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Chemical Compound Review

BioMed 101     7-[3-(4-ethanoyl-3-methoxy-2- propyl...

Synonyms: CHEMBL14823, SureCN1889110, ACMC-20mopq, CHEBI:115330, AC1L3GCN, ...
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Disease relevance of SC 41930

  • Mucin purified from additional animals with hapten-induced colitis but treated with the oral leukotriene B4-receptor antagonist SC-41930 showed intermediate inhibition of RDEC-1 binding (35.6% +/- 14.3%) [1].
  • We evaluated the efficacy of 7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)-3,4-dihydro-8-propyl -2H-1-benzopyran-2-carboxylic acid (SC-41930), a potent, orally active leukotriene B4 receptor antagonist, in a model of inflammatory bowel disease [2].
  • Compounds such as SC-41930 may well have utility for treating human psoriasis [3].
  • The PMA-induced skin inflammation model also was assessed histologically and revealed acanthosis, edema, PMNL infiltration, and rete ridge prominence as long as 96 h after a single application that was completely inhibited by SC-41930 topical coapplication [4].
  • SC-41930 also very significantly protected rats against pulmonary oxygen toxicity, but had only marginally significant effects on pulmonary protection in mice [5].

High impact information on SC 41930


Biological context of SC 41930


Anatomical context of SC 41930


Associations of SC 41930 with other chemical compounds


Gene context of SC 41930


Analytical, diagnostic and therapeutic context of SC 41930


  1. Effect of colonic inflammation on mucin inhibition of Escherichia coli RDEC-1 binding in vitro. Mack, D.R., Gaginella, T.S., Sherman, P.M. Gastroenterology (1992) [Pubmed]
  2. Effect of the leukotriene B4 receptor antagonist SC-41930 on colonic inflammation in rat, guinea pig and rabbit. Fretland, D.J., Widomski, D., Tsai, B.S., Zemaitis, J.M., Levin, S., Djuric, S.W., Shone, R.L., Gaginella, T.S. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  3. SC-41930 inhibits neutrophil infiltration of the cavine dermis induced by 12(R)-hydroxyeicosatetraenoic acid. Fretland, D.J., Widomski, D.L., Shone, R.L., Penning, T.D., Miyashiro, J.M., Djuric, S.W. Prostaglandins Leukot. Essent. Fatty Acids (1989) [Pubmed]
  4. Inflammation of guinea pig dermis. Effects of leukotriene B4 receptor antagonist, SC-41930. Fretland, D.J., Widomski, D.L., Zemaitis, J.M., Walsh, R.E., Levin, S., Djuric, S.W., Shone, R.L., Tsai, B.S., Gaginella, T.S. Inflammation (1990) [Pubmed]
  5. Are leukotrienes or PAF involved in hyperbaric oxygen toxicity? Lin, Y., Jamieson, D. Agents Actions (1993) [Pubmed]
  6. Role of leukotriene B4 in granulocyte infiltration into the postischemic feline intestine. Zimmerman, B.J., Guillory, D.J., Grisham, M.B., Gaginella, T.S., Granger, D.N. Gastroenterology (1990) [Pubmed]
  7. Leukotriene B4 mediates shear rate-dependent leukocyte adhesion in mesenteric venules. Bienvenu, K., Russell, J., Granger, D.N. Circ. Res. (1992) [Pubmed]
  8. Signal transduction mechanisms for leukotriene B4 induced hyperadhesiveness of endothelial cells for neutrophils. Palmblad, J., Lerner, R., Larsson, S.H. J. Immunol. (1994) [Pubmed]
  9. Blockade of human neutrophil activation by 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]propoxy]phenoxy]benzoic acid (LY293111), a novel leukotriene B4 receptor antagonist. Marder, P., Sawyer, J.S., Froelich, L.L., Mann, L.L., Spaethe, S.M. Biochem. Pharmacol. (1995) [Pubmed]
  10. Multiple actions of the leukotriene B4 receptor antagonist SC-41930. Villani-Price, D., Yang, D.C., Walsh, R.E., Fretland, D.J., Keith, R.H., Kocan, G., Kachur, J.F., Gaginella, T.S., Tsai, B.S. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  11. Second-generation leukotriene B4 receptor antagonists related to SC-41930: heterocyclic replacement of the methyl ketone pharmacophore. Penning, T.D., Djuric, S.W., Miyashiro, J.M., Yu, S., Snyder, J.P., Spangler, D., Anglin, C.P., Fretland, D.J., Kachur, J.F., Keith, R.H. J. Med. Chem. (1995) [Pubmed]
  12. Effect of SC-41930, a potent selective leukotriene B4 receptor antagonist, in the guinea pig model of middle ear inflammation. Sutbeyaz, Y., Yakan, B., Ozdemir, H., Karasen, M., Doner, F., Kufrevioglu, I. The Annals of otology, rhinology, and laryngology. (1996) [Pubmed]
  13. The leukotriene B4 receptor agonist/antagonist activities of SC-45694 in human neutrophils. Tsai, B.S., Keith, R.H., Villani-Price, D., Haack, R.A., Djuric, S.W. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  14. Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy. Vaananen, P.M., Keenan, C.M., Grisham, M.B., Wallace, J.L. Inflammation (1992) [Pubmed]
  15. Comparative evaluation of arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation. Rao, T.S., Currie, J.L., Shaffer, A.F., Isakson, P.C. Inflammation (1993) [Pubmed]
  16. The antiinflammatory agent SC-41930 inhibits granulocyte infiltration of the rodent dermis induced by 6-trans-leukotriene B4. Fretland, D.J., Widomski, D.L., Anglin, C.P., Gaginella, T.S. Prostaglandins Leukot. Essent. Fatty Acids (1991) [Pubmed]
  17. SC-41930: an inhibitor of leukotriene B4-stimulated human neutrophil functions. Tsai, B.S., Villani-Price, D., Keith, R.H., Zemaitis, J.M., Bauer, R.F., Leonard, R., Djuric, S.W., Shone, R.L. Prostaglandins (1989) [Pubmed]
  18. Modulation of the chemotactic properties of complement fragments C5a and C3 by the anti-inflammatory agent, SC-41930. Fretland, D.J., Widomski, D.L., Anglin, C.P., Levin, S., Gaginella, T.S. Agents Actions (1991) [Pubmed]
  19. The design and synthesis of second generation leukotriene B4 (LTB4) receptor antagonists related to SC-41930. Penning, T.D., Djuric, S.W., Docter, S.H., Yu, S.S., Spangler, D., Anglin, C.P., Fretland, D.J., Kachur, J.F., Keith, R.H., Tsai, B.S. Agents Actions (1993) [Pubmed]
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