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Chemical Compound Review:

AG-G-29569 3-carboxypropyl-trimethyl- azanium chloride

Synonyms: AC1Q1RUO, LS-17139, CTK5B5181, KB-235420, AKOS015917353, ...

This record was replaced with 134.

Zaspel, B.J. et al., Gross, C.J. et al., Thoma, W.J. et al.

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High impact information on C01181

Carnitine transport by guinea-pig enterocytes demonstrate characteristics of a carrier-mediated process since it was inhibited by D-carnitine and trimethylaminobutyrate, as well as being temperature and concentration dependent [1].
Effect of vitamin C deficiency on hydroxylation of trimethylaminobutyrate to carnitine in the guinea pig [2].
During 30 min of recirculating perfusion, the small intestine absorbed trimethyllysine, hydroxytrimethyllysine, and trimethylaminobutyrate fairly well when they were administered via the lumen or the perfusate [3].
In both the isolated organ and in the whole animal, the kidney absorbs and metabolizes trimethyllysine more readily than the liver; whereas the liver absorbs trimethylaminobutyrate more rapidly than either the kidney or the small intestine and, unlike these organs, converts it to carnitine [3].

Associations of C01181 with other chemical compounds

Trimethyllysine and hydroxytrimethyllysine were taken up slowly by the kiodney and partially converted to trimethylaminobutyrate during 3409 min of perfusion [3].

References

Uptake of L-carnitine, D-carnitine and acetyl-L-carnitine by isolated guinea-pig enterocytes. Gross, C.J., Henderson, L.M., Savaiano, D.A. Biochim. Biophys. Acta (1986) [Pubmed]
Effect of vitamin C deficiency on hydroxylation of trimethylaminobutyrate to carnitine in the guinea pig. Thoma, W.J., Henderson, L.M. Biochim. Biophys. Acta (1984) [Pubmed]
Transport and metabolism of carnitine precursors in various organs of the rat. Zaspel, B.J., Sheridan, K.J., Henderson, L.M. Biochim. Biophys. Acta (1980) [Pubmed]

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