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Chemical Compound Review

TIPC     (2R,5R,6S)-6-[(2-carboxy-2- thiophen-3-yl...

Synonyms: CHEMBL1449, BSPBio_001054, SureCN10738099, SPBio_002967, KST-1A4182, ...
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Disease relevance of TICARCILLIN


High impact information on TICARCILLIN


Chemical compound and disease context of TICARCILLIN


Biological context of TICARCILLIN


Anatomical context of TICARCILLIN


Associations of TICARCILLIN with other chemical compounds


Gene context of TICARCILLIN

  • The ranges of minimum inhibitory concentrations (MICs) of ticarcillin for beta-lactamase nonproducers of MSSA, MRSA, H. influenzae, E. coli, P. vulgaris, S. marcescens, E. cloacae, B. fragilis and beta-lactamase producers of MSSA, H. influenzae strains were all within the in vitro susceptible range [26].
  • Ticarcillin MICs for beta-lactamase-producing Haemophilus influenzae, Neisseria gonorrhoeae, and most Staphylococcus aureus were reduced to less than or equal to 0.5 micrograms/ml when CA was added [27].
  • Forty-three hospitalized patients were treated with a new antibiotic combination containing ticarcillin plus the beta-lactamase inhibitor, clavulanic acid, in a fixed combination for intravenous use [28].
  • In P. aeruginosa Pa695, a higher level of resistance to ceftazidime than to ticarcillin was observed, and no synergy between the beta-lactamase inhibitors and extended-spectrum cephalosporins was detected, in contrast to the resistance pattern observed in K. pneumoniae [29].
  • A high-pressure liquid chromatographic method for determining the concentrations of ticarcillin in serum was developed and compared, with 93 patient sera, to a standard agar well diffusion bioassay [30].

Analytical, diagnostic and therapeutic context of TICARCILLIN


  1. In vivo inactivation of tobramycin by ticarcillin. A case report. Chow, M.S., Quintiliani, R., Nightingale, C.H. JAMA (1982) [Pubmed]
  2. Severe neutropenia associated with ticarcillin therapy. Gastineau, D., Spector, R., Philips, D. Ann. Intern. Med. (1981) [Pubmed]
  3. Dose-dependent inhibition of experimental arterial thrombosis by carbenicillin and ticarcillin. Lyman, B.T., Johnson, G.J., White, J.G. Am. J. Pathol. (1978) [Pubmed]
  4. Safety and effectiveness of ticarcillin plus clavulanate potassium in treatment of lower respiratory tract infections. Mostow, S.R., O'Brien, R.F. Am. J. Med. (1985) [Pubmed]
  5. Safety and effectiveness of ticarcillin plus clavulanic acid in the treatment of community-acquired acute pyelonephritis in adult women. Sanders, C.V., Marier, R.L., Aldridge, K.E., Derks, F.W., Martin, D.H. Am. J. Med. (1985) [Pubmed]
  6. Protection by antibiotics against myeloperoxidase-dependent cytotoxicity to lung epithelial cells in vitro. Cantin, A., Woods, D.E. J. Clin. Invest. (1993) [Pubmed]
  7. Comparative study of ticarcillin plus clavulanate potassium versus piperacillin in the treatment of hospitalized patients with urinary tract infections. Cox, C.E. Am. J. Med. (1985) [Pubmed]
  8. Piperacillin or ticarcillin plus amikacin. A double-blind prospective comparison of empiric antibiotic therapy for febrile granulocytopenic cancer patients. Wade, J.C., Schimpff, S.C., Newman, K.A., Fortner, C.L., Standiford, H.C., Wiernik, P.H. Am. J. Med. (1981) [Pubmed]
  9. Clavulanate induces expression of the Pseudomonas aeruginosa AmpC cephalosporinase at physiologically relevant concentrations and antagonizes the antibacterial activity of ticarcillin. Lister, P.D., Gardner, V.M., Sanders, C.C. Antimicrob. Agents Chemother. (1999) [Pubmed]
  10. Comparative bactericidal effects of azlocillin and ticarcillin against Pseudomonas aeruginosa. White, A.R., Comber, K.R., Sutherland, R. Antimicrob. Agents Chemother. (1980) [Pubmed]
  11. Impact of dosing intervals on activity of gentamicin and ticarcillin against Pseudomonas aeruginosa in granulocytopenic mice. Gerber, A.U., Craig, W.A., Brugger, H.P., Feller, C., Vastola, A.P., Brandel, J. J. Infect. Dis. (1983) [Pubmed]
  12. A controlled study of ticarcillin plus clavulanic acid versus piperacillin as empiric therapy for fever in the immunocompromised host. Williams, M.E., Harman, C., Scheld, M., Hess, C.E., Donowitz, G.R. Am. J. Med. (1985) [Pubmed]
  13. Pharmacokinetics of ticarcillin in patients with cystic fibrosis: a controlled prospective study. de Groot, R., Hack, B.D., Weber, A., Chaffin, D., Ramsey, B., Smith, A.L. Clin. Pharmacol. Ther. (1990) [Pubmed]
  14. Disposition of drugs in cystic fibrosis. IV. Mechanisms for enhanced renal clearance of ticarcillin. Wang, J.P., Unadkat, J.D., al-Habet, S.M., O'Sullivan, T.A., Williams-Warren, J., Smith, A.L., Ramsey, B. Clin. Pharmacol. Ther. (1993) [Pubmed]
  15. Kinetics of intravenous mezlocillin in chronic hemodialysis patients. Francke, E., Mehta, S., Neu, H.C., Appel, G.B. Clin. Pharmacol. Ther. (1979) [Pubmed]
  16. Effects of apalcillin on platelet function in normal volunteers. Gentry, L.O., Wood, B.A., Natelson, E.A. Antimicrob. Agents Chemother. (1985) [Pubmed]
  17. A multicenter comparative trial of tobramycin and ticarcillin vs moxalactam and ticarcillin in febrile neutropenic patients. Feld, R., Louie, T.J., Mandell, L., Bow, E.J., Robson, H.G., Chow, A., Belch, A., Miedzinski, L., Rachlis, A., Pater, J. Arch. Intern. Med. (1985) [Pubmed]
  18. Tobramycin and ticarcillin therapy for exacerbations of pulmonary disease in patients with cystic fibrosis. Parry, M.F., Neu, H.C. J. Infect. Dis. (1976) [Pubmed]
  19. Simulation of human serum pharmacokinetics of ticarcillin-clavulanic acid and ceftazidime in rabbits, and efficacy against experimental Klebsiella pneumoniae meningitis. Mizen, L., Woodnutt, G., Kernutt, I., Catherall, E.J. Antimicrob. Agents Chemother. (1989) [Pubmed]
  20. Pharmacokinetics of ticarcillin and clavulanic acid (timentin) in relation to renal function. Jungbluth, G.L., Cooper, D.L., Doyle, G.D., Chudzik, G.M., Jusko, W.J. Antimicrob. Agents Chemother. (1986) [Pubmed]
  21. In vitro activity and in vivo evaluation of ticarcillin plus clavulanic acid against aerobic and anaerobic bacteria. Bansal, M.B., Chuah, S.K., Thadepalli, H. Am. J. Med. (1985) [Pubmed]
  22. In vivo inactivation of gentamicin by carbenicillin and ticarcillin. Kradjan, W.A., Burger, R. Arch. Intern. Med. (1980) [Pubmed]
  23. Timentin therapy for bone, joint, and deep soft tissue infections in children. Jacobs, R.F., Augustine, R.A., Aronson, J., McCarthy, R.E., Steele, R.W., Yamauchi, T. Am. J. Med. (1985) [Pubmed]
  24. Ticarcillin disodium in anaerobic infections. Webb, D., Thadepalli, H., Roy, I., Bach, V.T. Arch. Intern. Med. (1978) [Pubmed]
  25. Attenuation of experimental tobramycin nephrotoxicity by ticarcillin. English, J., Gilbert, D.N., Kohlhepp, S., Kohnen, P.W., Mayor, G., Houghton, D.C., Bennett, W.M. Antimicrob. Agents Chemother. (1985) [Pubmed]
  26. In vitro antibacterial activities of ticarcillin alone and ticarcillin plus clavulanic acid against beta-lactamase producing and non-producing microorganisms. Hsueh, P.R., Chang, S.C., Chen, Y.C., Hsu, L.Y., Luh, K.T., Hsieh, W.C. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi (1992) [Pubmed]
  27. In vitro activity of ticarcillin plus clavulanic acid against 632 clinical isolates. Fuchs, P.C., Barry, A.L., Thornsberry, C., Jones, R.N. Antimicrob. Agents Chemother. (1984) [Pubmed]
  28. Clinical trial of the efficacy and safety of ticarcillin and clavulanic acid. Roselle, G.A., Bode, R., Hamilton, B., Bibler, M., Sullivan, R., Douce, R., Staneck, J.L., Bullock, W.E. Antimicrob. Agents Chemother. (1985) [Pubmed]
  29. Molecular characterization of a novel class 1 integron containing bla(GES-1) and a fused product of aac3-Ib/aac6'-Ib' gene cassettes in Pseudomonas aeruginosa. Dubois, V., Poirel, L., Marie, C., Arpin, C., Nordmann, P., Quentin, C. Antimicrob. Agents Chemother. (2002) [Pubmed]
  30. Determination of ticarcillin levels in serum by high-pressure liquid chromatography. Shull, V.H., Dick, J.D. Antimicrob. Agents Chemother. (1985) [Pubmed]
  31. Long-term ticarcillin desensitization by the continuous oral administration of penicillin. Brown, L.A., Goldberg, N.D., Shearer, W.T. J. Allergy Clin. Immunol. (1982) [Pubmed]
  32. Ticarcillin concentrations in serum, muscle, and fat after a single intravenous injection. Daschner, F.D., Thoma, G., Langmaack, H., Dalhoff, A. Antimicrob. Agents Chemother. (1980) [Pubmed]
  33. Pharmacokinetics of ticarcillin in patients with abnormal renal function. Parry, M.F., Neu, H.C. J. Infect. Dis. (1976) [Pubmed]
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