-1-[(2S)-2-[[(2S)-2- [2-[[(2S)-2...

Synonyms: SureCN1404295, AC1L3ZDD, CTK8D8736, AR-1J3530, 92899-39-3, ...
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Disease relevance of Val-gly-ala-pro-gly

  • The hexapeptide VGVAPG is a particularly potent chemotaxin for lung-colonizing Lewis lung carcinoma cells (line M27), with 5 nM VGVAPG eliciting maximal chemotactic response when assayed in 48-microwell chemotaxis chambers [1].
  • To explore the possibility that tropoelastin contains additional peptide ligands for this elastin receptor, we have constructed two deletion proteins that are expressed in E. coli and lack the repeated VGVAPG sequence [2].

High impact information on Val-gly-ala-pro-gly


Biological context of Val-gly-ala-pro-gly


Anatomical context of Val-gly-ala-pro-gly


Associations of Val-gly-ala-pro-gly with other chemical compounds

  • We designed hybrid peptides, SIRVXVXPG (X: A or G), from a laminin-derived peptide, SIKVAV, and an elastin-derived peptide, VGVAPG, and tried to develop new alginate dressings linked covalently with the hybrid peptides [14].

Gene context of Val-gly-ala-pro-gly

  • Collectively, these data support a model whereby the elastin gene product, signaling through the VGVAPG domain, directly induces VSMC myofibrillogenesis [7].
  • In the present study, we show that kappa-elastin and VGVAPG hexapeptide elastin motif accelerated angiogenesis in the chick chorio-allantoic membrane in an in vivo model [15].
  • The hexapeptide repeat VGVAPG, the bovine elastin receptor binding peptide, is not encoded by rat tropoelastin cDNAs [16].
  • A hydrophobic peptide, VGVAPG, has been shown to be a ligand for a 67-kDa elastin cell surface receptor expressed on fetal bovine auricular chondrocytes and ligamentum nuchae fibroblasts [2].


  1. Identification of a tumor cell receptor for VGVAPG, an elastin-derived chemotactic peptide. Blood, C.H., Sasse, J., Brodt, P., Zetter, B.R. J. Cell Biol. (1988) [Pubmed]
  2. PGAIPG, a repeated hexapeptide of bovine tropoelastin, is a ligand for the 67-kDa bovine elastin receptor. Grosso, L.E., Scott, M. Matrix (1993) [Pubmed]
  3. Action of tropoelastin and synthetic elastin sequences on vascular tone and on free Ca2+ level in human vascular endothelial cells. Faury, G., Garnier, S., Weiss, A.S., Wallach, J., Fülöp, T., Jacob, M.P., Mecham, R.P., Robert, L., Verdetti, J. Circ. Res. (1998) [Pubmed]
  4. Laminin regulates a tumor cell chemotaxis receptor through the laminin-binding integrin subunit alpha 6. Blood, C.H., Zetter, B.R. Cancer Res. (1993) [Pubmed]
  5. Tropoelastin interacts with cell-surface glycosaminoglycans via its COOH-terminal domain. Broekelmann, T.J., Kozel, B.A., Ishibashi, H., Werneck, C.C., Keeley, F.W., Zhang, L., Mecham, R.P. J. Biol. Chem. (2005) [Pubmed]
  6. Peptide sequences selected by BA4, a tropoelastin-specific monoclonal antibody, are ligands for the 67-kilodalton bovine elastin receptor. Grosso, L.E., Scott, M. Biochemistry (1993) [Pubmed]
  7. Elastin induces myofibrillogenesis via a specific domain, VGVAPG. Karnik, S.K., Wythe, J.D., Sorensen, L., Brooke, B.S., Urness, L.D., Li, D.Y. Matrix Biol. (2003) [Pubmed]
  8. Cell-physiological effects of elastin derived (VGVAPG)n oligomers in a unicellular model system. Köhidai, L., Kun, L., Eva, P., Csaba, G., Mihala, N., Majer, Z., Süli-Vargha, H. J. Pept. Sci. (2004) [Pubmed]
  9. Modulation by elastin peptide VGVAPG of cell proliferation and elastin expression in human skin fibroblasts. Tajima, S., Wachi, H., Uemura, Y., Okamoto, K. Arch. Dermatol. Res. (1997) [Pubmed]
  10. Elastin peptides induce migration and terminal differentiation of cultured keratinocytes via 67 kDa elastin receptor in vitro: 67 kDa elastin receptor is expressed in the keratinocytes eliminating elastic materials in elastosis perforans serpiginosa. Fujimoto, N., Tajima, S., Ishibashi, A. J. Invest. Dermatol. (2000) [Pubmed]
  11. Matrix-directed regulation of pericellular proteolysis and tumor progression. Hornebeck, W., Emonard, H., Monboisse, J.C., Bellon, G. Semin. Cancer Biol. (2002) [Pubmed]
  12. PGAIPG, a repeated hexapeptide of bovine and human tropoelastin, is chemotactic for neutrophils and Lewis lung carcinoma cells. Grosso, L.E., Scott, M. Arch. Biochem. Biophys. (1993) [Pubmed]
  13. Mimicry of elastin repetitive motifs by Theileria annulata sporozoite surface antigen. Hall, R., Hunt, P.D., Carrington, M., Simmons, D., Williamson, S., Mecham, R.P., Tait, A. Mol. Biochem. Parasitol. (1992) [Pubmed]
  14. Development of alginate wound dressings linked with hybrid peptides derived from laminin and elastin. Hashimoto, T., Suzuki, Y., Tanihara, M., Kakimaru, Y., Suzuki, K. Biomaterials (2004) [Pubmed]
  15. Elastin-derived peptides enhance angiogenesis by promoting endothelial cell migration and tubulogenesis through upregulation of MT1-MMP. Robinet, A., Fahem, A., Cauchard, J.H., Huet, E., Vincent, L., Lorimier, S., Antonicelli, F., Soria, C., Crepin, M., Hornebeck, W., Bellon, G. J. Cell. Sci. (2005) [Pubmed]
  16. Heterogeneity of rat tropoelastin mRNA revealed by cDNA cloning. Pierce, R.A., Deak, S.B., Stolle, C.A., Boyd, C.D. Biochemistry (1990) [Pubmed]
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