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Chemical Compound Review:

Dithranol 1,8-dihydroxy-10H-anthracen- 9-one

Synonyms: Batridol, anthralin, Anthraline, Cigthranol, Dithranolum, ...

Fuchs, J. et al., Ferlan, A. et al., Schröder, J.M.

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Disease relevance of Dithranol

Bioenergetic parameters and redox properties of energy transducing membranes in rat liver mitochondria and cyanobacteria were investigated in the presence of the antipsoriatic compound anthralin (1,8-dihydroxy-9-anthrone) [1].
Dithranol (1,8-dihydroxy-9-anthrone), an efficient drug for the topical treatment of psoriasis undergoes a complex chemical transformation after topical application [2].

High impact information on Dithranol

Anthralin (1,8-dihydroxyanthrone) is a potent inhibitor of leukotriene production and LTB4-omega oxidation by human neutrophils [3].

References

The antipsoriatic compound anthralin influences bioenergetic parameters and redox properties of energy transducing membranes. Fuchs, J., Nitschmann, W.H., Packer, L. J. Invest. Dermatol. (1990) [Pubmed]
Dithranol reaction with nitroxide radicals in DMSO, a HPLC study. Ferlan, A., Pecar, S., Schara, M. Die Pharmazie. (2003) [Pubmed]
Anthralin (1,8-dihydroxyanthrone) is a potent inhibitor of leukotriene production and LTB4-omega oxidation by human neutrophils. Schröder, J.M. J. Invest. Dermatol. (1986) [Pubmed]

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