Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL99099 7-[3-[2-(cyclopropylmethyl)- 3-methoxy-4-(1...

Synonyms: SureCN1891598, CHEBI:260414, AC1L4BTS, SC-50605, SC 50605, ...

Penning, T.D. et al., Fretland, D.J. et al.

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High impact information on SC 50605

Leukotriene B4-induced granulocyte trafficking in guinea pig dermis. Effect of second-generation leukotriene B4 receptor antagonists, SC-50605 and SC-51146 [1].
Exhaustive SAR studies found a potential backup compound, SC-50605, which was 7-16 times more potent than SC-41930 in LTB4 receptor binding, chemotaxis and degranulation assays [2].

References

Leukotriene B4-induced granulocyte trafficking in guinea pig dermis. Effect of second-generation leukotriene B4 receptor antagonists, SC-50605 and SC-51146. Fretland, D.J., Widomski, D.L., Anglin, C.P., Penning, T.D., Yu, S., Djuric, S.W. Inflammation (1993) [Pubmed]
The design and synthesis of second generation leukotriene B4 (LTB4) receptor antagonists related to SC-41930. Penning, T.D., Djuric, S.W., Docter, S.H., Yu, S.S., Spangler, D., Anglin, C.P., Fretland, D.J., Kachur, J.F., Keith, R.H., Tsai, B.S. Agents Actions (1993) [Pubmed]

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