Disease relevance of Monomethylthiourea

• Before N-methylthiourea would produce toxicity, it would be further biotransformed to its S-oxidized metabolites mainly by FMO [1].

High impact information on Monomethylthiourea

• These structural requirements and the known toxicity of thiono-sulfur compounds led us to the hypothesis that MMI would undergo epoxidation of the C-4,5 double bond by P450 enzymes and, after being hydrolyzed, the resulting epoxide would be then decomposed to form N-methylthiourea, a proximate toxicant [1].
• 3. At least 50% of an i.p. dose (100 mg/kg) of MHT is excreted unchanged and some of this undergoes hydrolysis within the urine to N-methylthiourea and formaldehyde [2].
• Identification of 1-methylthiourea as the metabolite of ethylenethiourea in rats by high-performance liquid chromatography [3].
• 3. Six solvent-extractable metabolites were isolated and characterized by t.l.c. and high-resolution mass spectrometry, as N-methylimidazole, S-methylmethimazole, 3-methyl-2-thiohydantoin, 1-methyl-2-thiohydantoic acid, N-methylthiourea and a methylhydantoin [4].
• Administration of 1-methylthiourea and 1-ethylthiourea, however, resulted in high incidences of malformations in the rat but not in the mouse fetuses [5].

Analytical, diagnostic and therapeutic context of Monomethylthiourea

• About 0.014 ppm of 1-methylthiourea was detected as the metabolite of ETU in plasma collected 2 h after an oral administration of 200 mg/kg of ETU [3].

References