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Chemical Compound Review

Carbecin     disodium(2R,5R,6S)-6-[(2- carboxylato-2...

Synonyms: Gripenin, Anabactyl, Pyocianil, Pyoclox, Fugacillin, ...
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Disease relevance of carbenicillin

  • Carbenicillin disodium was temporally associated with eight episodes of a mild reversible anicteric hepatitis characterized by nausea, vomiting, and a tender, somewhat enlarged liver [1].
  • In order to study the mechanism of hypokalemic alkalosis which occurs in some patients being treated with disodium carbenicillin, renal clearance experiments were carried out in rats and observations were made on electrical changes in isolated toad bladders [2].
  • A second patient in whom hemorrhagic cystitis due to carbenicillin disodium developed experienced this related disorder four years later when first exposed to ticarcillin [3].

High impact information on carbenicillin


Anatomical context of carbenicillin


Analytical, diagnostic and therapeutic context of carbenicillin


  1. Anicteric carbenicillin hepatitis. Eight episodes in four patients. Wilson, F.M., Belamaric, J., Lauter, C.B., Lerner, A.M. JAMA (1975) [Pubmed]
  2. The behavior of carbenicillin as a nonreabsorbable anion. Lipner, H.I., Ruzany, F., Dasgupta, M., Lief, P.D., Bank, N. J. Lab. Clin. Med. (1975) [Pubmed]
  3. Ticarcillin-induced cystitis. Cross-reactivity with related penicillins. Marx, C.M., Alpert, S.E. Am. J. Dis. Child. (1984) [Pubmed]
  4. Piperacillin v Carbenicillin in the therapy for serious infections. Marier, R.L., Sanders, C.V., Faro, S., Janney, A., Williams, W.W., Derks, F., Aldridge, K.E. Arch. Intern. Med. (1982) [Pubmed]
  5. Carbenicillin prodrugs: kinetics of intestinal absorption competing degradation of the alpha-esters of carbenicillin and prediction of prodrug absorbability from quantitative structure-absorption rate relationship. Tsuji, A., Miyamoto, E., Terasaki, T., Yamana, T. Journal of pharmaceutical sciences. (1982) [Pubmed]
  6. Effects of particulate matter from carbenicillin disodium solution on human macrophages in vitro. Tabaka, M.S., Bollinger, R.O., McClain, P.R., Ottenbreit, M. American journal of hospital pharmacy. (1981) [Pubmed]
  7. Study of particulate matter in carbenicillin disodium using scanning electron microscopy and microbeam x-ray spectrography. Bollinger, R.O., Preuss, A.M., McClain, P.R., Hill, W.T. American journal of hospital pharmacy. (1978) [Pubmed]
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