Gene Review:
PAK2 - p21 protein (Cdc42/Rac)-activated kinase 2
Homo sapiens
Synonyms:
Gamma-PAK, PAK-2, PAK65, PAKgamma, S6/H4 kinase, ...
- "UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infection. Nguyen, D.G., Wolff, K.C., Yin, H., Caldwell, J.S., Kuhen, K.L. J. Virol. (2006)
- Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice. Vincent, P., Priceputu, E., Kay, D., Saksela, K., Jolicoeur, P., Hanna, Z. J. Biol. Chem. (2006)
- Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK. Misra, U.K., Deedwania, R., Pizzo, S.V. J. Biol. Chem. (2005)
- Lentivirus Nef specifically activates Pak2. Arora, V.K., Molina, R.P., Foster, J.L., Blakemore, J.L., Chernoff, J., Fredericksen, B.L., Garcia, J.V. J. Virol. (2000)
- Curcumin inhibits UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma A431 cells. Chan, W.H., Wu, C.C., Yu, J.S. J. Cell. Biochem. (2003)
- Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Rudel, T., Bokoch, G.M. Science (1997)
- The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells. Mikolajczak, S.A., Ma, B.Y., Yoshida, T., Yoshida, R., Kelvin, D.J., Ochi, A. J. Exp. Med. (2004)
- Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. Hirata, H., Takahashi, A., Kobayashi, S., Yonehara, S., Sawai, H., Okazaki, T., Yamamoto, K., Sasada, M. J. Exp. Med. (1998)
- Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation. Wei, B.L., Arora, V.K., Raney, A., Kuo, L.S., Xiao, G.H., O'Neill, E., Testa, J.R., Foster, J.L., Garcia, J.V. J. Virol. (2005)
- Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef. Giese, S.I., Woerz, I., Homann, S., Tibroni, N., Geyer, M., Fackler, O.T. Virology (2006)
- Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation. Renkema, G.H., Pulkkinen, K., Saksela, K. Mol. Cell. Biol. (2002)
- Identification of the regulatory autophosphorylation site of autophosphorylation-dependent protein kinase (auto-kinase). Evidence that auto-kinase belongs to a member of the p21-activated kinase family. Yu, J.S., Chen, W.J., Ni, M.H., Chan, W.H., Yang, S.D. Biochem. J. (1998)
- Heat shock stress induces cleavage and activation of PAK2 in apoptotic cells. Chan, W.H., Yu, J.S., Yang, S.D. J. Protein Chem. (1998)
- Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2. Hoelz, A., Janz, J.M., Lawrie, S.D., Corwin, B., Lee, A., Sakmar, T.P. J. Mol. Biol. (2006)
- p21-activated kinase (PAK) is required for Fas-induced JNK activation in Jurkat cells. Rudel, T., Zenke, F.T., Chuang, T.H., Bokoch, G.M. J. Immunol. (1998)
- Cytostatic p21 G protein-activated protein kinase gamma-PAK. Roig, J., Traugh, J.A. Vitam. Horm. (2001)
- Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth. Shin, E.Y., Shin, K.S., Lee, C.S., Woo, K.N., Quan, S.H., Soung, N.K., Kim, Y.G., Cha, C.I., Kim, S.R., Park, D., Bokoch, G.M., Kim, E.G. J. Biol. Chem. (2002)
- p21-activated protein kinase gamma-PAK is activated by ionizing radiation and other DNA-damaging agents. Similarities and differences to alpha-PAK. Roig, J., Traugh, J.A. J. Biol. Chem. (1999)
- Reconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex. Raney, A., Kuo, L.S., Baugh, L.L., Foster, J.L., Garcia, J.V. J. Virol. (2005)
- Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2. Goeckeler, Z.M., Masaracchia, R.A., Zeng, Q., Chew, T.L., Gallagher, P., Wysolmerski, R.B. J. Biol. Chem. (2000)
- Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression. Rong, R., Surace, E.I., Haipek, C.A., Gutmann, D.H., Ye, K. Oncogene (2004)
- Apoptotic signalling cascade in photosensitized human epidermal carcinoma A431 cells: involvement of singlet oxygen, c-Jun N-terminal kinase, caspase-3 and p21-activated kinase 2. Chan, W.H., Yu, J.S., Yang, S.D. Biochem. J. (2000)
- Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. Kärkkäinen, S., Hiipakka, M., Wang, J.H., Kleino, I., Vähä-Jaakkola, M., Renkema, G.H., Liss, M., Wagner, R., Saksela, K. EMBO Rep. (2006)
- Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity. Walter, B.N., Huang, Z., Jakobi, R., Tuazon, P.T., Alnemri, E.S., Litwack, G., Traugh, J.A. J. Biol. Chem. (1998)
- Proteolytic cleavage and activation of PAK2 during UV irradiation-induced apoptosis in A431 cells. Tang, T.K., Chang, W.C., Chan, W.H., Yang, S.D., Ni, M.H., Yu, J.S. J. Cell. Biochem. (1998)
- Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3. Wilkes, M.C., Murphy, S.J., Garamszegi, N., Leof, E.B. Mol. Cell. Biol. (2003)
- Inhibition of cap-dependent translation via phosphorylation of eIF4G by protein kinase Pak2. Ling, J., Morley, S.J., Traugh, J.A. EMBO J. (2005)
- Up-regulation of p21- and RhoA-activated protein kinases in human pregnant myometrium. Moore, F., Da Silva, C., Wilde, J.I., Smarason, A., Watson, S.P., López Bernal, A. Biochem. Biophys. Res. Commun. (2000)
- A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. Martin, G.A., Bollag, G., McCormick, F., Abo, A. EMBO J. (1995)
- A novel role for p21-activated protein kinase 2 in T cell activation. Chu, P.C., Wu, J., Liao, X.C., Pardo, J., Zhao, H., Li, C., Mendenhall, M.K., Pali, E., Shen, M., Yu, S., Taylor, V.C., Aversa, G., Molineaux, S., Payan, D.G., Masuda, E.S. J. Immunol. (2004)
- Evaluation of the catalytic mechanism of the p21-activated protein kinase PAK2. Wu, H., Zheng, Y., Wang, Z.X. Biochemistry (2003)
- Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening. Kurakin, A.V., Wu, S., Bredesen, D.E. J. Biol. Chem. (2003)
- Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis. Lee, N., MacDonald, H., Reinhard, C., Halenbeck, R., Roulston, A., Shi, T., Williams, L.T. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation. Gatti, A., Huang, Z., Tuazon, P.T., Traugh, J.A. J. Biol. Chem. (1999)
- Isolation and characterization of a structural homologue of human PRK2 from rat liver. Distinguishing substrate and lipid activator specificities. Yu, W., Liu, J., Morrice, N.A., Wettenhall, R.E. J. Biol. Chem. (1997)