The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Atussil     2-(2-diethylaminoethoxy)ethyl 1...

Synonyms: Pentoxiverin, Pentoxyverin, Pentoxiverina, Pentoxyverine, Pentoxiverinum, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Psychiatry related information on Pentoxyverine

  • The non-opioid antitussives dextromethorphan and carbetapentane, the active ingredients of several over-the-counter cough suppressants, provide a dose-related protection against maximal electroshock seizures in rats [1].

High impact information on Pentoxyverine

  • In this work, CE separation with end-column Ru(bpy)3(2+) ECL detection for the quantitative determination of pentoxyverine was firstly performed [2].
  • Identification of D3 and sigma receptors in the rat striatum and nucleus accumbens using (+/-)-7-hydroxy-N,N-di-n-[3H]propyl-2-aminotetralin and carbetapentane [3].
  • In transfected CCL1.3 mouse fibroblasts expressing the human D3 receptor, neither DTG nor carbetapentane (0.1 microM) displaced (+/-)-7-OH-[3H]DPAT binding [3].
  • Carbetapentane and R(-)-PPAP (0.1 microM) displaced approximately 20-50% of total (+/-)-7-OH-[3H]DPAT binding in striatum, nucleus accumbens, and olfactory tubercle in autoradiographic studies, with the nucleus accumbens shell subregion exhibiting the greatest displacement [3].
  • However, carbetapentane interacts at muscarinic binding sites as well, and it is not clear whether either of these receptor systems is involved in the mechanism(s) of action(s) of this drug [4].

Chemical compound and disease context of Pentoxyverine


Biological context of Pentoxyverine


Anatomical context of Pentoxyverine


Associations of Pentoxyverine with other chemical compounds


Gene context of Pentoxyverine


  1. Dextromethorphan and carbetapentane: centrally acting non-opioid antitussive agents with novel anticonvulsant properties. Tortella, F.C., Musacchio, J.M. Brain Res. (1986) [Pubmed]
  2. Study on the enhancement of Ru(bpy)3(2+) electrochemiluminescence by nanogold and its application for pentoxyverine detection. Liu, Y., Pan, W., Liu, Q., Yao, S. Electrophoresis (2005) [Pubmed]
  3. Identification of D3 and sigma receptors in the rat striatum and nucleus accumbens using (+/-)-7-hydroxy-N,N-di-n-[3H]propyl-2-aminotetralin and carbetapentane. Wallace, D.R., Booze, R.M. J. Neurochem. (1995) [Pubmed]
  4. Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands. Calderon, S.N., Izenwasser, S., Heller, B., Gutkind, J.S., Mattson, M.V., Su, T.P., Newman, A.H. J. Med. Chem. (1994) [Pubmed]
  5. Dextromethorphan binding sites in the guinea pig brain. Musacchio, J.M., Klein, M. Cell. Mol. Neurobiol. (1988) [Pubmed]
  6. Effects of sigma ligands on the cloned mu-, delta- and kappa-opioid receptors co-expressed with G-protein-activated K+ (GIRK) channel in Xenopus oocytes. Kobayashi, T., Ikeda, K., Ichikawa, T., Togashi, S., Kumanishi, T. Br. J. Pharmacol. (1996) [Pubmed]
  7. Evidence for sigma-1-like receptors in isolated rat liver mitochondrial membranes. Klouz, A., Sapena, R., Liu, J., Maurice, T., Tillement, J.P., Papadopoulos, V., Morin, D. Br. J. Pharmacol. (2002) [Pubmed]
  8. Allosteric modulation of dextromethorphan binding sites. Musacchio, J.M., Klein, M., Santiago, L.J. Neuropharmacology (1987) [Pubmed]
  9. Antitussive activity of sigma-1 receptor agonists in the guinea-pig. Brown, C., Fezoui, M., Selig, W.M., Schwartz, C.E., Ellis, J.L. Br. J. Pharmacol. (2004) [Pubmed]
  10. Non-opioid antitussives inhibit endogenous glutamate release from rabbit hippocampal slices. Annels, S.J., Ellis, Y., Davies, J.A. Brain Res. (1991) [Pubmed]
  11. Effects of non-opioid antitussives on hypoxia-induced electrical changes in rat hippocampal slices: a comparative study with anticonvulsant drugs. Domenici, M.R., Sagratella, S., Frank, C., Scotti de Carolis, A. Gen. Pharmacol. (1993) [Pubmed]
WikiGenes - Universities