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Chemical Compound Review:

bacillosamine (2R,3S,4R,5R)-2,4-diamino- 3,5-dihydroxy...

Synonyms: AG-K-71601, CHEBI:32538, CTK5D1905, AR-1D3393, AC1L4V2T, ...

Singh, S. et al., Schoenhofen, I.C. et al., Creuzenet, C., Young, N.M. et al.

Creuzenet, Young, Brisson, Kelly, Watson, Tessier, Lanthier, Jarrell, Cadotte, St Michael, Aberg, Szymanski,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of bacillosamine

Comparison of the pgl locus with that of Neisseria meningitidis suggested that most of the homologous genes are probably involved in the biosynthesis of bacillosamine [1].
Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways [2].
The O-specific polysaccharide from the lipopolysaccharide of Pseudomonas aeruginosa NCTC 8505 (IATS serotype O:3) consists of a tetrasaccharide repeating unit comprising L-rhamnose, N-acetyl-D-glucosamine (GlcNAc), bacillosamine, and N-acetyl-L-galactosaminuronic acid (L-GalNAcA) (Y. Tahara and S. G. Wilkinson, Eur. J. Biochem. 134:299-304, 1983) [3].

High impact information on bacillosamine

Based on enzymatic data, we propose that CJ1293 catalyzes the first step in the biosynthesis of bacillosamine, a sugar found in C. jejuni's protein glycosylation motifs [4].

References

Structure of the N-linked glycan present on multiple glycoproteins in the Gram-negative bacterium, Campylobacter jejuni. Young, N.M., Brisson, J.R., Kelly, J., Watson, D.C., Tessier, L., Lanthier, P.H., Jarrell, H.C., Cadotte, N., St Michael, F., Aberg, E., Szymanski, C.M. J. Biol. Chem. (2002) [Pubmed]
Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways. Schoenhofen, I.C., McNally, D.J., Vinogradov, E., Whitfield, D., Young, N.M., Dick, S., Wakarchuk, W.W., Brisson, J.R., Logan, S.M. J. Biol. Chem. (2006) [Pubmed]
Formation of UDP-2-acetamido-2-deoxy-L-galactose and UDP-2-acetamido-2-deoxy-L-galacturonic acid by Pseudomonas aeruginosa. Singh, S., Singh, U., Hogan, S.E., Feingold, D.S. J. Bacteriol. (1990) [Pubmed]
Characterization of CJ1293, a new UDP-GlcNAc C6 dehydratase from Campylobacter jejuni. Creuzenet, C. FEBS Lett. (2004) [Pubmed]

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