Disease relevance of carbenicillin

• Carbenicillin disodium was temporally associated with eight episodes of a mild reversible anicteric hepatitis characterized by nausea, vomiting, and a tender, somewhat enlarged liver [1].
• In order to study the mechanism of hypokalemic alkalosis which occurs in some patients being treated with disodium carbenicillin, renal clearance experiments were carried out in rats and observations were made on electrical changes in isolated toad bladders [2].
• A second patient in whom hemorrhagic cystitis due to carbenicillin disodium developed experienced this related disorder four years later when first exposed to ticarcillin [3].

High impact information on carbenicillin

• Patients with urinary tract infections were given 150 mg/kg/day of piperacillin sodium or 200 mg/kg/day or carbenicillin sodium in divided doses every six hours intravenously [4].
• The intestinal absorption of alpha-esters of carbenicillin disodium, carbenicillin phenyl sodium, and carbenicillin indanyl sodium was investigated using the in situ rat intestinal recirculating method [5].
• Effects of particulate matter from carbenicillin disodium solution on human macrophages in vitro [6].

Anatomical context of carbenicillin

• The effects of particulate matter from reconstituted carbenicillin disodium on cultures of human macrophages was studied [6].

Analytical, diagnostic and therapeutic context of carbenicillin

• It is concluded that packaging of carbenicillin disodium by lyophilization of a solution results in significantly less submicrometer particulate contamination than packaging by sterile bulk filling of spray-dried powder [7].
• Study of particulate matter in carbenicillin disodium using scanning electron microscopy and microbeam x-ray spectrography [7].

References