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Chemical Compound Review

PAPAVERINE HYDROCHLORIDE     1-[(3,4- dimethoxyphenyl)methyl]- 6,7...

Synonyms: Dispamil, Drapavel, Forpavin, Pavatest, Therapav, ...
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Psychiatry related information on PAPAVERINE HYDROCHLORIDE

  • A double-blind, placebo-controlled study was conducted in 20 elderly patients with dementia associated with diffuse cerebrovascular disease to determine the effects of papaverine on the electrical activity of the brain [6].
  • The results suggest that measurement of corporal clearance of Tc-RBC after intracorporal injection of papaverine may be a useful method in detecting venous leak, and could be used as a screening test in patients with erectile dysfunction [7].
  • In Experiment I, the phosphodiesterase inhibitor papaverine (50 mg/kg), immediately after a one-trial acquisition task, functionally increased cAMP levels and prevented amnesia 3 h after treatment with AMPT (200 mg/kg) for New Zealand A strain (NZ/A) mice tested in a step-through passive avoidance apparatus [8].
  • Papaverine is found to inhibit conditioned avoidance responding in rats and mice and to inhibit PCP- and amphetamine-stimulated locomotor activity in rats [9].
  • Patients with a history of alcohol abuse or liver disease, however, should be followed up more closely when papaverine is selected for intracavernous injection [10].

High impact information on PAPAVERINE HYDROCHLORIDE


Chemical compound and disease context of PAPAVERINE HYDROCHLORIDE






Associations of PAPAVERINE HYDROCHLORIDE with other chemical compounds




Analytical, diagnostic and therapeutic context of PAPAVERINE HYDROCHLORIDE

  • CR (papaverine/resting perfusion) was 3.8 +/- 0.2 and 1.51 +/- 0.27 in normal subjects and in ischemic patients, respectively (p < 0.01) [26].
  • This effect was paralleled by an almost 4-fold increase in forearm blood flow (FBF), whereas an equieffective dose of papaverine produced no change in venous NO(2)-. Intraarterial infusion of NO(2)- had no effect on FBF [36].
  • Both increased after angioplasty to 3.65 +/- 0.57 and 3.36 +/- 0.70, respectively (P < .05) [37].
  • The coronary blood flow velocity at rest and in response to a hyperemic dose of papaverine was measured [38].
  • Maximal vasodilation was induced immediately before and 15 minutes after PTCA by intracoronary administration of papaverine, and digital angiographic studies were performed [39].


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  4. A rationale for the treatment of metastatic neuroblastoma. Helson, L., Helson, C., Peterson, R.F., Das, S.K. J. Natl. Cancer Inst. (1976) [Pubmed]
  5. Comparison of an intravenous selective mesenteric vasodilator with intraarterial papaverine in experimental nonocclusive mesenteric ischemia. MacCannell, K.L. Gastroenterology (1986) [Pubmed]
  6. Effect of papaverine on cerebral electrogenesis. Culebras, A. Neurology (1976) [Pubmed]
  7. Radionuclide assessment of penile corporal venous leak using technetium-99m-labeled red blood cells. Groshar, D., Lidgi, S., Frenkel, A., Vardi, Y. J. Nucl. Med. (1992) [Pubmed]
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  9. Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis. Siuciak, J.A., Chapin, D.S., Harms, J.F., Lebel, L.A., McCarthy, S.A., Chambers, L., Shrikhande, A., Wong, S., Menniti, F.S., Schmidt, C.J. Neuropharmacology (2006) [Pubmed]
  10. Hepatotoxicity related to intracavernous pharmacotherapy with papaverine. Brown, S.L., Haas, C.A., Koehler, M., Bodner, D.R., Seftel, A.D. Urology (1998) [Pubmed]
  11. A study of protein phosphorylation in shape change and Ca++-dependent serotonin release by blood platelets. Bennett, W.F., Belville, J.S., Lynch, G. Cell (1979) [Pubmed]
  12. Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells. Ishii, D.N., Fibach, E., Yamasaki, H., Weinstein, I.B. Science (1978) [Pubmed]
  13. Synaptic potentials in sympathetic ganglia: are they mediated by cyclic nucleotides? Busis, N.A., Weight, F.F., Smith, P.A. Science (1978) [Pubmed]
  14. Hemodynamic sequelae of regression of experimental atherosclerosis. Armstrong, M.L., Heistad, D.D., Marcus, M.L., Piegors, D.J., Abboud, F.M. J. Clin. Invest. (1983) [Pubmed]
  15. Resolution of lower limb neurological deficit with penile papaverine in spinal arteriovenous malformation. Rakhit, R.D., Beck, R., Foster, O., Thompson, A.J., Kendall, B. Lancet (1993) [Pubmed]
  16. Large vessel impedance in peripheral atherosclerosis. Farrar, D.J., Malindzak, G.S., Johnson, G. Circulation (1977) [Pubmed]
  17. Effects of adenosine on human coronary arterial circulation. Wilson, R.F., Wyche, K., Christensen, B.V., Zimmer, S., Laxson, D.D. Circulation (1990) [Pubmed]
  18. Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation? Folts, J.D., Gallagher, K., Rowe, G.G. Circulation (1982) [Pubmed]
  19. Intracoronary papaverine: an ideal coronary vasodilator for studies of the coronary circulation in conscious humans. Wilson, R.F., White, C.W. Circulation (1986) [Pubmed]
  20. Vascular free radical release. Ex vivo and in vivo evidence for a flow-dependent endothelial mechanism. Laurindo, F.R., Pedro, M.d.e. .A., Barbeiro, H.V., Pileggi, F., Carvalho, M.H., Augusto, O., da Luz, P.L. Circ. Res. (1994) [Pubmed]
  21. Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection. Hurt, K.J., Musicki, B., Palese, M.A., Crone, J.K., Becker, R.E., Moriarity, J.L., Snyder, S.H., Burnett, A.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  22. Direct vasoconstriction and endothelium-dependent vasodilation. Mechanisms of acetylcholine effects on coronary flow and arterial diameter in patients with nonstenotic coronary arteries. Hodgson, J.M., Marshall, J.J. Circulation (1989) [Pubmed]
  23. Immunological identification of the major platelet low-Km cAMP phosphodiesterase: probable target for anti-thrombotic agents. Macphee, C.H., Harrison, S.A., Beavo, J.A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  24. Influence of papaverine on bethanechol or OP-CCK stimulation of feline colonic muscle. Snape, W.J. Gastroenterology (1981) [Pubmed]
  25. Differential structural responses of small resistance vessels to antihypertensive therapy. Sano, T., Tarazi, R.C. Circulation (1987) [Pubmed]
  26. Residual coronary reserve despite decreased resting blood flow in patients with critical coronary lesions. A study by technetium-99m human albumin microsphere myocardial scintigraphy. Parodi, O., Sambuceti, G., Roghi, A., Testa, R., Inglese, E., Pirelli, S., Spinelli, F., Campolo, L., L'Abbate, A. Circulation (1993) [Pubmed]
  27. Sympathetic stimulation overrides flow-mediated endothelium-dependent epicardial coronary vasodilation in transplant patients. Aptecar, E., Dupouy, P., Benvenuti, C., Mazzucotelli, J.P., Teiger, E., Geschwind, H., Castaigne, A., Loisance, D., Dubois-Rande, J.L. Circulation (1996) [Pubmed]
  28. Coronary vasodilator reserve. Comparison of the effects of papaverine and adenosine on coronary flow, ventricular function, and myocardial metabolism. Christensen, C.W., Rosen, L.B., Gal, R.A., Haseeb, M., Lassar, T.A., Port, S.C. Circulation (1991) [Pubmed]
  29. Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia. Zeiher, A.M., Krause, T., Schächinger, V., Minners, J., Moser, E. Circulation (1995) [Pubmed]
  30. Coronary dilation with standard dose dipyridamole and dipyridamole combined with handgrip. Rossen, J.D., Simonetti, I., Marcus, M.L., Winniford, M.D. Circulation (1989) [Pubmed]
  31. Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia? Iadecola, C. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  32. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. Nibuya, M., Nestler, E.J., Duman, R.S. J. Neurosci. (1996) [Pubmed]
  33. Identification, localization and functional in vitro and in vivo activity of oxytocin receptor in the rat penis. Zhang, X.H., Filippi, S., Vignozzi, L., Morelli, A., Mancina, R., Luconi, M., Donati, S., Marini, M., Vannelli, G.B., Forti, G., Maggi, M. J. Endocrinol. (2005) [Pubmed]
  34. Endothelin-1 affects capsaicin-evoked release of neuropeptides from rat vas deferens. Filippelli, A., Falciani, M., Piucci, B., D'Amico, M., D'Agostino, B., Filippelli, W., Rossi, F. Eur. J. Pharmacol. (1999) [Pubmed]
  35. IL-10 deficiency increases superoxide and endothelial dysfunction during inflammation. Gunnett, C.A., Heistad, D.D., Berg, D.J., Faraci, F.M. Am. J. Physiol. Heart Circ. Physiol. (2000) [Pubmed]
  36. Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action. Lauer, T., Preik, M., Rassaf, T., Strauer, B.E., Deussen, A., Feelisch, M., Kelm, M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  37. Improvement of subendocardial myocardial perfusion after percutaneous transluminal coronary angioplasty. A myocardial contrast echocardiography study with correlation between myocardial contrast reserve and Doppler coronary reserve. Perchet, H., Dupouy, P., Duval-Moulin, A.M., Hittinger, L., Pelle, G., Brun, P., Castaigne, A., Geschwind, H., Dubois-Randé, J.L. Circulation (1995) [Pubmed]
  38. Is coronary flow reserve in response to papaverine really normal in syndrome X? Chauhan, A., Mullins, P.A., Petch, M.C., Schofield, P.M. Circulation (1994) [Pubmed]
  39. Concept of maximal flow ratio for immediate evaluation of percutaneous transluminal coronary angioplasty result by videodensitometry. Pijls, N.H., Aengevaeren, W.R., Uijen, G.J., Hoevelaken, A., Pijnenburg, T., van Leeuwen, K., van der Werf, T. Circulation (1991) [Pubmed]
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