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Chemical Compound Review

AG-K-07706     ethanamine; nitric acid

Synonyms: CTK1A3439, AR-1I7267, CAS-22113-86-6, AC1L4WL8, AC1Q21W6, ...
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High impact information on Ethylammonium

  • At position 373, substitution of Arg or Cys also strongly accelerated desensitization: however, in the case of K373C the wild-type phenotype was fully restored by adding ethylammonium methanethiosulfonate [1].
  • Association of ethylammonium and perchlorate ions with unenergized submitochondrial particles was measured by centrifugation, in the presence of a high concentration of impermeant salt to minimize association with the external surface [2].
  • By incubating human embryonic kidney 293 cells stably transfected with CB2 receptors and MTS derivatives such as MTS ethylammonium (MTSEA), [(3)H]HU-243 binding was inhibited [3].
  • Alanine mutants of endogenous hNET cysteines, hC86A, hC131A and hC339A, were examined and showed no marked effects on expression or function. hNET and the mutants were also resistant to methanethiosulfonate (MTS), ethylammonium (MTSEA) and MTStrimethylammonium (MTSET) [4].
  • The barrier to ethylammonium entry was prohibitive at 21 kcal/mol, whereas for methylammonium it was 5.5 kcal/mol, and the profile was quite flat through the channel, roughly consistent with conductance measurements [5].

Associations of Ethylammonium with other chemical compounds


Gene context of Ethylammonium

  • The progressive reduction of charge in charge states of non-denatured proteins (lysozyme, ubiquitin, and cytochrome c), observed with nanospray in the positive ion mode, when the buffer salt ammonium acetate is replaced by ethylammonium acetates (EtNH(3)Ac, Et(2)NH(2)Ac and Et(3)NHAc) is rationalized on the basis of the charge residue model (CRM) [8].


  1. A C-terminal lysine that controls human P2X4 receptor desensitization. Fountain, S.J., North, R.A. J. Biol. Chem. (2006) [Pubmed]
  2. Measurement of the electrochemical proton gradient in submitochondrial particles. Berry, E.A., Hinkle, P.C. J. Biol. Chem. (1983) [Pubmed]
  3. Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template. Zhang, R., Hurst, D.P., Barnett-Norris, J., Reggio, P.H., Song, Z.H. Mol. Pharmacol. (2005) [Pubmed]
  4. Roles of transmembrane domain 2 and the first intracellular loop in human noradrenaline transporter function: pharmacological and SCAM analysis. Sucic, S., Bryan-Lluka, L.J. J. Neurochem. (2005) [Pubmed]
  5. Molecular dynamics study of free energy profiles for organic cations in gramicidin A channels. Hao, Y., Pear, M.R., Busath, D.D. Biophys. J. (1997) [Pubmed]
  6. Ethylammonium formate as an organic solvent replacement for ion-pair reversed-phase liquid chromatography. Waichigo, M.M., Danielson, N.D. Journal of chromatographic science (2006) [Pubmed]
  7. Self-assembly of nonionic surfactants into lyotropic liquid crystals in ethylammonium nitrate, a room-temperature ionic liquid. Araos, M.U., Warr, G.G. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005) [Pubmed]
  8. Effect of buffer cations and of H3O+ on the charge states of native proteins. Significance to determinations of stability constants of protein complexes. Verkerk, U.H., Peschke, M., Kebarle, P. Journal of mass spectrometry : JMS. (2003) [Pubmed]
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