High impact information on LN 5330

• In the isolated rat pancreas perfused with 8.3 mmol/l glucose, the infusion of LN 5330 (440 mumol/l for 30 min) induced a drastic fall in insulin and a rapid and persistent increase in glucagon output [1].
• In the absence of glucose, 86Rb+ permeability also increased, LN 5330 being again significantly more efficient than diazoxide at an equimolar concentration [2].
• The present study was carried out to investigate the effects of LN 5330 on insulin release and 86Rb- efflux from perifused rat pancreatic islets; a comparison was made with the structural analogue diazoxide [2].
• These data indicate that the benzothiadiazine derivative LN 5330 inhibits insulin secretion by increasing the potassium permeability of the plasma membrane [2].
• Diazoxide and somatostatin were infused at concentrations which induced an inhibitory effect similar to that obtained with LN 5330 (15 mg/l) [3].

Associations of LN 5330 with other chemical compounds

• These findings show that LN 5330 is a substance which is distinct from diazoxide and interesting because of its double action: inhibition of insulin secretion and stimulation of glucagon secretion [1].

References