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Chemical Compound Review

ROSE BENGAL     2,3,4,5-tetrachloro-6-(6- hydroxy-2,4,5,7...

Synonyms: CHEBI:782373, NSC10463, NSC45732, Acid Red 94, NSC270091, ...
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Disease relevance of ROSE BENGAL

  • MATERIALS AND METHODS: Stationary-phase cells of Deinococcus radiodurans (Gram-positive) and Escherichia coli (Gram-negative) were exposed to visible light in a buffer solution containing up to 5 microg/ml sensitizer rose bengal (RB) and to X-rays at dose rates of 32.8 Gy/min or 14.6 Gy/min, respectively [1].
  • Under conditions of RB treatment, where hemolysis was absent or minimal, 125I anti-D IgG binding decreased to 38-49% of the level seen in controls [2].

High impact information on ROSE BENGAL

  • Collectively, a model for the PDT-triggered apoptotic signalling cascade with RB is proposed, which involves singlet oxygen, JNK, caspase-3 and PAK2, sequentially [3].
  • Our previous work showed that absorption of visible light by rose bengal (RB) produces singlet oxygen exclusively, whereas absorption of ultraviolet A produces RB-derived radicals in addition to singlet oxygen [4].
  • Singlet oxygen, but not the RB-derived radicals, induced nuclear condensation and DNA fragmentation into nucleosome-size fragments in a dose dependent manner [4].
  • RESULTS: Survival of both cell types decreased with increasing exposure time to visible light and increasing concentration of RB, and therefore with an increase in singlet oxygen production [1].


  1. High sensitivity of Deinococcus radiodurans to photodynamically-produced singlet oxygen. Schäfer, M., Schmitz, C., Horneck, G. Int. J. Radiat. Biol. (1998) [Pubmed]
  2. Rh antigen immunoreactivity after histidine modification. Victoria, E.J., Branks, M.J., Masouredis, S.P. Mol. Immunol. (1986) [Pubmed]
  3. Apoptotic signalling cascade in photosensitized human epidermal carcinoma A431 cells: involvement of singlet oxygen, c-Jun N-terminal kinase, caspase-3 and p21-activated kinase 2. Chan, W.H., Yu, J.S., Yang, S.D. Biochem. J. (2000) [Pubmed]
  4. Singlet oxygen, but not oxidizing radicals, induces apoptosis in HL-60 cells. Kochevar, I.E., Lynch, M.C., Zhuang, S., Lambert, C.R. Photochem. Photobiol. (2000) [Pubmed]
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