Disease relevance of Butedrine

• Among 18 drugs, a preparation of bamethan [1-(4-hydroxyphenyl)-1-hydroxy-2-butylaminoethane] showed strikingly high mutagenicity by this treatment toward Salmonella typhimurium TA98 and TA100 strains [1].

High impact information on Butedrine

• The retention times of atenolol and internal standard, bamethan, are 4.4 and 6.3 min, respectively [2].
• The effect on graft blood flow of two vasodilatory drugs, papaverine and bamethane (Vasculat), was infestigated by electromagnetic flowmetry intra-operatively in 31 patients following vascular reconstruction with a femoro-popliteal reversed saphenous vein bypass graft [3].
• Furthermore, 40 mg of papaverine and 100 mg of bamethane respectively induced a significantly larger increase in graft blood flow when injected into the popliteal artery than into the common femoral artery (p less than 0.01) [3].
• The leg blood flows were measured before and during local vasodilatation induced by intra-arterial injection of bamethane (Vasculat) [4].

References